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  4. Recombinant Rat Keratin, type I cytoskeletal 14 (Krt14)

Recombinant Rat Keratin, type I cytoskeletal 14 (Krt14)

  • 中文名称：
    大鼠Krt14重组蛋白
  • 货号：
    CSB-YP740231RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Krt14重组蛋白
  • 货号：
    CSB-EP740231RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Krt14重组蛋白
  • 货号：
    CSB-EP740231RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Krt14重组蛋白
  • 货号：
    CSB-BP740231RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Krt14重组蛋白
  • 货号：
    CSB-MP740231RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Krt14
  • Uniprot No.：
    Q6IFV1
  • 别名：
    Krt14; Ka14; Krt1-14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14; Type I keratin Ka14
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-485
  • 氨基酸序列
    MATCSRQFTS SSSMKGSCGI GGGSSRMSSV LAGGSCRAPS TYGGMSRFSS AGAYAVGSGY GGGFSSSSFG GGFGGGIGGG IGGGLGGGIG GGFGGGIGGG FGGGIGSGFG GGLGDGLLVG SEKVTMQNLN DRLATYLDKV RALEEANSDL EVKIRDWYQR QRPTEIKDYS PYFKTIEDLK SKILAATVDN ANVLLQIDNA RLAADDFRTK FETEQSLRIN VESDINGLRR VLDELTLARA DLEMQIESLK EELAYLKKNH EEEMASMRGQ VGGDVNVEMD AAPGVDLSRI LNEMRDQYEK MAEKNRKDAE DWFFTKTEEL NREVATNSEL VQSGKSEISE LRRTMQNLEI ELQSQLSMKA SLENNLEETK GRYCMQLAQI QEMIGSVEEQ LAQLRCEMEQ QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLSSAQFSS SSQFSSGSQS SRDVTSTNRQ IRTKVMDVHD GKVVSTHEQV LRTKN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
  • 基因功能参考文献：
    1. These findings strongly suggest that Krt-14 regulates osteoblast mineralization by organizing osteoblast derived ECM. PMID: 26956522
    2. In taste buds, the conversion of cytokeratin subtypes occurred from cytokeratin 14 to cytokeratin 8 at day 2-3, showing the differentiation from immature cells expressing cytokeratin 14 into mature or maturing cells expressing cytokeratin 8. PMID: 17960487
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Expressed in most cells of squamous cell carcinomas, in spinous and suprabasal cells around the branching papillary region of papillomas, and weakly in a few proliferative cells of hyperplastic tissue.
  • 数据库链接：

    KEGG: rno:287701

    STRING: 10116.ENSRNOP00000005285

    UniGene: Rn.145931

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