CD28

CD28全称为分化簇28抗原，是T细胞表面关键的共刺激受体，其晶体结构呈现典型的免疫球蛋白样二聚体构型。该蛋白通过与抗原呈递细胞表面的B7分子（CD80/CD86）结合，为T细胞活化提供第二信号，这种双信号机制决定了免疫应答的特异性与强度。在肿瘤微环境中，CD28信号缺失常导致T细胞耗竭，而过度激活则与类风湿性关节炎、系统性红斑狼疮等自身免疫疾病密切相关。目前全球已上市药物阿巴西普通过竞争性结合B7分子间接调控CD28通路，用于中重度类风湿治疗。在CAR-T细胞治疗领域，第二代产品普遍采用CD28或4-1BB作为共刺激结构域，显著提升了抗肿瘤活性。近年来针对CD28的新型双特异性抗体进入临床，既可阻断病理性的过度激活，又能定向增强抗肿瘤免疫，这种双向调节策略为免疫相关疾病的精准干预开辟了新路径。

热销产品

Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (CSB-MP004913HU1)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD28 Antibody (CSB-PA005199)

验证数据

Western Blot analysis of K562 cells using CD28 Polyclonal Antibody

Human soluble cluster of differentiation 28,sCD28 ELISA Kit (CSB-E09296h)

验证数据

货号：CSB-E09296h

规格：96T/48T

灵敏度：0.156 ng/mL

检测范围：0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD28 Antibody

CD28 Protein

CD28 ELISA Kit

CD28 Antibodies

CD28 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA005199	CD28 Antibody	Human	WB, ELISA
CSB-PA070302	Phospho-CD28 (Y218) Antibody	Human,Mouse	WB, ELISA

CD28 Proteins

CD28 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP004913HU1 CSB-EP004913HU1 CSB-BP004913HU1 CSB-EP004913HU1-B	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004913HU	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system
CSB-MP004913HU1	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial	Mammalian cell

CD28 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP004913MO1 CSB-EP004913MO1 CSB-BP004913MO1 CSB-MP004913MO1 CSB-EP004913MO1-B	Recombinant Mouse T-cell-specific surface glycoprotein CD28 (Cd28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913MO	Recombinant Mouse T-cell-specific surface glycoprotein CD28 (Cd28)	in vitro E.coli expression system

CD28 Proteins for Oryctolagus cuniculus (Rabbit)

产品货号	产品名称	来源
CSB-YP004913RB1 CSB-EP004913RB1 CSB-BP004913RB1 CSB-MP004913RB1 CSB-EP004913RB1-B	Recombinant Rabbit T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913RB	Recombinant Rabbit T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system

CD28 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP004913CH1 CSB-EP004913CH1 CSB-BP004913CH1 CSB-MP004913CH1 CSB-EP004913CH1-B	Recombinant Chicken T-cell-specific surface glycoprotein CD28 homolog (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913CH	Recombinant Chicken T-cell-specific surface glycoprotein CD28 homolog (CD28)	in vitro E.coli expression system

CD28 Proteins for Felis catus (Cat) (Felis silvestris catus)

产品货号	产品名称	来源
CSB-YP004913CA1 CSB-EP004913CA1 CSB-BP004913CA1 CSB-MP004913CA1 CSB-EP004913CA1-B	Recombinant Cat T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913CA	Recombinant Cat T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system

CD28 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP004913RA1 CSB-EP004913RA1 CSB-BP004913RA1 CSB-MP004913RA1 CSB-EP004913RA1-B	Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913RA	Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28)	in vitro E.coli expression system

CD28 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP638916BO CSB-EP638916BO CSB-BP638916BO CSB-MP638916BO CSB-EP638916BO-B	Recombinant Bovine T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli