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  4. Recombinant Rat Stathmin-2 (Stmn2)

Recombinant Rat Stathmin-2 (Stmn2)

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  • 中文名称：
    大鼠Stmn2重组蛋白
  • 货号：
    CSB-EP022858RA
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Stmn2
  • Uniprot No.：
    P21818
  • 别名：
    (Superior cervical ganglion-10 protein)(Protein SCG10)
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    26.7 kDa
  • 表达区域：
    1-179aa
  • 氨基酸序列
    MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEGRRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Stmn2 Proteins

靶点详情

  • 功能：
    Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
  • 基因功能参考文献：
    1. Overexpression of SCG10 is associated with Liver Fibrosis. PMID: 20802173
    2. KBP-depleted PC12 cells were defective in nerve growth factor-induced differentiation and neurite outgrowth, suggesting that KBP is required for cell differentiation and neurite development. PMID: 20621975
    3. Results show that JLP negatively regulates NGF-induced neurite outgrowth by decreasing the level of phosphorylated SCG10. PMID: 19959466
    4. age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction. PMID: 20106964
    5. The microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) was found to directly interact with RGSZ1 in the yeast system, and this interaction was further verified using direct binding assays. PMID: 11882662
    6. The transcription of SCG10 in vivo is regulated by long-lasting synaptic activity and may contribute to the maintenance of long-term synaptic plasticity via a presynaptic remodeling mechanism PMID: 12878703
    7. These results suggest that SCG10 may play a role in the maintenance of synaptic plasticity. PMID: 14741408
    8. SCG10 serves as an important regulatory factor of growth cone motility by enhancing microtubule dynamics, possibly through increasing the catastrophe frequency PMID: 16838365
    9. in specific biological conditions, palmitoylation of stathmin proteins might be able to control their targeting to express their functional activities at appropriate subcellular sites. PMID: 18422486
    10. SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. PMID: 18996843

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, axon. Membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Endosome. Cell projection, lamellipodium.
  • 蛋白家族：
    Stathmin family
  • 组织特异性：
    Expressed in neurons (at protein level). Present in growth cones and abundant in developing neurons.
  • 数据库链接：

    KEGG: rno:84510

    STRING: 10116.ENSRNOP00000015720

    UniGene: Rn.34335

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