IFNAR1
IFNAR1，即干扰素α和β受体亚单位1，别名Interferon beta receptor 1、interferon receptor 1、Interferon-alpha receptor、Type I interferon receptor 1。它是一种I型干扰素受体的组成部分，由人体细胞自身的基因编码。IFNAR1的作用机制主要是与IFNAR2亚单位形成异二聚体受体，与干扰素α和β结合后，激活Janus激酶(JAK)，进而激活信号转导及转录激活因子(STAT)信号通路，尤其是通过磷酸化STAT1和STAT2，形成ISGF3复合体，促进干扰素刺激基因(ISGs)的表达。在生物学意义上，IFNAR1在机体的抗病毒反应和免疫调节中发挥关键作用。它不仅参与了对病毒感染的防御机制，还与肿瘤免疫、自身免疫性疾病的发生发展有关。例如，IFNAR1介导的信号通路可以增强NK细胞的活性，促进单核细胞和巨噬细胞的功能，以及刺激树突状细胞的成熟和迁移。此外，IFNAR1的功能异常可能与某些病毒性疾病的发病机制相关，使其成为抗病毒治疗和免疫调节治疗的潜在靶点 。
热销产品
IFNAR1 Antibody (CSB-PA107635)
验证数据
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
IFNAR1 Antibodies
IFNAR1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011046GA01HU | IFNAR1 Antibody | Human | ELISA,WB |
| CSB-PA009471 | Phospho-IFNAR1 (Y466) Antibody | Human | WB, IHC, ELISA |
| CSB-PA009473 | IFNAR1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA107635 | IFNAR1 Antibody | Human | IHC,ELISA |
| CSB-RA011046A0HU | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA |
IFNAR1 Proteins
IFNAR1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011046HU1 CSB-EP011046HU CSB-BP011046HU CSB-MP011046HU CSB-EP011046HU1-B |
Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011046HU | Recombinant Human Interferon alpha/beta receptor 1 (IFNAR1) | in vitro E.coli expression system |
IFNAR1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011046MO1 CSB-EP011046MO1 CSB-BP011046MO1 CSB-MP011046MO1 CSB-EP011046MO1-B |
Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011046MO | Recombinant Mouse Interferon alpha/beta receptor 1 (Ifnar1) | in vitro E.coli expression system |
IFNAR1 Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP636729SH CSB-EP636729SH CSB-BP636729SH CSB-MP636729SH CSB-EP636729SH-B |
Recombinant Sheep Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR1 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP758824PI CSB-EP758824PI CSB-BP758824PI CSB-MP758824PI CSB-EP758824PI-B |
Recombinant Pig Interferon alpha/beta receptor 1 (IFNAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
