KNG1
激肽原（Kininogen-1，简称KNG1）是人体血浆中重要的多功能糖蛋白，其高分子量形式（HMWK）和低分子量形式（LMWK）分别参与不同生理过程。该蛋白在传统研究中被称为Fitzgerald因子或接触激活辅因子，是激肽系统核心成员之一。其通过释放缓激肽等活性肽段，协调血管张力调节、凝血平衡和炎症反应，尤其在血管内皮保护与损伤修复中具有双向调节特性。
激肽原水平异常与遗传性血管水肿、血栓性疾病及高血压密切相关。在动脉粥样硬化进程中，该蛋白既能通过抗凝作用抑制血栓形成，又会因过度激活补体系统加重炎症反应，这种矛盾特性使其成为治疗靶点研究的焦点。目前针对缓激肽受体的抑制剂（如艾替班特）已用于遗传性血管水肿急性发作治疗，而基于激肽原结构设计的抗血栓药物正处于临床前研究阶段。近期有学者探索其修饰产物在肿瘤微环境调控中的应用，为癌症治疗提供了新思路。
热销产品
Recombinant Human Kininogen-1 (KNG1), partial (CSB-EP012479HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KNG1 Antibody (CSB-PA14647A0Rb)
验证数据
Western blot
All lanes: KNG1 antibody at 2µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 48, 44 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA14647A0Rb at dilution of 1:50
Immunofluorescent analysis of HepG2 cells using CSB-PA14647A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Kininogen-1(KNG1) ELISA kit (CSB-EL012479HU)
验证数据
货号：CSB-EL012479HU
规格：96T/48T
灵敏度：11.75 ng/mL
检测范围：47 ng/mL-3000 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
KNG1 Antibodies
KNG1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA14647B0Rb | KNG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA14647D0Rb | KNG1 Antibody, Biotin conjugated | Human | ELISA, IHC |
| CSB-PA012479GA01HU | KNG1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA14647A0Rb | KNG1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA009655 | Cleaved-KNG1 (K380) Antibody | Human | WB, ELISA |
KNG1 for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA012479LA01RA | Kng1 Antibody | Rat | ELISA |
KNG1 Proteins
KNG1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012479HU CSB-EP012479HU CSB-BP012479HU CSB-MP012479HU CSB-EP012479HU-B |
Recombinant Human Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012479HU | Recombinant Human Kininogen-1 (KNG1), partial | E.coli |
KNG1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012479BO CSB-EP012479BO CSB-BP012479BO CSB-MP012479BO CSB-EP012479BO-B |
Recombinant Bovine Kininogen-1 (KNG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012479RA | Recombinant Rat Kininogen-1 (Kng1), partial | Yeast |
| CSB-EP012479RA CSB-BP012479RA CSB-MP012479RA CSB-EP012479RA-B |
Recombinant Rat Kininogen-1 (Kng1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012479MO CSB-EP012479MO CSB-BP012479MO CSB-MP012479MO CSB-EP012479MO-B |
Recombinant Mouse Kininogen-1 (Kng1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KNG1 ELISA Kit
KNG1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL012479HU | Human Kininogen-1(KNG1) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 11.75 ng/mL |
KNG1 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E12725r | Rat kininogen(KNG) ELISA Kit |
