TGFA

TGFA全称为转化生长因子α，是一种表皮生长因子家族成员，常被称为TGF-alpha或TDGF。该蛋白通过与细胞表面的表皮生长因子受体结合，触发细胞增殖、分化及迁移，广泛参与胚胎发育、组织修复等生理过程。TGF-α的异常表达与多种癌症密切相关，例如乳腺癌、结直肠癌及肺癌中常见其水平升高，可能通过过度激活细胞生长信号导致肿瘤恶化。此外，该蛋白在炎症性肠病、银屑病等慢性炎症疾病中也显示出促炎作用。
近年来，针对TGF-α相关通路的药物研发取得进展，例如EGFR抑制剂厄洛替尼、吉非替尼已用于非小细胞肺癌治疗，单抗药物西妥昔单抗则在结直肠癌中展现疗效。部分研究正探索联合用药策略，例如将EGFR靶向药与免疫检查点抑制剂结合，以克服耐药性问题。与此同时，科学家也在开发特异性更高的双特异性抗体，试图精准阻断TGF-α与其受体的相互作用，相关临床试验已进入早期阶段。

热销产品

TGFA Antibody (CSB-PA07294A0Rb)

验证数据

Western blot
All lanes: TGFA antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 18, 17 kDa
Observed band size: 30, 35 kDa

Immunofluorescent analysis of Hela cells using CSB-PA07294A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA07294A0Rb at dilution of 1:100

Human transforming growth factor α,TGF-α ELISA Kit (CSB-E04724h)

验证数据

货号：CSB-E04724h

规格：96T/48T

灵敏度：

检测范围：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TGFA Antibody

TGFA Protein

TGFA ELISA Kit

TGFA Antibodies

TGFA for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA07294A0Rb	TGFA Antibody	Human	ELISA, WB, IHC, IF
CSB-PA799735	TGFA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA004275	TGFA Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA582653	TGFA Antibody	Human,Mouse,Rat	ELISA,IHC

TGFA Proteins

TGFA Proteins for Ovis aries (Sheep)

产品货号	产品名称	来源
CSB-YP023445SH	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	Yeast
CSB-EP023445SH	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	E.coli
CSB-BP023445SH CSB-MP023445SH CSB-EP023445SH-B	Recombinant Sheep Protransforming growth factor alpha (TGFA), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Oryctolagus cuniculus (Rabbit)

产品货号	产品名称	来源
CSB-YP023445RB CSB-EP023445RB CSB-BP023445RB CSB-MP023445RB CSB-EP023445RB-B	Recombinant Rabbit Transforming growth factor alpha (TGFA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP023445MO CSB-EP023445MO CSB-BP023445MO CSB-MP023445MO CSB-EP023445MO-B	Recombinant Mouse Protransforming growth factor alpha (Tgfa), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TGFA Proteins for Macaca mulatta (Rhesus macaque)

产品货号	产品名称	来源
CSB-YP023445MOW1 CSB-EP023445MOW1 CSB-BP023445MOW1 CSB-MP023445MOW1 CSB-EP023445MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) Protransforming growth factor alpha (TGFA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023445MOW	Recombinant Macaca mulatta (Rhesus macaque) Protransforming growth factor alpha (TGFA)	in vitro E.coli expression system

TGFA Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP023445HU1 CSB-EP023445HU1 CSB-BP023445HU1 CSB-MP023445HU1 CSB-EP023445HU1-B	Recombinant Human Protransforming growth factor alpha (TGFA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023445HU	Recombinant Human Protransforming growth factor alpha (TGFA)	in vitro E.coli expression system
CSB-EP072944h CSB-EP072944h-B	Recombinant Human Protransforming growth factor alpha (TGFA)	E.coli In Vivo Biotinylation in E.coli

TGFA Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP360628RA CSB-BP360628RA CSB-MP360628RA CSB-EP360628RA-B	Recombinant Rat Protransforming growth factor alpha (Tgfa), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli