CTSB

组织蛋白酶B（Cathepsin B）是一种溶酶体半胱氨酸蛋白酶，常被简称为CathB或CTSB。这种酶在正常生理状态下负责降解受损蛋白质，维持细胞稳态，但在病理条件下可能促进肿瘤侵袭与炎症反应。研究发现，其过度激活会破坏细胞外基质，加速癌细胞穿透血管壁形成转移灶，在乳腺癌、胶质瘤等多种恶性肿瘤中呈现高表达特征。此外，该蛋白酶还参与阿尔茨海默病的β淀粉样蛋白沉积过程，并能激活炎症小体加重类风湿性关节炎。

近年来针对CTSB的药物开发聚焦于特异性抑制剂，例如CA-074系列化合物已显示出阻断肿瘤转移的潜力。部分研究尝试将CTSB抑制剂与免疫检查点疗法联用，通过调控肿瘤微环境增强抗PD-1治疗效果。在神经退行性疾病领域，小分子抑制剂Esteya表现出抑制tau蛋白异常磷酸化的作用，目前处于临床前研究阶段。值得注意的是，新冠病毒感染研究中发现CTSB可能参与病毒刺突蛋白的切割激活，这为抗病毒药物研发提供了新思路。

热销产品

Recombinant Human Cathepsin B (CTSB), partial (CSB-EP006185HU1e1)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTSB Antibody (CSB-PA06974A0Rb)

验证数据

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06974A0Rb at dilution of 1:100

Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue
All lanes: CTSB antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA06974A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA06974A0Rb at dilution of 1:100

Immunofluorescent analysis of A375 cells using CSB-PA06974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human cathepsin B (CTSB) ELISA kit (CSB-E13450h)

验证数据

货号：CSB-E13450h

规格：96T/48T

灵敏度：0.078 ng/mL

检测范围：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CTSB Antibody

CTSB Protein

CTSB ELISA Kit

CTSB Antibodies

CTSB for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA06974A0Rb	CTSB Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA06974B0Rb	CTSB Antibody, HRP conjugated	Human	ELISA
CSB-PA06974C0Rb	CTSB Antibody, FITC conjugated	Human
CSB-PA06974D0Rb	CTSB Antibody, Biotin conjugated	Human	ELISA
CSB-PA006185GA01HU	CTSB Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA001296	CTSB Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA047604	CTSB Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA825136	CTSB Antibody	Human,Mouse,Rat	ELISA,IHC

CTSB Proteins

CTSB Proteins for Ovis aries (Sheep)

产品货号	产品名称	来源
CSB-YP006185SH CSB-EP006185SH CSB-BP006185SH CSB-MP006185SH CSB-EP006185SH-B	Recombinant Sheep Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP006185MO CSB-EP006185MO CSB-BP006185MO CSB-MP006185MO CSB-EP006185MO-B	Recombinant Mouse Cathepsin B (Ctsb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP006185CH CSB-EP006185CH CSB-BP006185CH CSB-MP006185CH CSB-EP006185CH-B	Recombinant Chicken Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP006185RA CSB-EP006185RA CSB-BP006185RA CSB-MP006185RA CSB-EP006185RA-B	Recombinant Rat Cathepsin B (Ctsb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-EP006185HU CSB-BP006185HU CSB-MP006185HU CSB-EP006185HU-B	Recombinant Human Cathepsin B (CTSB)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006185HU1	Recombinant Human Cathepsin B (CTSB), partial	E.coli
CSB-AP005381HU	Recombinant Human Cathepsin B (CTSB), partial (Active)	Mammalian cell
CSB-EP006185HU1e1	Recombinant Human Cathepsin B (CTSB), partial	E.coli
CSB-YP006185HU	Recombinant Human Cathepsin B (CTSB)	Yeast
CSB-MP006185HU3(M)	Recombinant Human Cathepsin B (CTSB)(L26V)	Mammalian cell

CTSB Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP006185BO CSB-EP006185BO CSB-BP006185BO CSB-MP006185BO CSB-EP006185BO-B	Recombinant Bovine Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Sus scrofa (Pig)

产品货号	产品名称	来源
CSB-YP006185PI CSB-EP006185PI CSB-BP006185PI CSB-MP006185PI CSB-EP006185PI-B	Recombinant Pig Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

产品货号	产品名称	来源
CSB-YP006185DXJ CSB-EP006185DXJ CSB-BP006185DXJ CSB-MP006185DXJ CSB-EP006185DXJ-B	Recombinant Coturnix coturnix japonica Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Dictyostelium discoideum (Slime mold)

产品货号	产品名称	来源
CSB-YP006185DKK CSB-EP006185DKK CSB-BP006185DKK CSB-MP006185DKK CSB-EP006185DKK-B	Recombinant Dictyostelium discoideum Cathepsin B (ctsB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Pongo abelii (Sumatran orangutan)

产品货号	产品名称	来源
CSB-YP006185PYX CSB-EP006185PYX CSB-BP006185PYX CSB-MP006185PYX CSB-EP006185PYX-B	Recombinant Pongo abelii Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

产品货号	产品名称	来源
CSB-YP006185MOV CSB-EP006185MOV CSB-BP006185MOV CSB-MP006185MOV CSB-EP006185MOV-B	Recombinant Macaca fascicularis Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli