LY75
LY75蛋白全称为淋巴细胞抗原75，又名DEC-205或CD205，是C型凝集素受体家族成员。这种跨膜蛋白主要在树突状细胞表面富集，能高效识别病原体相关分子模式，通过内吞作用将抗原物质转运至溶酶体加工，随后与MHC-II分子结合呈递给CD4+T细胞，在启动适应性免疫应答中起核心作用。LY75表达异常与黑色素瘤、三阴性乳腺癌等恶性肿瘤进展相关，高表达DEC-205的肿瘤细胞可能通过逃避免疫监视促进转移。在感染性疾病中，HIV病毒可劫持该蛋白作为入侵宿主细胞的通道。基于其抗原呈递特性，科研人员开发了抗DEC-205单克隆抗体偶联NY-ESO-1肿瘤抗原的疫苗CDX-1401，该药物已完成针对晚期实体瘤的Ⅰ/Ⅱ期临床试验，数据显示能显著激活肿瘤特异性T细胞反应。另有研究将其与TLR3配体联合使用，增强抗病毒免疫效果，为新型免疫佐剂设计提供了方向。
热销产品
LY75 Antibody (CSB-PA013251ESR1HU)
验证数据
Western blot
All lanes: LY75 antibody IgG at 1.57μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 199, 216, 20, 210 kDa
Observed band size: 199 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013251ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA013251ESR1HU at dilution of 1:100
LY75 Antibodies
LY75 for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA013251HA01MO | Ly75 Antibody | Mouse | ELISA |
LY75 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA947833 | LY75 Antibody | Human | ELISA,WB |
| CSB-PA009886 | LY75 Antibody | Human | WB, ELISA |
| CSB-PA171204 | LY75 Antibody | Human | ELISA,IHC |
| CSB-PA013251ESR1HU | LY75 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA013251ESR2HU | LY75 Antibody | Human | ELISA, IHC |
LY75 Proteins
LY75 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013251HU CSB-EP013251HU CSB-BP013251HU CSB-MP013251HU CSB-EP013251HU-B |
Recombinant Human Lymphocyte antigen 75 (LY75), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LY75 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013251MO CSB-BP013251MO CSB-MP013251MO CSB-EP013251MO-B |
Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013251MO | Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial | E.coli |
LY75 Proteins for Mesocricetus auratus (Golden hamster)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013251MRG CSB-EP013251MRG CSB-BP013251MRG CSB-MP013251MRG CSB-EP013251MRG-B |
Recombinant Mesocricetus auratus Lymphocyte antigen 75 (LY75), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
