Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

1. these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity. PMID: 29518903
2. these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies following skin transplantation PMID: 26924526
3. The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in mice with LPS-induced acute lung inflammation. PMID: 28164546
4. Dendritic cells require BTLA and HVEM to actively adjust tolerizing T cell responses under steady-state conditions. PMID: 27793593
5. these data indicate that CCR7 and BTLA cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA-expressing counterparts that show a more immunocompetent or immunotolerant phenotype PMID: 28393074
6. this study shows that miR-155 is involved in the inhibition of BTLA during CD4+ T cell activation PMID: 27350630
7. Our findings indicate that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression, rather than attenuating IL-17 production, in dextran sulfate sodium-induced colitis. PMID: 25973010
8. This study uncovers a BTLA-mediated strategy used by the host that permits Listeria proliferation to enable increasing T cell responses for long-term protection. PMID: 25011109
9. results support a model whereby BTLA on innate leukocytes is triggered by HVEM and delivers negative signals into BTLA(+) cells, thereby interfering with the protective immune response to this intestinal parasite. PMID: 25595777
10. by coordinating expression of BTLA, RORgammat and IL-7 balance suppressive and activation stimuli to regulate gammadelta T cell homeostasis and inflammatory responses PMID: 24315996
11. BTLA promotes the pathogenesis of virus-induced fulminant hepatitis by enhancing macrophage viability and function. Targeting BTLA may be a novel strategy for the treatment of FH. PMID: 22637698
12. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. PMID: 23479601
13. These findings support role for BTLA and/or HVEM as potential, novel diagnostic markers of innate immune response/status and as therapeutic targets of sepsis. PMID: 22459947
14. Combined blockade of BTLA and herpesvirus entry mediator (HVEM) does not inhibit donor T cell infiltration into graft-versus-host reaction organs; instead, it decreases the functional activity of the alloreactive T cells. PMID: 22490863
15. During increased resistance to malaria infection, BTLA regulates production of proinflammatory cytokines in a T cell-intrinsic way, while B cells intrinsically regulate the production of nonlethal Plasmodium yoelii 17NL-specific antibodies. PMID: 21998455
16. BTLA receptor is a potential immunoregulatory target for the modulation of cytotoxic T-lymphocyte-mediated PMID: 21978997
17. dichotomous functions of BTLA in GVHD to serve as a costimulatory ligand of HVEM and to transmit inhibitory signal as a receptor PMID: 21220749
18. The effect of the B and T lymphocyte attenuator (BTLA; CD272) on cluster of differentiation (CD)4(+) T cell-mediated corneal immunopathology during murine herpetic stromal keratitis, was investigated. PMID: 21042564
19. Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression. PMID: 21078889
20. BTLA suppresses IgG2a and IgG2b production in vivo by inhibiting interleukin (IL)-21 production from follicular T helper (Th) cells. PMID: 20660710
21. The subcellular localization of BTLA in mouse T cells in a steady state, as well as upon activation, was examined. PMID: 19892849
22. The extracellular domain of BTLA binds herpesvirus entry mediator (HVEM), blocks BTLA-HVEM interactions and significantly improves antitumor immunity in cervical cancer when combined with heat shock protein (HSP)70 vaccine. PMID: 19923459
23. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). PMID: 12796776
24. BTLA is expressed by all mature lymphocytes, splenic macrophages, and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. PMID: 15128774
25. Binding of HVEM to BTLA attenuates T cell activation, identifying HVEM/BTLA as a coinhibitory receptor pair. PMID: 15647361
26. existence of three distinct BTLA alleles among 23 murine strains, differing both in Ig domain structure and cellular distribution of expression on lymphoid subsets PMID: 15749870
27. BTLA adds to the growing list of cell surface proteins that are potential targets to down-modulate T cell function. PMID: 16272294
28. these receptors are critical determinants of the duration of allergic airway inflammation PMID: 16547224
29. BTLA had a regulatory effect on the expression of B7 on dendritic cells. PMID: 16805995
30. mice deficient in full-length BTLA or its ligand, herpesvirus entry mediator, had increased number of memory CD8(+) T cells PMID: 17206146
31. BTLA inhibits antigen-induced eosinophil recruitment into the airways by preventing IL-5 production from Th2 cells. PMID: 17541277
32. These results suggest that BTLA functions to regulate T-cell signaling by controlling the phosphorylated form of TCRzeta accumulation in the lipid raft. PMID: 17607320
33. BTLA-herpesvirus entry mediator (HVEM) interactions are functionally involved in T cell regulation during Plasmodium berghei strain ANKA blood-stage malaria and regulate sequestration of T cells in brain capillaries. PMID: 17785848
34. The LTbetaR and HVEM-BTLA pathways form an integrated signaling network regulating DC homeostasis. PMID: 18097025
35. BTLA employs a conserved binding mode for herpesvirus entry mediator recognition. PMID: 18178834
36. HVEM triggers inhibitory signals by acting as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member. PMID: 18519647
37. BTLA plays an important role in the maintenance of immune tolerance and the prevention of autoimmune diseases. PMID: 18668554
38. role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen PMID: 18713967
39. demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo PMID: 19342624
40. B and T lymphocyte attenuator (BTLA) coinhibitory signaling of natural killer T (NKT) cells is required to temper early inflammation in a model of acute hepatitis. PMID: 19535622
41. role in down-modulating immune responses[REVIEW] PMID: 19567411
42. engagement of the newly discovered coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) is critical for negatively regulating early host immunity against intracellular bacteria. PMID: 19587015
43. the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands expressed in the surrounding microenvironment, thus helping maintain T cells in the naive state. PMID: 19915044
44. BTLA functions as the inhibitory coreceptor of NKT cells PMID: 19949073

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Cell membrane; Single-pass type I membrane protein.

Expressed in splenic T- and B-cells as well as lymph node tissues but very weakly in somatic tissues. Also expressed in macrophages, NK cells and dendritic cells. A polymorphic tissue distribution between several strains is seen.

KEGG: mmu:208154

STRING: 10090.ENSMUSP00000067877

UniGene: Mm.38199