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  4. Recombinant Human Hexokinase HKDC1 (HKDC1), partial

Recombinant Human Hexokinase HKDC1 (HKDC1), partial

  • 中文名称：
    人HKDC1重组蛋白
  • 货号：
    CSB-YP647983HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HKDC1重组蛋白
  • 货号：
    CSB-EP647983HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HKDC1重组蛋白
  • 货号：
    CSB-EP647983HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HKDC1重组蛋白
  • 货号：
    CSB-BP647983HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HKDC1重组蛋白
  • 货号：
    CSB-MP647983HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HKDC1
  • Uniprot No.：
    Q2TB90
  • 别名：
    BC016235; Hexokinase domain containing 1; Hexokinase domain-containing protein 1; Hkdc1; HKDC1_HUMAN; Putative hexokinase HKDC1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

HKDC1 antibodies

靶点详情

  • 功能：
    Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role.
  • 基因功能参考文献：
    1. results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
    2. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
    3. Association of HKDC1 genetic variants with susceptibility to gestational diabetes mellitus. PMID: 27346736
    4. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. PMID: 23903356
  • 亚细胞定位：
    Mitochondrion membrane; Peripheral membrane protein.
  • 蛋白家族：
    Hexokinase family
  • 组织特异性：
    Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein lev
  • 数据库链接：

    HGNC: 23302

    KEGG: hsa:80201

    STRING: 9606.ENSP00000346643

    UniGene: Hs.522988

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