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  4. Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial

Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial

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  • 中文名称：
    小鼠Ly75重组蛋白
  • 货号：
    CSB-EP013251MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013251MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Ly75.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013251MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Ly75.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Ly75
  • Uniprot No.：
    Q60767
  • 别名：
    Ly75; Cd205; Lymphocyte antigen 75; Ly-75; DEC-205; CD antigen CD205
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    25.2kDa
  • 表达区域：
    28-211aa
  • 氨基酸序列
    SESSGNDPFTIVHENTGKCIQPLSDWVVAQDCSGTNNMLWKWVSQHRLFHLESQKCLGLDITKATDNLRMFSCDSTVMLWWKCEHHSLYTAAQYRLALKDGYAVANTNTSDVWKKGGSEENLCAQPYHEIYTRDGNSYGRPCEFPFLIGETWYHDCIHDEDHSGPWCATTLSYEYDQKWGICLL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The recombinant Mouse Ly75 protein is encoded by the gene of Ly75 (28-211aa). The gene of Ly75 was cloned in a system (E.coli) that supported the expression of Ly75. Modification of Ly75 by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis tag in the production. The purity is 90% determined by SDS-PAGE.

    Ly75 is a protein coding gene that encodes Lymphocyte antigen 75. According to some studies, Ly75 may have the following features.
    Lymphocyte antigen 75 (Ly75/CD205) is a surface marker of mitotic germ cells in rainbow trout. Genetic identification Ly75 is a new quantitative trait gene for mice to resist obesity. Systematic multi-omics analysis of Ly75 gene expression and its prognostic value for skin melanoma through natural killer (NK) cell infiltration. Interleukin-6 receptor enhances the early colonization of mouse omentum by up-regulating the mannose family receptor LY75 in ovarian tumor cells. MEN1309 is a novel antibody-drug conjugate (ADC) against Ly75 antigen, which induces a complete response in xenotransplantation of several solid tumors.

  • Datasheet & COA：
    Please contact us to get it.

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Ly75 antibodies

Ly75 Proteins

靶点详情

  • 功能：
    Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes.
  • 基因功能参考文献：
    1. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells PMID: 27041637
    2. DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity PMID: 25819746
    3. The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1. PMID: 24021877
    4. Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection. PMID: 23300927
    5. Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo. PMID: 23297227
    6. Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface. PMID: 22841832
    7. CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo PMID: 22736794
    8. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation. PMID: 22291181
    9. For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. PMID: 21262813
    11. show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag. PMID: 19830741
    12. Results suggest that DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after dendritic cell maturation. PMID: 12486105
    13. This protein was detected in mouse Langerhans cells on epidermis separated by microwave irradiation. PMID: 12503727
    14. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses PMID: 17142738
    15. murine DEC-205 is a receptor for PLA of Yersinia pestis PMID: 18650418
    16. CD205 acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance. PMID: 19135256

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in dendritic and thymic epithelial cells and lymph nodes.
  • 数据库链接：

    KEGG: mmu:17076

    STRING: 10090.ENSMUSP00000028362

    UniGene: Mm.2074

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