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  4. Recombinant Rat Solute carrier family 22 member 2 (Slc22a2), partial

Recombinant Rat Solute carrier family 22 member 2 (Slc22a2), partial

  • 中文名称：
    大鼠Slc22a2重组蛋白
  • 货号：
    CSB-YP879498RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc22a2重组蛋白
  • 货号：
    CSB-EP879498RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc22a2重组蛋白
  • 货号：
    CSB-EP879498RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc22a2重组蛋白
  • 货号：
    CSB-BP879498RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc22a2重组蛋白
  • 货号：
    CSB-MP879498RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a2
  • Uniprot No.：
    Q9R0W2
  • 别名：
    Slc22a2; Oct2; Solute carrier family 22 member 2; Organic cation transporter 2; rOCT2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, serotonin, choline, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP and amiloride. Mediates the influx of adrenaline, noradrenaline (norepinephrine), dopamine, cimetidine, famotidine, metformin, N-1-methylnicotinamide (NMN), 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), oxaliplatin and cisplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
  • 基因功能参考文献：
    1. These results provide the first identification of a high affinity neuronal transporter for p-tyramine, and also confirm the recently described localization of OCT2 in pre-synaptic terminals. PMID: 27901065
    2. Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney. PMID: 28414026
    3. Renal rOCT2 levels, but not rOCT1 and rMATE1, were significantly lowered in female rats. PMID: 25876759
    4. A significant age-related decrease in rOCT2 protein expression was observed. PMID: 24981592
    5. cisplatin uptake was increased by OCT2 overexpression in male, but not female rats and associated with increased cellular sensitivity to cisplatin toxicity PMID: 26174463
    6. Data show that lycopene upregulated the organic anion transporters (OAT1 and OAT3) and organic cation transporters (OCT1 and OCT2) in cisplatin-induced acute renal injury. PMID: 24531880
    7. liver I/R decreases the tubular secretion of cimetidine, mainly because of the decreased rOCT2 level in the kidney, and that oxidative stress should be responsible in part for decreased renal rOCT2 after liver I/R injury. PMID: 23774469
    8. we demonstrate that OCT2 (SLC22A2) is expressed in cholinergic neurons, motoneurons in the anterior horn of the spinal cord PMID: 23958595
    9. Protein and mRNA expression levels of Oat1, Oat3, Oct1, and Oct2 were significantly decreased in adenine-induced chronic renal failure rats. PMID: 23280877
    10. renal mRNA level of the organic cation transporter-2 showed an age-related increase; the increase in creatinine clearance highly contributed to the age-related increase in urinary creatinine excretion compared to mRNA levels of Oct2 and Mate1 PMID: 23182769
    11. These observations suggest that the induction of experimental acute renal failure leads to an accumulation of endogenous organic cation(s), probably rOCT2 substrate(s), in the plasma PMID: 22941487
    12. a decrease in urinary creatinine excretion in acute kidney injury was accompanied by a reduction in creatinine clearance and reduced mRNA expression of the renal organic cation transporter-2, which is known to function as a transporter for creatinine PMID: 22005293
    13. OAT3 and OCT2 are expressed at significant levels in the rat olfactory epithelia. PMID: 20924140
    14. the elevated tubular secretion of cimetidine is attributable mostly to the increased expression levels of rOCT2. PMID: 20814153
    15. results suggest that hypomagnesemia could cause dehydration and up-regulation of rOCT2, enhancing renal accumulation of CDDP and the deterioration of AKI. PMID: 19629622
    16. experimental diabetes decreased expression of both rOCT1 and rOCT2 protein and also of roct2 mRNA accumulation. PMID: 14718608
    17. aspartate at position 475 of rOCT2 plays a critical role in transport function PMID: 15016452
    18. adenovirus produced an increase in OCT-2 levels along with increased cellular OCT-2 steady-state mRNA in alveolar type II cells; results indicate that adenoviruses can disrupt choline trafficking in lung epithelia by upregulating expression of OCT-2 PMID: 15377492
    19. analysis of cation binding and permeation in the rat organic cation transporter rOCT2 PMID: 15878879
    20. testosterone induces the expression of rOCT2, but not of rOCT1 and rOCT3, via the androgen receptor-mediated transcriptional pathway PMID: 16550473
    21. Effects of the sulfhydryl reagent methylmethanethiosulfonate (MMTS) on functions of organic cation transporters (OCTs) were investigated. PMID: 17567940
    22. The saturable components involved in the renal uptake of TEA, cimetidine and metformin are mediated mainly by rOct2. PMID: 18230276
    23. During endotoxemia NO, produced by iNOS, is responsible for a down-regulation of the renal influx carriers, Oct1 and Oct2. PMID: 18313662
    24. Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: effects on distribution of a model organic cation, tetraethylammonium. PMID: 18484100
    25. Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine. PMID: 19211691
    26. Inhibition of calmodulin by calmidazolium significantly decreased rOCT2 activity (-49.0 +/- 13.6%, n = 4) in male but not female (9.0 +/- 13.0%, n = 4) rats. PMID: 19330287

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed in the kidney; in the proximal tubule of the outer medulla. Expression is greater in the kidney of male than of female.
  • 数据库链接：

    KEGG: rno:29503

    STRING: 10116.ENSRNOP00000023116

    UniGene: Rn.10555

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