干燥综合征(Sjögren's syndrome, SS)是一种慢性自身免疫性结缔组织疾病,主要由遗传、内分泌、病毒感染等多种因素引发,导致唾液腺、泪腺等外分泌腺功能受损,临床表现为口干、眼干、皮肤干燥、关节疼痛、消化系统及呼吸系统等多系统受累症状。干燥综合征可以分为原发性和继发性两种类型。原发性干燥综合征(pSS)是指不伴有其他自身免疫性疾病的情况,而继发性干燥综合征则是与其他自身免疫性疾病如类风湿关节炎或系统性红斑狼疮等并发的情况。
干燥综合征的药物研发主要集中在以下几个方向:
- B细胞靶向疗法:由于干燥综合征是一种表现为B细胞高度活跃的疾病,B细胞亚群的异常在疾病的发生发展中可能扮演关键的角色,因此靶向B细胞的治疗策略备受关注。目前研究的主要药物包括靶向B细胞表面CD20的利妥昔单抗、靶向BAFF-R的单抗药物Ianalumab,以及我国自主研发的1.1类新药艾拉莫德(IGU),这些药物均针对B细胞的存活或功能进行抑制。
- FcRn单抗疗法:Nipocalimab是一种抗新生儿Fc受体(FcRn)的单克隆抗体,通过选择性阻断IgG与FcRn的相互作用以降低包括自身抗体在内的循环IgG水平,从而改善干燥综合征患者的病情。这一疗法的有效性已在临床II期研究中得到验证。
- CD40L拮抗剂:Dazodalibep是一种非抗体融合蛋白,可作为CD40L拮抗剂,阻断T细胞、B细胞和抗原呈递细胞之间的协同刺激信号,从而降低与B细胞、T细胞和树突状细胞生物标志物相关的多种蛋白质在干燥综合征患者中的水平。
- TYK2抑制剂:氘可来昔替尼(BMS-986165)是一种高效选择性的TYK2变构抑制剂,可靶向作用于干燥综合征相关细胞因子(包括I型IFN、白介素-12和白介素-23),通过阻断这些通路的信号传导来发挥作用,该药物已在2023年批准上市。
其他如CD19、CD22、IL2R、IL17R等也是干燥综合征药物研发的重要靶点。针对这些靶点的药物也在临床研发中,并显示出一定的疗效。
华美生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,特整理了一系列与干燥综合征研究相关的热门靶点及相关试剂产品列举如下,供您选择:
干燥综合征在研药物靶点
干燥综合征药物靶点相关产品推荐
● 靶点蛋白
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP004936HU1

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
CSB-MP004937HU3

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.
CSB-MP010958HU1

Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP853495HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 2 μg/ml can bind TNFRSF13C, the EC50 is 9.943-15.72 ng/ml
CSB-MP897523HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Target | Product Name | Source | Tag Info | Product Code |
---|---|---|---|---|
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP004900HU1 |
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial (Active) | Mammalian cell | C-terminal 6xHis-tagged | CSB-MP004900HU |
CD22 | Recombinant Human B-cell receptor CD22 (CD22), partial, Biotinylated | Mammalian cell | C-terminal 6xHis-Avi-tagged | CSB-MP004900HU-B |
CD28 | Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial | Mammalian cell | C-terminal hFc-tagged | CSB-MP004913HU1 |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005181HU |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP004936HU1 |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | E.coli | C-terminal 6xHis-tagged | CSB-EP851448PI |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal hFc-tagged | CSB-YP851448PI |
CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal 6xHis-tagged | CSB-YP851448PIc7 |
CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Baculovirus | C-terminal hFc-Avi-tagged | CSB-BP004936HU1 |
CD40LG | Recombinant Macaca mulatta CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937MOW |
CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937RB |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | E.coli | N-terminal GST-tagged | CSB-RP060054h |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937HU1 |
CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937RB |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial (Active) | E.coli | Tag-Free | CSB-AP005191HU |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial (Active) | Mammalian cell | N-terminal hFc-Flag-tagged | CSB-MP004937HU3 |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated | Mammalian cell | N-terminal hFc-Avi-tagged | CSB-MP004937HU3-B |
CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937HU1a0 |
FCGRT | Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial | E.coli | N-terminal GST-tagged | CSB-EP008545HU |
● 抗体
CSB-RA962691A0HU

Tested Applications:
ELISA, IHC
CSB-RA004936MA1HU

Tested Applications:
ELISA, IF, FC
CSB-RA015007MA4HU

Tested Applications:
ELISA, IHC, IF
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC
- 重组抗体
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
CD22 | CD22 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA962691A0HU |
CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
IFNAR1 | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA011046A0HU |
IL23A | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA251959A0HU |
MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
PDCD1 | PDCD1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA240597A0HU |
- 单克隆抗体
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
MS4A1 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000204 |
MS4A1 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA996413 |
- 多克隆抗体
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA004900ESR1HU |
CD22 | CD22 Antibody | Human | ELISA, WB | CSB-PA070294 |
CD22 | Phospho-CD22 (Y807) Antibody | Human | ELISA, WB, IHC | CSB-PA070293 |
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA616669 |
CD22 | CD22 Antibody | Human | ELISA, IHC | CSB-PA576542 |
CD22 | CD22 Antibody | Human | ELISA, WB | CSB-PA828492 |
CD22 | CD22 (Ab-807) Antibody | Human | ELISA, WB | CSB-PA953915 |
CD22 | Phospho-CD22 (Tyr807) Antibody | Human | ELISA, WB | CSB-PA912726 |
CD28 | CD28 Antibody | Human | ELISA, WB | CSB-PA005199 |
CD28 | Phospho-CD28 (Y218) Antibody | Human, Mouse | ELISA, WB | CSB-PA070302 |
CD40 | CD40 Antibody | Human, Mouse | ELISA, WB, IF | CSB-PA004936LA01HU |
CD40 | CD40 Antibody | Human, Mouse, Monkey | ELISA, WB, IHC | CSB-PA001455 |
CD40 | Phospho-CD40 (T254) Antibody | Human, Mouse | ELISA, WB | CSB-PA080031 |
CD40 | CD40 Antibody | Human | ELISA, WB | CSB-PA004936GA01HU |
CD40 | CD40 Antibody | Human, Mouse | ELISA, IHC | CSB-PA215588 |
CD40 | Phospho-CD40 (Thr254) Antibody | Human, Mouse | ELISA, WB | CSB-PA176134 |
CD40LG | CD40LG Antibody | Human | ELISA | CSB-PA06005A0Rb |
CD40LG | CD40LG Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA004937GA01HU |
CD40LG | CD40LG Antibody | Human, Mouse | ELISA, WB | CSB-PA067336 |
FCGRT | FCGRT Antibody | Human, Mouse | ELISA, WB, IHC, IF | CSB-PA008545EA01HU |
● ELISA试剂盒
Target | Product Name | Sample Types | Detection Range | Code |
---|---|---|---|---|
CD40LG | Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E04716h |
CD40 | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | Request Information | CSB-EL004936MO | |
CD40LG | Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates. | 0.274 ng/ml-200 ng/ml. | CSB-E04717m |
CD40LG | Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 1.87 ng/mL-120 ng/mL | CSB-E07395r |
CD28 | Human soluble cluster of differentiation 28,sCD28 ELISA Kit | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-E09296h |
TNFSF13B | Human B cell activation factor,BAFF ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E11912h |
PDCD1 | Mouse Programmed Death 1(PD-1)ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.312 ng/mL-20 ng/mL | CSB-E13586m |
PDCD1 | Human Programmed Death 1(PD-1)ELISA KIT | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E13643h |
MS4A1 | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 3.12 ng/mL-200 ng/mL | CSB-E14007h |
IL12A | Bovine Interleukin 12,IL-12 ELISA Kit | serum, plasma, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E14010B |
IL7R | Human Soluble Interleukin-7 Receptor,sIL-7R ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL-50 ng/mL | CSB-E14020h |
IL23A | Human Interleukin-23 subunit alpha(IL-23A) Elisa kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 62.5 pg/mL-4000 pg/mL | CSB-E17339h |
FCGRT | Human IgG receptor FcRn large subunit p51(FCGRT) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-EL008545HU |
ICOSLG | Human ICOS ligand(ICOSLG) ELISA kit | serum, plasma, tissue homogenates | 93.75 pg/mL-6000 pg/mL | CSB-EL010958HU |
ICOSLG | Mouse ICOS ligand(ICOSLG) ELISA kit | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL | CSB-EL010958MO |
IFNA2 | Human interferon alpha-2(IFNA2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-EL011038HU |
IFNA2 | Mouse interferon alpha-2(IFNA2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 9.38 pg/mL-600 pg/mL | CSB-EL011038MO |
IL23A | Pig Interleukin-23 subunit alpha(IL23A) ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-EL011638PI |
IL7R | Mouse Interleukin-7 receptor subunit alpha(IL7R) ELISA kit | serum, plasma, tissue homogenates | 78 pg/ml - 5000 pg/ml | CSB-EL011670MO |
TNFRSF13C | Mouse Tumor necrosis factor receptor superfamily member 13C(TNFRSF13C) ELISA kit | serum, plasma, tissue homogenates | 39 pg/ml - 2500 pg/ml | CSB-EL023972MO |