Recombinant Rat Sodium/hydrogen exchanger 3 (Slc9a3), partial

1. In spontaneously hypertensive rats, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated the hypertension caused by the high plasma level of ANG II. PMID: 28490531
2. Results show that renal afferents leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. When renorenal reflex is induced, NHE3 exchanger activity appears to be decreased, resulting in decreased sodium and water reabsorption in the contralateral kidney. PMID: 28126464
3. Reduction of intestinal sodium absorption by selective NHE3 inhibition in the gut lowered high blood pressure and reduced LV remodeling without deteriorating renal functional and structural parameters in obese spontaneously hypertensive rats. PMID: 26727380
4. Increased pendrin in pregnant rats may compensate for the decreased NCC and aid in the renal sodium chloride reabsorption of pregnancy. PMID: 26260990
5. a potential link between NHE3 and Na(+) /K(+) -ATPase in the pathophysiological changes in renal protein handling observed in obesity PMID: 26173747
6. In hypertensive rats, the plasma and tissue renin angiotensin systems are activated, increased Ang II stimulates the expression of NHE3 and SGK1. PMID: 25119059
7. NHE3-mediated proximal tubular sodium reabsorption induced by renal nerve stimulation occurs via intrarenal renin angiotensin system activation and triggering of the AT1 receptor/inhibitory G-protein signaling pathway. PMID: 25656367
8. local changes in pH reduce NHE3 activity, which may explain the pressure natriuresis response to NHE3 redistribution PMID: 25298526
9. these results support the idea that the lower NHE3 transport activity and higher phosphorylation occurring after the development of hypertension are due, at least in part, to reduced PP1-mediated dephosphorylation of NHE3 at serine 552. PMID: 24666699
10. Immunofluorescence experiments showed that NHE3 colocalizes with SGLT2 but not SGLT1 in the renal proximal tubule. Glucose exerts a bimodal effect on NHE3. PMID: 24652792
11. noradrenaline released from renal sympathetic nerve endings activates alpha1-adrenoceptors expressed on proximal tubular epithelial cells, increasing the abundance of NHE3 in the apical brush border membranes to enhance sodium and water reabsorption. PMID: 24118769
12. results indicate that central NHE3 might be a molecular target for sleep apnea treatment, whose inhibitors may be potential therapeutic drugs for sleep apnea. PMID: 24384423
13. There was a significant decrease in the levels of NHE-3 and NHERF-1 proteins, and sodium pump activity, but an increase in the cyclic GMP kinase II levels in spontaneously hypertensive rats. PMID: 23402556
14. NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 PMID: 23612977
15. transferable factor(s) mediate the ischemia-reperfusion injury-induced decrease in NHE3 of the kidney. PMID: 21814178
16. Report NHE3 up-regulation in the solitary kidney in response to partial ureteral obstruction in neonatal rats. PMID: 21677414
17. ANG II stimulates NHE3 via AT1R-PLC-CaM pathway and inhibits NHE3 by AT1R-PKG activation. PMID: 21593187
18. Inhibition of NHE3 expression regulates the expression and function of SGLT1 in the brush border membrane of intestinal epithelial cells. PMID: 21148403
19. sgk2 may play a previously unrecognized role in the control of transtubular Na(+) transport through NHE3 in the proximal tubule. PMID: 20926631
20. IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway. PMID: 20584908
21. Data demonstrate that a calyculin A-sensitive phosphatase, most likely PP1, is involved in the regulation and dephosphorylation of NHE3 at known and novel sites. PMID: 20015946
22. after 20 min ANG II, both NHE3 and NaPi2 redistributed into the microvilli, assayed by confocal microscopy and density gradient fractionation PMID: 19864301
23. the decrease in renal PT Na(+) transport during acute hypertension is mediated by removal of transport-competent NHE3 from the apical brush border to subapical and internal reserves PMID: 11880335
24. proximal kidney tubule NHE3 adapts to chronic metabolic acid-base disorders but not to changes in dietary NaCl intake PMID: 11934693
25. ACTH stimulation of rats causes a selective but reversible suppression of NHE-3 PMID: 11954662
26. c-SRC and ERK play a role in acid-induced activation of NHE-3 protein. PMID: 12081562
27. increased sodium reabsorption might be associated with a shift of NHE3 from an inactive pool to an active pool, thus contributing to sodium retention in a state of proteinuria. PMID: 12191963
28. responses to acute hypertension, including diuresis and redistribution of PT NHE3 into intracellular membranes, require a responsive renin-angiotensin system and may be induced by the increase in NaCl to the macula densa during acute hypertension. PMID: 12372791
29. reduction of renal mass increases mRNA, protein abundance and in vivo activity of NHE-3 along the thick ascending limb of the loop of Henle PMID: 12427137
30. Transcriptional regulation of this rat gene and its functional interactions between GATA-5 and Sp family transcription factors PMID: 12464626
31. Osmolarity of the medium seems to regulate NHE activity in such a manner that both hyper- and hypoosmolar conditions inhibited NHE activity. PMID: 12470201
32. increased abundance of NHE3 and type 1 bumetanide-sensitive cotransporter (BSC-1) in thick ascending limb cells as well as increased NHE3 in the proximal tubule brush border may contribute to enhanced renal Na+ and HCO3 reabsorption in response to ANG II PMID: 12657563
33. renal proximal tubular NHE3 is a target for aldosterone-mediated regulation resulting in increased Na(+) reabsorption and thus extracellular volume and blood pressure. PMID: 12684793
34. NHE3 and NKCC2 protein abundances in kidney are positively regulated by nitric oxide, and the increase in NHE3 abundance seen in aldosterone escape phenomenon is nitric oxide dependent. PMID: 12837683
35. NHE-3 isoform on apical membrane of parietal cells is additional pathway for proton secretion under resting conditions. Gastric NHE-3 works under resting conditions and inactivates during periods of H(+)-K(+)-ATPase activity. PMID: 12907430
36. combined deficiency of corticosterone and thyroxine totally prevents the maturational increase in NHE3 mRNA and protein abundance and Na(+)/H(+) antiporter activity. PMID: 15113742
37. Apical localization of V-ATPase in cholangiocytes may indicate its involvement in pH regulation and/or HCO (3)(-) salvage to compensate for NHE3 down-regulation in BDL. PMID: 16267653
38. NHE3 is a target for nongenomic regulation by aldosterone PMID: 16757729
39. Sodium butyrate induces NHE3 gene transcription by phosphorylation of Sp1/acetylation of Sp3. Binding of Sp3 to the SpB site, would significantly increase NHE3 promoter activity. PMID: 17344314
40. Thyroid hormone plays a potential role in the developmental isoform change from NHE8 to NHE3 and decreases NHE8 activity. PMID: 17977906
41. Inhibition of DPPIV catalytic activity is associated with inhibition of NHE3-mediated NaHCO3 reabsorption in the renal proximal tubule. A physiologically significant interaction exists between NHE3 and DPPIV in the intact proximal tubule in vivo. PMID: 18077600
42. Noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney. PMID: 18177483
43. These results indicate that decreased cNO levels directly mediate the inhibition of SGLT1 and stimulation of NHE3 in intestinal epithelial cells. PMID: 18325982
44. renal steatosis decreases ammonium secretion in the proximal tubule, in part by reducing NHE3 activity and by impairing the regulation of NHE3 by specific agonists PMID: 18417539
45. Bilateral ureteral obstruction caused a significant reduction in the expression of NHE3, NBC1, NKCC2, NBCn1, and pendrin. PMID: 18508879
46. Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. PMID: 19064501
47. Renal NHE3 and NaPi2 partition into distinct membrane domains. PMID: 19158399
48. protein abundance of TRPV5, NHE3, and NKCC2, but not calbindin-D(28K) decreased in all hypercalciuric rats PMID: 19194547
49. Altered renal expression of NHE3 in protein-deprived rats. PMID: 19202345
50. AII induced increases in rat NHE3 gene promoter-reporter activity. PMID: 19338654

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KEGG: rno:24784

STRING: 10116.ENSRNOP00000020711

UniGene: Rn.9706