NECTIN4
NECTIN4，即连接蛋白细胞粘附分子4，别名LNIR、PRR4、EDSS1、PVRL4。NECTIN4蛋白是一种跨膜细胞粘附分子，属于免疫球蛋白样分子的Nectins家族，具有一个IGV环和两个IGC环组成的细胞外结构区域、跨膜结构域以及含有afadin结合基序的细胞质结构域。NECTIN4通过与其他Nectins分子的相互作用参与细胞间粘附，在相邻细胞之间形成物理连接，对于实现细胞间通讯、迁移和其他重要的细胞过程至关重要。
NECTIN4在多种肿瘤中过表达，如尿路上皮癌、乳腺癌、胰腺癌等，而在正常组织中的表达较低。NECTIN4的过表达与肿瘤细胞的增殖、分化、迁移、侵袭等过程相关，主要通过激活PI3K/Akt途径促进肿瘤细胞的增殖和迁移，是肿瘤治疗的潜在靶点，特别是抗体药物偶联物（ADC）治疗策略中的重要靶点。
热销产品
Recombinant Human Nectin-4 (NECTIN4), partial (Active) (CSB-MP822274HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized NECTIN4 at 2 μg/ml can bind anti-NECTIN4 antibody（CSB-RA822274A0HU）（enfortumab vedotin-like）, the EC50 is 0.6029-0.7837 ng/mL.
NECTIN4 Recombinant Monoclonal Antibody (CSB-RA822274A0HU)
验证数据
The Binding Activity of NECTIN4 with Anti-NECTIN4 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human NECTIN4(CSB-MP822274HU) at 2 μg/mL can bind Anti-NECTIN4 recombinant antibody, the EC50 is 0.6029-0.7837 ng/mL.
NECTIN4 Antibodies
NECTIN4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA060216 | PVRL4 Antibody | Human | WB, ELISA |
| CSB-PA190585 | PVRL4 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA232987 | PVRL4 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA822274LA01HU | NECTIN4 Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-PA822274LB01HU | NECTIN4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA822274LC01HU | NECTIN4 Antibody, FITC conjugated | Human | |
| CSB-PA822274LD01HU | NECTIN4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA822274A0HU | NECTIN4 Recombinant Monoclonal Antibody | Human | ELISA |
NECTIN4 Proteins
NECTIN4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP702045XBF CSB-EP702045XBF CSB-BP702045XBF CSB-MP702045XBF CSB-EP702045XBF-B |
Recombinant Xenopus tropicalis Poliovirus receptor-related protein 4 (pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP707822BO CSB-EP707822BO CSB-BP707822BO CSB-MP707822BO CSB-EP707822BO-B |
Recombinant Bovine Poliovirus receptor-related protein 4 (PVRL4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial | Yeast |
| CSB-EP822274HU CSB-BP822274HU CSB-EP822274HU-B |
Recombinant Human Nectin-4 (NECTIN4), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP005571HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
| CSB-MP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
NECTIN4 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP844423MO CSB-EP844423MO CSB-BP844423MO CSB-MP844423MO CSB-EP844423MO-B |
Recombinant Mouse Poliovirus receptor-related protein 4 (Pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
