PTDSS1
PTDSS1（磷脂酰丝氨酸合成酶1）是细胞内磷脂代谢的关键酶，也被称为PSS1或PTDSS。该蛋白通过催化丝氨酸与CDP-二酰基甘油的结合反应，在内质网中合成磷脂酰丝氨酸（PS），后者是细胞膜的重要组分。PS不仅参与膜结构的动态平衡，还在凋亡细胞表面暴露时触发免疫清除信号，并与凝血因子活化、突触可塑性等生理过程相关。近年来研究发现，PTDSS1基因突变与遗传性小脑共济失调2型（SCA2）及Lenz-Majewski综合征相关，其表达异常可能影响神经细胞膜稳定性。在肿瘤领域，PTDSS1过表达被证实通过改变细胞膜磷脂组成促进肝癌、乳腺癌侵袭转移。针对该靶点的药物研发尚处早期，已有研究尝试利用小分子抑制剂干扰PS合成通路，或通过调控PTDSS1表达增强化疗药物敏感性。2021年《自然·化学生物学》报道了首个选择性靶向PTDSS1的化合物探针，为相关疾病治疗提供了新思路。
热销产品
Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial (CSB-RP043054h)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PTDSS1 Antibody (CSB-PA04305A0Rb)
验证数据
Western Blot
Positive WB detected in: 293T whole cell lysate(20µg), K562 whole cell lysate(20µg), HepG2 whole cell lysate(20µg), MCF7 whole cell lysate(20µg
All lanes: PTDSS1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 56,39,35 kDa
Observed band size: 35 kDa
Exposure time: 60s
IHC image of CSB-PA04305A0Rb diluted at 1:150 and staining in paraffin-embedded humanpancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
PTDSS1 Antibodies
PTDSS1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA04305A0Rb | PTDSS1 Antibody | Human | ELISA,WB, IHC |
PTDSS1 Proteins
PTDSS1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018962HU CSB-EP018962HU CSB-BP018962HU CSB-MP018962HU CSB-EP018962HU-B |
Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP043054h | Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial | E.coli |
