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  4. Recombinant Rat GDNF family receptor alpha-1 (Gfra1)

Recombinant Rat GDNF family receptor alpha-1 (Gfra1)

  • 中文名称：
    大鼠Gfra1重组蛋白
  • 货号：
    CSB-YP717294RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gfra1重组蛋白
  • 货号：
    CSB-EP717294RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gfra1重组蛋白
  • 货号：
    CSB-EP717294RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gfra1重组蛋白
  • 货号：
    CSB-BP717294RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gfra1重组蛋白
  • 货号：
    CSB-MP717294RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gfra1
  • Uniprot No.：
    Q62997
  • 别名：
    Gfra1; Gdnfra; Retl1; Trnr1GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-430
  • 氨基酸序列
    DRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF SLTSGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRAVPFISD VFQQVEHISK GNNCLDAAKA CNLDDTCKKY RSAYITPCTT SMSNEVCNRR KCHKALRQFF DKVPAKHSYG MLFCSCRDIA CTERRRQTIV PVCSYEERER PNCLSLQDSC KTNYICRSRL ADFFTNCQPE SRSVSNCLKE NYADCLLAYS GLIGTVMTPN YVDSSSLSVA PWCDCSNSGN DLEDCLKFLN FFKDNTCLKN AIQAFGNGSD VTMWQPAPPV QTTTATTTTA FRVKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGS THLCLSDSDF GKDGLAGASS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
  • 基因功能参考文献：
    1. Exercise-Mediated Increase in Nigral gfra1 in aging rats. PMID: 26599339
    2. these studies reveal a diverse range of potential targets by which artemin could influence bladder function, nerve regeneration, and pain. PMID: 25043933
    3. Data suggest that a dietary factor (here, docosahexaenoic acid-DHA) can up-regulate the expression of Gfra1 in hippocampal neurons of the natural aged female rat; DHA improves oxidative parameters and activates the Gdnf/Gfra1-MAPK pathway. PMID: 23767459
    4. Expression levels of GDNF and GFRalpha1 proteins increase gradually over time in experimental diabetic retinopathy under high glucose and exogenous GDNF-treated conditions. PMID: 22266674
    5. Post-synaptic striatal glial cell line-derived neurotrophic factor receptor-alpha1 expression effects the biology of dopamine neurons in vivo. PMID: 21133924
    6. we speculate that (i) GFR alpha-1 receptor expression may regulate nigral dopamine bioavailability in vivo PMID: 20731758
    7. these unanticipated results indicate that GFRalpha1b is involved in glioma migration through glial cell line-derived neurotrophic factor -GFRalpha1b-Neural Cell Adhesion Molecule signaling complex and modulation of RhoA expression PMID: 20807316
    8. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
    9. the expression of GDNF receptors mRNA in glial cells play an important role in mediating the process of morphine dependence and may be account for the long-term neuro-adaptation associated with morphine dependence. PMID: 11798749
    10. GFRalpha-1 displays a widespread distribution in the CNS and in neurons with different phenotypes. PMID: 12535958
    11. Structural elements in GFRalpha1 may be involved in binding to GDNF and Ret. PMID: 14563851
    12. Data report the crystal structure of GFRalpha1 domain 3, and the effects of specific mutations on GDNF binding and RET phosphorylation. PMID: 15044950
    13. PSPN/GFRalpha4 is unable to recruit RET into lipid rafts, GFRalpha4 in this respect differs from GFRalpha1 PMID: 15225646
    14. The GFRalpha1 is expressed in striatum maximally late in postnatal development. In this location it may act in trans to influence the viability and development of nigral dopamine neurons. PMID: 15306125
    15. GFRalpha1 receptor splicing variant expression with different biochemical properties is modulated during kidney development PMID: 15381258
    16. Extremely high selectivity of GFR alpha 1 for glial cell line-derived neurotrophic factor (GDNF) over artemin (ART) and the low reactivity of ART for this receptor suggest that GFR alpha 1 is not likely to be a functional coreceptor for ART in vivo. PMID: 15709767
    17. Endogenous GDNF and GFRalpha-1 msy play an anti-hyperalgesic role in neuropathic pain of rats PMID: 16289634
    18. expression of GFRalpha-1 in DRGs was down-regulated by intrathecal delivery of antisense ODN PMID: 16464682
    19. Expression of GDNF receptors in the periodontal mechanoreceptor. PMID: 16513266
    20. Decrease of GFRalpha1 immunoreactivity was significant in varicocele-induced testis. PMID: 17240430
    21. GFRalpha-1 protein levels increase in ipsilateral medial vestibular nucleus (MVN) while mRNA expression levels in ipsi- and contralateral MVN steadily decrease post unilateral labyrinthectomy. PMID: 17538205
    22. Nonpeptidergic afferents expressing GFRalpha1 were largely unaffected by spinal cord injury. PMID: 17640046
    23. GFRalpha1-labeled fibers were in outer lamina II and the lateral-collateral pathway and associated with autonomic interneurons and preganglionic neurons. PMID: 18085594
    24. Integrin beta1 can form a complex with GFRalphal. Simulation molecular modeling showed that 4 H-bonds were formed between integrin beta1 & GFRalpha. PMID: 18465789
    25. analysis of how GDNF.GFR alpha 1 can mediate cell adhesion and how heparin might inhibit GDNF signaling through RET PMID: 18845535

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body.
  • 蛋白家族：
    GDNFR family
  • 组织特异性：
    Expressed in liver, brain, kidney and cochlea.
  • 数据库链接：

    KEGG: rno:25454

    STRING: 10116.ENSRNOP00000023667

    UniGene: Rn.88489

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