Rat kininogen(KNG) ELISA Kit

产品详情

产品描述：

大鼠激肽原(KNG)酶联免疫试剂盒（CSB-E12725r）为双抗夹心法ELISA试剂盒，定量检测样本中的KNG1含量。KNG1 即激肽原 1，是血浆中产生激肽的前体蛋白。它是多种蛋白水解酶的作用底物，在缓激肽生成、凝血启动等生理过程中发挥重要作用。对 KNG1 的研究有助于深入了解相关疾病发病机制，并为开发新的治疗靶点和药物提供思路。该产品适用于大鼠生物样本中KNG蛋白表达的科研检测，可支持高血压病理模型构建、炎症信号通路解析、药物干预效应评估等基础研究，为探索激肽系统在生理及疾病中的分子机制提供高效工具本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

Kng1 ELISA Kit; Kng ELISA Kit; Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain] ELISA Kit
缩写：

KNG1
Uniprot No.：

P08934
种属：

Rattus norvegicus (Rat)
样本类型：
检测范围：
灵敏度：
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Cardiovascular
测定原理：

quantitative
测定方法：

Sandwich
数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

功能：

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
基因功能参考文献：
1. High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury. PMID: 17293494
亚细胞定位：

Secreted, extracellular space.
组织特异性：

Plasma.
数据库链接：

KEGG: rno:25087

STRING: 10116.ENSRNOP00000065146

UniGene: Rn.128333