1型糖尿病（Type 1 Diabetes Mellitus, T1DM），又称胰岛素依赖型糖尿病，是一种慢性自身免疫性疾病，因胰岛β细胞受损导致胰岛素绝对缺乏，常在儿童和青少年时期发病，但也可能影响各年龄段人群。典型症状包括多尿、多饮、多食和体重减轻，严重时可能导致酮症酸中毒等急性并发症。
1型糖尿病的治疗和研究领域涵盖了多个方面，包括胰岛素治疗、自动胰岛素输送系统（AID）、胰岛素辅助疗法、GIP/GLP-1受体激动剂等。目前其药物研发方向涵盖了免疫调节、β细胞保护和再生到特定激素受体拮抗和激活等多个方面，具体阐述如下：
- 免疫调节和炎症抑制：研究表明，通过免疫调节或抑制炎症来保护胰岛β细胞，有望延迟或阻止疾病的进展。例如，CTLA4-Ig（abatacept）作为一种免疫调节剂，在T1DM患者中使用，能够减缓β细胞功能的下降，并在停药后至少一年内保持效果 [1]。abatacept作为一种有前景的实验性药物，通过特定的免疫调节而不引起全身性免疫抑制，显示出在T1DM中的潜力 [2]。
- 胰高血糖素受体拮抗和激活：胰高血糖素在T1DM中的作用受到关注，阻断胰高血糖素受体或抑制α细胞分泌胰高血糖素成为新的治疗方向。此外，胰高血糖素样肽-1（GLP-1）系统作为治疗靶点，因其多模式作用和低低血糖倾向而受到关注 [3]。
- 内质网应激：内质网应激被认为是T1DM发病的重要病理特征，靶向病理性内质网应激的药物有望恢复胰岛β细胞的数量和质量。
- 自身抗原和细胞因子：针对T1DM中的自身抗原（如GAD65、胰岛素等）和细胞因子的治疗策略也在研究之中。这些自身抗原不仅是体液性自身免疫反应的靶蛋白，而且可能也是自身反应性T淋巴细胞的靶分子。
目前，以T淋巴细胞、B淋巴细胞、细胞因子为目标的靶向免疫治疗已获得长足进展。此外，包括SGLT抑制剂、GLP-1激动剂、免疫调节药物（包括自身抗原和抗细胞因子）、β细胞再生剂等在内的多种新药物正在临床开发中。胰岛素基因治疗也作为一种替代策略，通过在非β细胞中表达胰岛素来纠正高血糖，显示出治疗T1DM的潜力。
华美生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品，特整理了一系列与1型糖尿病研究相关的热门靶点及相关试剂产品列举如下，供您选择：
1型糖尿病在研药物靶点
1型糖尿病药物靶点相关产品推荐
● 靶点蛋白
CSB-MP004936HU1
Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.
CSB-MP004937HU3
Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.
CSB-MP006163HU1
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP009316HU1
Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
CSB-BP624104HU(M)
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Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC50 is 1.818-2.170 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU)，the EC50 is 35.80-41.82 ng/mL.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
| Target | Product Name | Source | Tag Info | Product Code |
|---|---|---|---|---|
| CD2 | Recombinant Human T-cell surface antigen CD2 (CD2), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP004894HU |
| CD274 | Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP878942HU2 |
| CD274 | Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP878942HU1 |
| CD274 | Recombinant Dog CD274 molecule (CD274), partial | Mammalian cell | C-terminal 10xHis-tagged | CSB-MP5015DO1 |
| CD274 | Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial ( (K136A)) | E.coli | N-terminal 6xHis-tagged | CSB-EP878942HU1(M) |
| CD28 | Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial | Mammalian cell | C-terminal hFc-tagged | CSB-MP004913HU1 |
| CD38 | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | Mammalian cell | C-terminal hFc-tagged | CSB-MP004929HU1 |
| CD38 | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | Yeast | C-terminal 6xHis-tagged | CSB-YP004929HU1 |
| CD38 | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | E.coli | N-terminal GST-tagged | CSB-EP004929HU2 |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005181HU |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP004936HU1 |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | E.coli | C-terminal 6xHis-tagged | CSB-EP851448PI |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal hFc-tagged | CSB-YP851448PI |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal 6xHis-tagged | CSB-YP851448PIc7 |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Baculovirus | C-terminal hFc-Avi-tagged | CSB-BP004936HU1 |
| CD40LG | Recombinant Macaca mulatta CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937MOW |
| CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004937RB |
| CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | E.coli | N-terminal GST-tagged | CSB-RP060054h |
| CD40LG | Recombinant Human CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937HU1 |
| CD40LG | Recombinant Rabbit CD40 ligand (CD40LG), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004937RB |
● 抗体
CSB-RA004936MA1HU
Tested Applications:
ELISA, IF, FC
CSB-RA787996A0HU
Tested Applications:
ELISA, WB, IF
CSB-RA259644A0HU
Tested Applications:
ELISA, WB, IHC
CSB-RA567010A0HU
Tested Applications:
ELISA, IHC
- 重组抗体
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CD274 | CD274 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA977797A0HU |
| CD274 | CD274 Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC | CSB-RA878942MA1HU |
| CD38 | CD38 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA796695A0HU |
| CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
| GCGR | GCGR Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA009316A1HU |
| IL17A | IL17A Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA624104MA1HU |
| IL23A | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA251959A0HU |
| IL6 | IL6 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA011664MA1HU |
| ITGAL | ITGAL Recombinant Monoclonal Antibody | Human | ELISA, WB, IF | CSB-RA787996A0HU |
| MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
| PCSK9 | PCSK9 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA259644A0HU |
| SELPLG | SELPLG Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA567010A0HU |
- 单克隆抗体
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CD2 | CD2 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000227 |
| CD2 | CD2 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA785710 |
| CD38 | CD38 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA785760 |
| IL1B | IL1B Monoclonal Antibody | Human | ELISA | CSB-MA065741A0m |
| IL1B | IL1B Monoclonal Antibody | Human | ELISA, WB, IHC, ICC | CSB-MA010884 |
| IL6 | IL6 Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-MA067571A0m |
| ITGAL | ITGAL Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA120024 |
| ITGAL | ITGAL Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA897229 |
| MS4A1 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000204 |
| MS4A1 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA996413 |
| TNF | TNF Monoclonal Antibody | Bovine | ELISA | CSB-MA084771A0m |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080271 |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080272 |
- 多克隆抗体
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CD2 | CD2 Antibody | Human | ELISA, IHC, IF | CSB-PA004894LA01HU |
| CD2 | CD2 Antibody | Human | ELISA, WB | CSB-PA005194 |
| CD2 | CD2 Antibody | Human | ELISA, WB | CSB-PA004894GA01HU |
| CD274 | CD274 Antibody | Human | ELISA, IHC | CSB-PA878942ESR1HU |
| CD274 | CD274 Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA004911GA01HU |
| CD28 | CD28 Antibody | Human | ELISA, WB | CSB-PA005199 |
| CD28 | Phospho-CD28 (Y218) Antibody | Human, Mouse | ELISA, WB | CSB-PA070302 |
| CD38 | CD38 Antibody | Human | ELISA, IHC | CSB-PA004929ESR1HU |
| CD38 | CD38 Antibody | Human | ELISA, WB | CSB-PA005628 |
| CD38 | CD38 Antibody | Human | ELISA, WB | CSB-PA134528 |
| CD38 | CD38 Antibody | Human | ELISA, WB, IHC | CSB-PA926996 |
| CD3D | CD3D Antibody | Human | ELISA, IHC | CSB-PA004930ESR1HU |
| CD3D | CD3D Antibody | Human | ELISA, WB | CSB-PA001452 |
| CD3D | CD3D Antibody | Human | ELISA, WB | CSB-PA005826 |
| CD3D | CD3D Antibody | Human, Mouse, Rat | ELISA, WB, IF | CSB-PA004930GA01HU |
| CD40 | CD40 Antibody | Human, Mouse | ELISA, WB, IF | CSB-PA004936LA01HU |
| CD40 | CD40 Antibody | Human, Mouse, Monkey | ELISA, WB, IHC | CSB-PA001455 |
| CD40 | Phospho-CD40 (T254) Antibody | Human, Mouse | ELISA, WB | CSB-PA080031 |
| CD40 | CD40 Antibody | Human | ELISA, WB | CSB-PA004936GA01HU |
| CD40 | CD40 Antibody | Human, Mouse | ELISA, IHC | CSB-PA215588 |
● ELISA试剂盒
| Target | Product Name | Sample Types | Detection Range | Code |
|---|---|---|---|---|
| CD274 | Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E13644h |
| CD274 | Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-EL004911MO |
| CD28 | Human soluble cluster of differentiation 28,sCD28 ELISA Kit | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-E09296h |
| CD38 | Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.9 ng/mL-60 ng/mL | CSB-E09884h |
| CD38 | Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-EL004929MO |
| CD40 | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | Request Information | CSB-EL004936MO | |
| CD40LG | Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E04716h |
| CD40LG | Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates. | 0.274 ng/ml-200 ng/ml. | CSB-E04717m |
| CD40LG | Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 1.87 ng/mL-120 ng/mL | CSB-E07395r |
| IL12A | Bovine Interleukin 12,IL-12 ELISA Kit | serum, plasma, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E14010B |
| IL17A | Mouse Interleukin 17,IL-17 ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates | 10.938 pg/ml-700 pg/ml | CSB-E04608m-IS |
| IL17A | Mouse Interleukin 17,IL-17 ELISA Kit | serum, plasma, tissue homogenates | 78 pg/ml - 5000 pg/ml | CSB-E04608m |
| IL17A | Rat Interleukin 17,IL-17 ELISA KIT | serum, plasma, tissue homogenates | 93.75 pg/mL-6000 pg/mL | CSB-E07451r |
| IL17A | Pig interleukin 17,IL-17 ELISA Kit | serum, plasma, tissue homogenates | 20 pg/mL- 800 pg/mL | CSB-E08057p |
| IL17A | Human Interleukin 17A (IL-17A/IL-17) ELISA Kit | serum, plasma, tissue homogenates | 62.5 pg/ml - 4000 pg/ml | CSB-E12819h |
| IL1B | Human Interleukin 1β,IL-1β ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates | 2.344 pg/ml-150 pg/ml | CSB-E08053h-IS |
| IL1B | Mouse Interleukin 1β,IL-1β ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates | 12.5 pg/ml-800 pg/ml | CSB-E08054m-IS |
| IL1B | Pig Interleukin 1β,IL-1β ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL-250 pg/mL | CSB-E06782p |
| IL1B | Rabbit Interleukin 1β,IL-1β ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL-500 pg/mL | CSB-E06900Rb |
| IL1B | Human Interleukin 1β,IL-1β ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/ml - 500 pg/ml | CSB-E08053h |
药物研发解决方案
参考文献：
[1] Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes Care, 2014.
[2] CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes. Expert Opin Investig Drugs, 2020.
[3] GLP-1 as a target for therapeutic intervention. Curr Opin Pharmacol, 2016.
