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自身免疫疾病系列——

干燥综合征

干燥综合征

干燥综合征(Sjögren's syndrome, SS)是一种慢性自身免疫性结缔组织疾病,主要由遗传、内分泌、病毒感染等多种因素引发,导致唾液腺、泪腺等外分泌腺功能受损,临床表现为口干、眼干、皮肤干燥、关节疼痛、消化系统及呼吸系统等多系统受累症状。干燥综合征可以分为原发性和继发性两种类型。原发性干燥综合征(pSS)是指不伴有其他自身免疫性疾病的情况,而继发性干燥综合征则是与其他自身免疫性疾病如类风湿关节炎或系统性红斑狼疮等并发的情况。

干燥综合征的药物研发主要集中在以下几个方向:

  • B细胞靶向疗法:由于干燥综合征是一种表现为B细胞高度活跃的疾病,B细胞亚群的异常在疾病的发生发展中可能扮演关键的角色,因此靶向B细胞的治疗策略备受关注。目前研究的主要药物包括靶向B细胞表面CD20的利妥昔单抗、靶向BAFF-R的单抗药物Ianalumab,以及我国自主研发的1.1类新药艾拉莫德(IGU),这些药物均针对B细胞的存活或功能进行抑制。
  • FcRn单抗疗法:Nipocalimab是一种抗新生儿Fc受体(FcRn)的单克隆抗体,通过选择性阻断IgG与FcRn的相互作用以降低包括自身抗体在内的循环IgG水平,从而改善干燥综合征患者的病情。这一疗法的有效性已在临床II期研究中得到验证。
  • CD40L拮抗剂:Dazodalibep是一种非抗体融合蛋白,可作为CD40L拮抗剂,阻断T细胞、B细胞和抗原呈递细胞之间的协同刺激信号,从而降低与B细胞、T细胞和树突状细胞生物标志物相关的多种蛋白质在干燥综合征患者中的水平。
  • TYK2抑制剂:氘可来昔替尼(BMS-986165)是一种高效选择性的TYK2变构抑制剂,可靶向作用于干燥综合征相关细胞因子(包括I型IFN、白介素-12和白介素-23),通过阻断这些通路的信号传导来发挥作用,该药物已在2023年批准上市。

其他如CD19、CD22、IL2R、IL17R等也是干燥综合征药物研发的重要靶点。针对这些靶点的药物也在临床研发中,并显示出一定的疗效。

华美生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,特整理了一系列与干燥综合征研究相关的热门靶点及相关试剂产品列举如下,供您选择:

干燥综合征药物靶点相关产品推荐

● 靶点蛋白

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP004936HU1 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CSB-MP004937HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.

CSB-MP010958HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml

MS4A1(CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP853495HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 2 μg/ml can bind TNFRSF13C, the EC50 is 9.943-15.72 ng/ml

CSB-MP897523HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

Target Product Name Source Tag Info Product Code
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial E.coli N-terminal 6xHis-SUMO-tagged CSB-EP004900HU1
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial (Active) Mammalian cell C-terminal 6xHis-tagged CSB-MP004900HU
CD22 Recombinant Human B-cell receptor CD22 (CD22), partial, Biotinylated Mammalian cell C-terminal 6xHis-Avi-tagged CSB-MP004900HU-B
CD28 Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial Mammalian cell C-terminal hFc-tagged CSB-MP004913HU1
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal Fc-tagged CSB-AP005181HU
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal hFc-tagged CSB-MP004936HU1
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial E.coli C-terminal 6xHis-tagged CSB-EP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal hFc-tagged CSB-YP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal 6xHis-tagged CSB-YP851448PIc7
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial Baculovirus C-terminal hFc-Avi-tagged CSB-BP004936HU1
CD40LG Recombinant Macaca mulatta CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937MOW
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial E.coli N-terminal GST-tagged CSB-RP060054h
CD40LG Recombinant Human CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937HU1
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial (Active) E.coli Tag-Free CSB-AP005191HU
CD40LG Recombinant Human CD40 ligand (CD40LG), partial (Active) Mammalian cell N-terminal hFc-Flag-tagged CSB-MP004937HU3
CD40LG Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated Mammalian cell N-terminal hFc-Avi-tagged CSB-MP004937HU3-B
CD40LG Recombinant Human CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937HU1a0
FCGRT Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial E.coli N-terminal GST-tagged CSB-EP008545HU

● 抗体

CD22 Recombinant Monoclonal Antibody
CSB-RA962691A0HU
CSB-RA962691A0HU IHC

Tested Applications:
ELISA, IHC

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Tested Applications:
ELISA, IF, FC

MS4A1 Recombinant Monoclonal Antibody
CSB-RA015007MA4HU
CSB-RA015007MA4HU IF

Tested Applications:
ELISA, IHC, IF

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU
CSB-RA240597A0HU WB

Tested Applications:
ELISA, WB, IHC

- 重组抗体

Target Product Name Species Reactivity Tested Applications Code
CD22 CD22 Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA962691A0HU
CD40 CD40 Recombinant Monoclonal Antibody Human ELISA, IF, FC CSB-RA004936MA1HU
IFNAR1 IFNAR1 Recombinant Monoclonal Antibody Human ELISA CSB-RA011046A0HU
IL23A IL23A Recombinant Monoclonal Antibody Human ELISA, WB CSB-RA251959A0HU
MS4A1 CD20 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A0HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A1HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human, Dog, Macaca fascicularis ELISA CSB-RA015007MA3HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA, IHC, IF CSB-RA015007MA4HU
PDCD1 PDCD1 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA240597A0HU

- 单克隆抗体

Target Product Name Species Reactivity Tested Applications Code
MS4A1 MS4A1 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000204
MS4A1 MS4A1 Monoclonal Antibody Human ELISA, IHC CSB-MA996413

- 多克隆抗体

Target Product Name Species Reactivity Tested Applications Code
CD22 CD22 Antibody Human ELISA, IHC CSB-PA004900ESR1HU
CD22 CD22 Antibody Human ELISA, WB CSB-PA070294
CD22 Phospho-CD22 (Y807) Antibody Human ELISA, WB, IHC CSB-PA070293
CD22 CD22 Antibody Human ELISA, IHC CSB-PA616669
CD22 CD22 Antibody Human ELISA, IHC CSB-PA576542
CD22 CD22 Antibody Human ELISA, WB CSB-PA828492
CD22 CD22 (Ab-807) Antibody Human ELISA, WB CSB-PA953915
CD22 Phospho-CD22 (Tyr807) Antibody Human ELISA, WB CSB-PA912726
CD28 CD28 Antibody Human ELISA, WB CSB-PA005199
CD28 Phospho-CD28 (Y218) Antibody Human, Mouse ELISA, WB CSB-PA070302
CD40 CD40 Antibody Human, Mouse ELISA, WB, IF CSB-PA004936LA01HU
CD40 CD40 Antibody Human, Mouse, Monkey ELISA, WB, IHC CSB-PA001455
CD40 Phospho-CD40 (T254) Antibody Human, Mouse ELISA, WB CSB-PA080031
CD40 CD40 Antibody Human ELISA, WB CSB-PA004936GA01HU
CD40 CD40 Antibody Human, Mouse ELISA, IHC CSB-PA215588
CD40 Phospho-CD40 (Thr254) Antibody Human, Mouse ELISA, WB CSB-PA176134
CD40LG CD40LG Antibody Human ELISA CSB-PA06005A0Rb
CD40LG CD40LG Antibody Human, Mouse, Rat ELISA, WB, IHC CSB-PA004937GA01HU
CD40LG CD40LG Antibody Human, Mouse ELISA, WB CSB-PA067336
FCGRT FCGRT Antibody Human, Mouse ELISA, WB, IHC, IF CSB-PA008545EA01HU

● ELISA试剂盒

Target Product Name Sample Types Detection Range Code
CD40LG Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E04716h
CD40 Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit Request Information CSB-EL004936MO
CD40LG Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates, cell culture supernates. 0.274 ng/ml-200 ng/ml. CSB-E04717m
CD40LG Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 1.87 ng/mL-120 ng/mL CSB-E07395r
CD28 Human soluble cluster of differentiation 28,sCD28 ELISA Kit serum, plasma, tissue homogenates 0.625 ng/mL-40 ng/mL CSB-E09296h
TNFSF13B Human B cell activation factor,BAFF ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E11912h
PDCD1 Mouse Programmed Death 1(PD-1)ELISA Kit serum, plasma, tissue homogenates, cell lysates 0.312 ng/mL-20 ng/mL CSB-E13586m
PDCD1 Human Programmed Death 1(PD-1)ELISA KIT serum, plasma, tissue homogenates, cell lysates 15.6 pg/mL-1000 pg/mL CSB-E13643h
MS4A1 Human B-lymphocyte antigen (CD20) ELISA Kit serum, plasma, tissue homogenates 3.12 ng/mL-200 ng/mL CSB-E14007h
IL12A Bovine Interleukin 12,IL-12 ELISA Kit serum, plasma, tissue homogenates 6.25 pg/mL-400 pg/mL CSB-E14010B
IL7R Human Soluble Interleukin-7 Receptor,sIL-7R ELISA Kit serum, plasma, tissue homogenates 0.78 ng/mL-50 ng/mL CSB-E14020h
IL23A Human Interleukin-23 subunit alpha(IL-23A) Elisa kit serum, plasma, cell culture supernates, tissue homogenates, cell lysates 62.5 pg/mL-4000 pg/mL CSB-E17339h
FCGRT Human IgG receptor FcRn large subunit p51(FCGRT) ELISA kit serum, plasma, tissue homogenates 15.6 pg/mL-1000 pg/mL CSB-EL008545HU
ICOSLG Human ICOS ligand(ICOSLG) ELISA kit serum, plasma, tissue homogenates 93.75 pg/mL-6000 pg/mL CSB-EL010958HU
ICOSLG Mouse ICOS ligand(ICOSLG) ELISA kit serum, plasma, tissue homogenates 62.5 pg/mL-4000 pg/mL CSB-EL010958MO
IFNA2 Human interferon alpha-2(IFNA2) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-EL011038HU
IFNA2 Mouse interferon alpha-2(IFNA2) ELISA kit serum, plasma, tissue homogenates, cell lysates 9.38 pg/mL-600 pg/mL CSB-EL011038MO
IL23A Pig Interleukin-23 subunit alpha(IL23A) ELISA kit serum, plasma, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-EL011638PI
IL7R Mouse Interleukin-7 receptor subunit alpha(IL7R) ELISA kit serum, plasma, tissue homogenates 78 pg/ml - 5000 pg/ml CSB-EL011670MO
TNFRSF13C Mouse Tumor necrosis factor receptor superfamily member 13C(TNFRSF13C) ELISA kit serum, plasma, tissue homogenates 39 pg/ml - 2500 pg/ml CSB-EL023972MO
自身免疫疾病