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自身免疫疾病系列——

克罗恩病

克罗恩病

克罗恩病(Crohn's Disease, CD)是一种慢性炎症性肠病,属于炎症性肠病的一种。该病可以影响消化道的任何部位,从口腔至肛门,但最常见于小肠末端(回肠)和大肠(结肠)。它通常表现为胃肠道的节段性炎症,可能引起腹痛、腹泻、直肠出血、体重下降、发热和疲劳等症状。

目前克罗恩病的治疗策略主要是使用药物控制炎症,并及时进行手术干预,以减轻肠损伤症状,药物研发主要集中于以下几个方向:

  • 抗TNF药物:英夫利昔单抗(Infliximab)和阿达木单抗(Adalimumab)是广泛使用的抗TNF药物,它们在克罗恩病的治疗中显示出良好的疗效和安全性。
  • JAK抑制剂:乌帕替尼(Upadacitinib)和托法替布(Tofacitinib)是新的治疗选择,特别是乌帕替尼已获批用于中重度克罗恩病的治疗,并显示出显著的疗效和安全性。
  • IL-23抑制剂:古塞奇尤单抗(Guselkumab)和利生奇珠单抗(Risankizumab)靶向IL-23的p19亚基,有效诱导和维持缓解,已在临床试验中取得积极结果。
  • CCR9拮抗剂:CCX282-B是一种新型药物,通过靶向CCR9受体,抑制肠道炎症反应,目前处于临床前研究阶段。
  • α4β7整合素抑制剂:维得利珠单抗(Vedolizumab)已获FDA批准用于克罗恩病的治疗,显示出良好的疗效和安全性。

其他正在研发中的新型药物包括针对IL-12/23轴的药物和基于基因疗法的药物,有望为克罗恩病患者提供更多的治疗选择。

华美生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,特整理了一系列与克罗恩病研究相关的热门靶点及相关试剂产品列举如下,供您选择:

克罗恩病药物靶点相关产品推荐

● 靶点蛋白

CSB-MP004848HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU),the EC50 is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control

CSB-MP004936HU1 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CSB-MP004937HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.

CSB-BP624104HU(M) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC50 is 1.818-2.170 ng/mL.

CSB-YP011664HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.

CSB-MP012474HU1 Activity Verified

Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.

CSB-MP017260HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human OSM at 2μg/mL can bind Anti-OSM recombinant antibody (CSB-RA017260MA1HU),the EC50 is 3.048-3.860 ng/mL.

CSB-MP023992HU(F2) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml can bind Anti-TNFSF15 recombinant antibody(CSB-RA023992MA1HU). The EC50 is 0.8389-0.9731 ng/mL.

Target Product Name Source Tag Info Product Code
CCR9 Recombinant Human C-C chemokine receptor type 9 (CCR9), partial E.coli N-terminal GST-tagged CSB-EP004848HU1
CCR9 Recombinant Human C-C chemokine receptor type 9 (CCR9)-VLPs (Active) Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) CSB-MP004848HU
CD226 Recombinant Human CD226 antigen (CD226), partial (Active) Mammalian cell C-terminal hFc-Myc-tagged CSB-MP618996HU
CD38 Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial Mammalian cell C-terminal hFc-tagged CSB-MP004929HU1
CD38 Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial Yeast C-terminal 6xHis-tagged CSB-YP004929HU1
CD38 Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial E.coli N-terminal GST-tagged CSB-EP004929HU2
CD4 Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial in vitro E.coli expression system N-terminal 6xHis-tagged CSB-CF004935HU1
Cd4 Recombinant Mesocricetus auratus T-cell surface glycoprotein CD4 (Cd4), partial E.coli N-terminal GST-tagged and C-terminal Strep II-tagged CSB-EP4837MRG
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal Fc-tagged CSB-AP005181HU
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) Mammalian cell C-terminal hFc-tagged CSB-MP004936HU1
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial E.coli C-terminal 6xHis-tagged CSB-EP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal hFc-tagged CSB-YP851448PI
CD40 Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial Yeast C-terminal 6xHis-tagged CSB-YP851448PIc7
CD40 Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial Baculovirus C-terminal hFc-Avi-tagged CSB-BP004936HU1
CD40LG Recombinant Macaca mulatta CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937MOW
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial E.coli N-terminal 6xHis-tagged CSB-EP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial E.coli N-terminal GST-tagged CSB-RP060054h
CD40LG Recombinant Human CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937HU1
CD40LG Recombinant Rabbit CD40 ligand (CD40LG), partial Yeast N-terminal 6xHis-tagged CSB-YP004937RB
CD40LG Recombinant Human CD40 ligand (CD40LG), partial (Active) E.coli Tag-Free CSB-AP005191HU

● 抗体

CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU
CSB-RA796695A0HU IHC

Tested Applications:
ELISA, WB, IHC

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU IF

Tested Applications:
ELISA, IF, FC

MADCAM1 Recombinant Monoclonal Antibody
CSB-RA215817A0HU
CSB-RA215817A0HU Fc

Tested Applications:
ELISA, FC

MMP9 Recombinant Monoclonal Antibody
CSB-RA014679A0HU
CSB-RA014679A0HU IHC

Tested Applications:
ELISA, IHC, FC

- 重组抗体

Target Product Name Species Reactivity Tested Applications Code
CCR9 CCR9 Recombinant Monoclonal Antibody Human, Mouse ELISA, WB, IF, IP CSB-RA004848A0HU
CCR9 CCR9 Recombinant Monoclonal Antibody Human ELISA CSB-RA004848MA1HU
CD38 CD38 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA796695A0HU
CD4 CD4 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA004935A0HU
CD40 CD40 Recombinant Monoclonal Antibody Human ELISA, IF, FC CSB-RA004936MA1HU
CXCL10 CXCL10 Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA903061A0HU
IL17A IL17A Recombinant Monoclonal Antibody Human ELISA CSB-RA624104MA1HU
IL23A IL23A Recombinant Monoclonal Antibody Human ELISA, WB CSB-RA251959A0HU
IL6 IL6 Recombinant Monoclonal Antibody Human ELISA CSB-RA011664MA1HU
ITGA4 ITGA4 Recombinant Monoclonal Antibody Human ELISA, WB CSB-RA225859A0HU
MADCAM1 MADCAM1 Recombinant Monoclonal Antibody Human ELISA, FC CSB-RA215817A0HU
MMP9 MMP9 Recombinant Monoclonal Antibody Human ELISA, IHC, FC CSB-RA014679A0HU
OSM OSM Recombinant Monoclonal Antibody Human ELISA CSB-RA017260MA1HU
PDCD1 PDCD1 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA240597A0HU

- 单克隆抗体

Target Product Name Species Reactivity Tested Applications Code
CD38 CD38 Monoclonal Antibody Human ELISA, IHC CSB-MA785760
CD4 CD4 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000228
CD4 CD4 Monoclonal Antibody,APC Conjugated Human ELISA, IF, FC CSB-MA043428
CD4 CD4 Monoclonal Antibody,Biotin Conjugated Human ELISA, IF, FC CSB-MA981329
CD4 CD4 Monoclonal Antibody,FITC Conjugated Human ELISA, IF, FC CSB-MA124048
CD4 CD4 Monoclonal Antibody,PE Conjugated Human ELISA, IF, FC CSB-MA260243
CD4 CD4 Monoclonal Antibody,PE-Cy5 Conjugated Human ELISA, IF, FC CSB-MA570802
CD4 CD4 Monoclonal Antibody,Purified Human ELISA, FC CSB-MA783233
CD4 CD4 Monoclonal Antibody,PE Conjugated Mouse ELISA, FC CSB-MA084552
IL6 IL6 Monoclonal Antibody Human ELISA, WB, IHC CSB-MA067571A0m
SELL SELL Monoclonal Antibody,FITC Conjugated Human ELISA, IF, FC CSB-MA289436
SELL SELL Monoclonal Antibody,PE Conjugated Human ELISA, IF, FC CSB-MA266548
TNF TNF Monoclonal Antibody Bovine ELISA CSB-MA084771A0m
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080271
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080272

- 多克隆抗体

Target Product Name Species Reactivity Tested Applications Code
CCR9 CCR9 Antibody Human, Mouse ELISA, IHC CSB-PA035070
CCR9 CCR9 Antibody Human, Mouse ELISA, IHC CSB-PA293047
CD226 CD226 Antibody Human ELISA, WB, IHC CSB-PA618996ESR2HU
CD226 CD226 Antibody Human ELISA, WB CSB-PA005645
CD226 Phospho-CD226 (S329) Antibody Human, Mouse, Monkey ELISA, WB, IHC, IF CSB-PA006678
CD226 CD226 Antibody Human, Mouse, Monkey ELISA, WB, IHC, IF CSB-PA006679
CD226 CD226 Antibody Human ELISA, WB CSB-PA004901GA01HU
CD226 CD226 Antibody Human ELISA, IHC CSB-PA968069
CD226 CD226 Antibody Human ELISA, IHC CSB-PA016936
CD38 CD38 Antibody Human ELISA, IHC CSB-PA004929ESR1HU
CD38 CD38 Antibody Human ELISA, WB CSB-PA005628
CD38 CD38 Antibody Human ELISA, WB CSB-PA134528
CD38 CD38 Antibody Human ELISA, WB, IHC CSB-PA926996
CD3D CD3D Antibody Human ELISA, IHC CSB-PA004930ESR1HU
CD3D CD3D Antibody Human ELISA, WB CSB-PA001452
CD3D CD3D Antibody Human ELISA, WB CSB-PA005826
CD3D CD3D Antibody Human, Mouse, Rat ELISA, WB, IF CSB-PA004930GA01HU
CD4 CD4 Antibody Human ELISA, IHC CSB-PA004935ESR2HU
CD4 Phospho-CD4 (S433) Antibody Human, Mouse ELISA, IHC, IF CSB-PA070257
CD4 CD4 Antibody Human, Mouse ELISA, WB, IHC, IF CSB-PA001453

● ELISA试剂盒

CSB-E04609m 标准曲线

Mouse IL-18 ELISA Kit
CSB-E04609m

46篇文献引用

CSB-E04639m 标准曲线

Mouse IL-6 ELISA KIT
CSB-E04639m

292篇文献引用

CSB-E08006h 标准曲线

Human MMP-9 ELISA Kit
CSB-E08006h

31篇文献引用

CSB-E04741m 标准曲线

Mouse TNF-α ELISA KIT
CSB-E04741m

381篇文献引用

Target Product Name Sample Types Detection Range Code
CD226 Human CD226 antigen(CD226) ELISA kit serum, plasma, tissue homogenates 0.9 ng/mL-60 ng/mL CSB-EL004901HU
CD38 Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit serum, plasma, tissue homogenates, cell lysates 0.9 ng/mL-60 ng/mL CSB-E09884h
CD38 Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit serum, plasma, tissue homogenates 0.625 ng/mL-40 ng/mL CSB-EL004929MO
CD4 Human cluster of differentiation 4,CD4 ELISA Kit serum, plasma 0.625 ng/mL-40 ng/mL CSB-E08956h
CD4 Rat cluster of differentiation 4,CD4 ELISA Kit serum, plasma, tissue homogenates 0.78 U/mL-50 U/mL CSB-E12928r
CD4 Chicken Cluster of Differentiation 4(CD4) ELISA Kit serum, plasma, tissue homogenates 3.125 ng/mL-800 ng/mL CSB-E13114C
CD40 Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit Request Information CSB-EL004936MO
CD40LG Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E04716h
CD40LG Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates, cell culture supernates. 0.274 ng/ml-200 ng/ml. CSB-E04717m
CD40LG Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit serum, plasma, tissue homogenates 1.87 ng/mL-120 ng/mL CSB-E07395r
CX3CL1 Human Fractalkine,FK ELISA Kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E04558h
CX3CL1 Mouse Fractalkine,FK ELISA Kit serum, plasma, cell culture supernates, tissue homogenates 125 pg/mL-8000 pg/mL CSB-E04559m
CX3CL1 Rat Fractalkine,FK ELISA Kit serum, plasma 0.312 ng/mL-20 ng/mL CSB-E04560r
CXCL10 Human interferon-inducible protein 10,IP-10 ELISA Kit serum, plasma, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-E08181h
CXCL10 Rat interferon-inducible protein 10,IP-10 ELISA Kit serum, plasma, tissue homogenates 781.25 pg/mL-50000 pg/mL CSB-E08182r
CXCL10 Mouse interferon-inducible protein 10,IP-10 ELISA Kit serum, plasma, tissue homogenates 0.312 ng/ml - 20 ng/ml CSB-E08183m
CXCL10 Monkey C-X-C motif chemokine 10(CXCL10) ELISA kit serum, plasma, tissue homogenates 62.5 pg/mL-4000 pg/mL CSB-EL006240RH
IL12A Bovine Interleukin 12,IL-12 ELISA Kit serum, plasma, tissue homogenates 6.25 pg/mL-400 pg/mL CSB-E14010B
IL13 Human Interleukin 13,IL-13 ELISA KIT serum, plasma, tissue homogenates 0.39 ng/ml-25 ng/ml. CSB-E04601h
IL13 Mouse Interleukin 13,IL-13 ELISA Kit serum, plasma, tissue homogenates 78 pg/ml - 5000 pg/ml CSB-E04602m
自身免疫疾病