Recombinant Mouse Amphiregulin (Areg), partial

1. Amphiregulin plays an important role in promoting cardiac fibrosis after myocardial infarction partly though activating the EGFR pathway. PMID: 29349588
2. The studies indicate that HIF2-alpha induces myocardial AREG expression in cardiac myocytes, which increases myocardial ischemia tolerance. PMID: 29483579
3. Areg transgenic mice showed less adipose tissue mass with increased mRNA expression levels of Tnf-alpha and peroxisome proliferator-activated receptor gamma coactivator 1 alpha and delayed white adipose tissue development during the convalescent stage in a dextran sodium sulfate-induced colitis model. PMID: 29341420
4. Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function. PMID: 27040371
5. activated alveolar macrophages also exerted a protective effect on the lung tissues by producing high-level amphiregulin in lipopolysaccharide-induced acute lung injury PMID: 26808632
6. AREG overexpression in osteoblasts induces a transient high bone mass phenotype in the trabecular compartment of the appendicular skeleton by a growth-related, non-cell autonomous mechanism PMID: 26103093
7. AREG-silenced keratinocytes plays an important role in regulation cell proliferation. PMID: 26802239
8. Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection. PMID: 26216935
9. Areg may have a role in classically activated macrophages PMID: 26365345
10. After activation with IL-33, expression of AREG is a dominant functional signature of gut-associated IL-33-dependent group 2 innate lymphoid cells. The frequency and number of AREG-expressing ILC2s increases following intestinal injury. PMID: 26243875
11. AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH, suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD. PMID: 25744849
12. hormones and/or factors in addition to E that upregulate AREG can promote mammary gland development and have the potential to affect breast cancer risk associated with pubertal mammary gland development PMID: 23705924
13. Our data show that AREG is essential for ultraviolet therapy-induced contact hypersensitivity suppression. PMID: 25089660
14. Pre-maturation with cAMP modulators in conjunction with EGF-like peptides during in vitro maturation enhances mouse oocyte developmental competence. PMID: 24488930
15. During high-pressure ventilation, Nrf2 becomes activated and induces AREG, leading to a positive feedback loop between Nrf2 and AREG, which involves the p38 MAPK and results in the expression of cytoprotective genes. PMID: 24921206
16. AREG plays pro-neoplastic roles in colorectal carcinogenesis PMID: 23263765
17. Amphiregulin expression is regulated by the androgen/androgen receptor pathway. PMID: 23415714
18. Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. PMID: 23333074
19. Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling, which has implications in ADPKD cell proliferation PMID: 22570239
20. AR, or AR-activated EGFR signaling, is a potential therapeutic target for idiopathic pulmonary fibrosis associated with TGF-beta1 activation. PMID: 23086930
21. The data showed that STAT6 regulated Alternaria-induced lung natrual-helper-cell proliferation and expression of amphiregulin. PMID: 22865552
22. data demonstrate that AREG-dependent EGFR signaling in airway epithelial cells contributes to MCM in naphthalene-induced lung injury. We conclude that AREG may represent a determinant of nonallergic chronic lung diseases complicated by MCM PMID: 22493011
23. Lung tumor-associated dendritic cell-derived amphiregulin increased cancer progression. PMID: 21742971
24. This study implicates that EREG mediates signals downstream of Areg mRNA expression and that EGFR-ERBB2 signals contributes to regulation of ovulation process. PMID: 21237132
25. A TLR-->MyD88-->AREG/EREG-->EGFR signaling pathway is represented in nonhematopoietic cells of the intestinal tract, responds to microbial stimuli once barriers are breached, and mediates protection against dextran sulfate sodium-induced colitis. PMID: 21041656
26. ATP released from tumor cells might exert a tumorigenic action by stimulating the secretion of AREG from dendritic cells. PMID: 20651071
27. is not essential for induction of acute airway inflammation PMID: 20414053
28. AREG plays a critical role in testinal epithelial growth. PMID: 20534719
29. Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner. PMID: 20308529
30. Results describe the role of amphiregulin in an experimental model of bleomycin-induced pneumopathy in mice. PMID: 19915156
31. Data show that Dmp1 directly bound to the genomic loci of Areg, Tsp-1, JunB and Egr1. PMID: 19816943
32. These data demonstrate AREG mediates the function of a subset of mammary progenitor cells in vitro. PMID: 19913532
33. identified amphiregulin as a key regulator of hepatic acute-phase protein gene expression during inflammation and liver regeneration PMID: 19815304
34. Amphiregulin is a mitogen for adult neural stem cells. PMID: 12205669
35. amphiregulin binds to EGF receptor and has a role in stimulation of lung epithelial cells upon exposure to tobacco smoke PMID: 12711607
36. epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin are paracrine mediators that propagate the LH signal throughout the ovulatory follicle PMID: 14726596
37. Castration leads to adaptive increase in the concentrations of a subset of growth factors from the EGF network in the androgen sensitive CWR22 prostate cancer xenograft. PMID: 15651060
38. amphiregulin is a protective factor induced in response to liver damage PMID: 15753092
39. ADAM17 plays a crucial role in mammary morphogenesis by releasing amphiregulin from mammary epithelial cells PMID: 16079154
40. findings show that T helper 2 (TH2) cells express amphiregulin; expression of amphiregulin by TH2 cells provides a newly recognized link between type 2 adaptive immune response & proliferation of gut epithelial cells that aids helminth parasite removal PMID: 17170297
41. amphiregulin is an important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation, but not for any earlier or later developmental stages PMID: 17369357
42. The absence of amphiregulin promoted the rapid emergence of spasmolytic polypeptide-expressing metaplasia in response to oxyntic atrophy. PMID: 17484876
43. Amphiregulin plays a specific role in liver fibrosis. Amphiregulin may contribute to the expression of fibrogenic mediators, as well as to the growth and survival of fibrogenic cells. PMID: 18634036
44. findings identify Amphiregulin as a factor for resistance of glioma cells to delta9-Tetrahydrocannabinol induced apoptosis PMID: 19229996
45. AR-/- mice develop spasmolytic polypeptide expression metaplasia, which gives rise to goblet cell intestinal metaplasia and invasive fundic dysplastic lesions. PMID: 19230855
46. Data observed that the expression of amphiregulin, betacellulin and epiregulin was significantly increased in young erythropoietic protoporphyria mice when compared to aged-matched controls in all genetic backgrounds. PMID: 19267999
47. EGFR ligands (including AREG) are protective in acute lung injury and increase more in mice deficient in Mt1/2 PMID: 16166738

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KEGG: mmu:11839

STRING: 10090.ENSMUSP00000031325

UniGene: Mm.8039