AREG
AREG（Amphiregulin），全称双向调节素，也被称为双调蛋白或表皮生长因子受体配体，是表皮生长因子家族的重要成员。AREG通过与细胞表面的EGFR蛋白结合，激活下游信号网络，参与调控细胞增殖、分化及组织修复过程。研究发现，AREG在多种恶性肿瘤中异常活跃，例如结直肠癌、非小细胞肺癌和三阴性乳腺癌，其过表达会加速肿瘤生长、转移及化疗耐药。AREG蛋白在哮喘、特应性皮炎等慢性炎症疾病中可增强免疫细胞活性，并与特发性肺纤维化的异常成纤维细胞活化密切相关。目前针对AREG相关通路的治疗药物以EGFR靶向药为主，如西妥昔单抗、帕尼单抗等已用于临床，但直接抑制AREGF的药物研发仍处于早期阶段。近年来，联合靶向AREG与免疫检查点的疗法在动物模型中显示出协同抗肿瘤效果，为克服EGFR抑制剂耐药提供了新方向。
热销产品
AREG Antibody (CSB-PA11339A0Rb)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA11339A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA11339A0Rb at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA11339A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
AREG Antibodies
AREG for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001986GA01HU | AREG Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA006314 | AREG Antibody | Human | WB, ELISA |
| CSB-PA441346 | AREG Antibody | Human | ELISA,WB |
| CSB-PA694774 | AREG Antibody | Human | ELISA,WB |
| CSB-PA11339A0Rb | AREG Antibody | Human | ELISA, IHC, IF |
| CSB-PA11339B0Rb | AREG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11339C0Rb | AREG Antibody, FITC conjugated | Human | |
| CSB-PA11339D0Rb | AREG Antibody, Biotin conjugated | Human | ELISA |
AREG Proteins
AREG Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001986HU1 CSB-EP001986HU1 CSB-BP001986HU1 CSB-MP001986HU1 CSB-EP001986HU1-B |
Recombinant Human Amphiregulin (AREG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP002641HU | Recombinant Human Amphiregulin protein (AREG), partial (Active) | E.Coli |
| CSB-CF001986HU | Recombinant Human Amphiregulin (AREG) | in vitro E.coli expression system |
AREG Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001986MO1 CSB-EP001986MO1 CSB-BP001986MO1 CSB-MP001986MO1 CSB-EP001986MO1-B |
Recombinant Mouse Amphiregulin (Areg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001986MO | Recombinant Mouse Amphiregulin (Areg) | in vitro E.coli expression system |
AREG Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001986RA1 CSB-EP001986RA1 CSB-BP001986RA1 CSB-MP001986RA1 CSB-EP001986RA1-B |
Recombinant Rat Amphiregulin (Areg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001986RA | Recombinant Rat Amphiregulin (Areg) | in vitro E.coli expression system |
AREG ELISA Kit
AREG ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04496h | Human keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit | serum, plasma | 1.1 pg/mL |
AREG ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E07299r | Rat keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit | serum, plasma, tissue homogenates | 0.31 pg/mL |
