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  4. Recombinant Rat Protransforming growth factor alpha (Tgfa)

Recombinant Rat Protransforming growth factor alpha (Tgfa)

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  • 中文名称：
    大鼠Tgfa重组蛋白
  • 货号：
    CSB-EP360628RA
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Tgfa
  • Uniprot No.：
    P01134
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    30.1 kDa
  • 表达区域：
    24-159aa
  • 氨基酸序列
    ENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-KSI-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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靶点详情

  • 功能：
    TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
  • 基因功能参考文献：
    1. 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
    2. Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
    3. results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
    4. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
    5. TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
    6. TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
    7. TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
    8. study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
    9. mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
    10. TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584

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  • 亚细胞定位：
    [Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: rno:24827

    STRING: 10116.ENSRNOP00000054248

    UniGene: Rn.9952

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