ITGAL
ITGAL对应的蛋白全称为整合素αL，也被称为CD11a或LFA-1α，常与β2亚基结合形成淋巴细胞功能相关抗原-1（LFA-1）。这种蛋白在免疫细胞表面广泛表达，尤其在T细胞和中性粒细胞中活跃，通过介导细胞间黏附参与炎症反应、免疫细胞迁移及抗原提呈等过程。其功能异常常与自身免疫疾病相关，例如多发性硬化症、类风湿性关节炎患者的LFA-1活性异常升高，导致免疫细胞过度攻击自身组织。此外，该蛋白在器官移植排斥反应和某些白血病中也显示出调控作用。
近年来，针对LFA-1的抑制剂成为药物开发热点。早期单抗药物如奥法木单抗曾用于治疗复发型多发性硬化，但因疗效局限逐渐淡出。小分子拮抗剂如BMS-817399在动物模型中显示出抑制炎症浸润潜力，目前处于临床前研究阶段。部分药物因阻断LFA-1可能引发感染风险，研究者正探索局部给药或变构调节策略以平衡疗效与安全性。在肿瘤免疫领域，联合LFA-1调控与其他免疫检查点抑制剂的方案也进入早期探索。
热销产品
Recombinant Human Integrin alpha-L (ITGAL), partial (CSB-MP011875HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of ITGAL was greater than 90% as determined by SEC-HPLC
ITGAL Recombinant Monoclonal Antibody (CSB-RA787996A0HU)
验证数据
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: ITGAL antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 129, 135, 120 kDa
Observed band size: 130 kDa
Immunofluorescence staining of THP-1 cell with CSB-RA787996A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 490-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ITGAL Antibodies
ITGAL for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011875LA01MO | Itgal Antibody | Mouse | ELISA |
ITGAL for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006157 | ITGAL Antibody | Human | WB, ELISA |
| CSB-PA932598 | ITGAL Antibody | Human | ELISA,IHC |
| CSB-PA011875LA01HU | ITGAL Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA011875LB01HU | ITGAL Antibody, HRP conjugated | Human | ELISA |
| CSB-RA787996A0HU | ITGAL Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
ITGAL Proteins
ITGAL Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP011875HU CSB-EP011875HU-B |
Recombinant Human Integrin alpha-L (ITGAL), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | E.coli |
| CSB-YP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Yeast |
| CSB-MP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Mammalian cell |
ITGAL Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | Yeast |
| CSB-EP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | E.coli |
| CSB-BP011875MO CSB-MP011875MO CSB-EP011875MO-B |
Recombinant Mouse Integrin alpha-L (Itgal), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAL Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011875BO CSB-EP011875BO CSB-BP011875BO CSB-MP011875BO CSB-EP011875BO-B |
Recombinant Bovine Integrin alpha-L (ITGAL), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
