Rat transforming growth factor α,TGF-α ELISA Kit
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中文名称：大鼠转化生长因子α(TGF-α)酶联免疫试剂盒
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货号：CSB-E07289r
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规格：96T/48T
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价格：￥3900/￥2500
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其他：
产品详情
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产品描述：大鼠转化生长因子α(TGF-α)酶联免疫试剂盒（CSB-E07289r）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的TGFA含量。TGFA即转化生长因子α，是表皮生长因子家族成员。它可与表皮生长因子受体结合，激活下游信号通路，参与细胞的增殖、分化、迁移等过程。其异常表达与肿瘤等疾病的发生发展密切相关，是药物研发的潜在靶点。试剂盒检测范围为7.8 pg/ml-500pg/ml，特别适用于动物模型中的创伤修复机制探究、肿瘤微环境研究或药理学实验中生物标志物动态监测。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit
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缩写：
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Uniprot No.：
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种属：Rattus norvegicus (Rat)
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样本类型：serum, plasma, tissue homogenates
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检测范围：7.8 pg/ml-500pg/ml
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灵敏度：1.95 pg/ml
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Signal Transduction
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测定原理：quantitative
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测定方法：Sandwich
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线性度：
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数据处理：
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货期：3-5 working days
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靶点详情
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功能：TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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基因功能参考文献：
- 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
- Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
- results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
- A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
- TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
- TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
- TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
- study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
- mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
- TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584
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亚细胞定位：[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
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数据库链接：
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