HKDC1
HKDC1，即含己糖激酶结构域1，别名RP92。HKDC1由人类HKDC1基因编码，该基因位于10号染色体的q22.1区域。HKDC1编码的蛋白质属于己糖激酶蛋白家族，参与葡萄糖代谢。HKDC1的作用机制涉及其在葡萄糖代谢中的活性，尽管其葡萄糖磷酸化活性相对较低，但它可能具有除了典型己糖激酶活性之外的“兼职”功能。HKDC1的表达减少可能与妊娠糖尿病有关，而其高表达可能与肝癌的不良预后相关。HKDC1在某些癌症中的异常表达与患者总体生存密切相关，表明其可能在癌症进展中发挥作用。HKDC1还可能通过与细胞骨架的耦合激活STAT1并增强PD-L1表达，从而促进肿瘤免疫逃逸。HKDC1被认为是癌症治疗的潜在靶点，尤其是在肝癌和肺癌的治疗中。
热销产品
HKDC1 Antibody (CSB-PA647983LA01HU)
验证数据
Western blot
All lanes: HKDC1 antibody at 4µg/ml + U87 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 103, 91, 83 kDa
Observed band size: 103 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA647983LA01HU at dilution of 1:100
HKDC1 Antibodies
HKDC1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA647983LA01HU | HKDC1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA647983LB01HU | HKDC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA647983LC01HU | HKDC1 Antibody, FITC conjugated | Human | |
| CSB-PA647983LD01HU | HKDC1 Antibody, Biotin conjugated | Human | ELISA |
HKDC1 Proteins
HKDC1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP647983HU CSB-EP647983HU CSB-BP647983HU CSB-MP647983HU CSB-EP647983HU-B |
Recombinant Human Hexokinase HKDC1 (HKDC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HKDC1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP852780MO CSB-EP852780MO CSB-BP852780MO CSB-MP852780MO CSB-EP852780MO-B |
Recombinant Mouse Putative hexokinase HKDC1 (Hkdc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
