GFRA1
GFRα1（胶质细胞源性神经营养因子受体α1）是GDNF家族配体的核心受体之一，通过与RET酪氨酸激酶受体形成复合物调控神经元存活与分化。该蛋白在胚胎发育期对交感神经、肾脏及肠道神经系统的形成起关键作用，其功能异常可能引发先天性巨结肠症、多巴胺能神经元退化等疾病。近年研究发现GFRα1在甲状腺癌、神经母细胞瘤中存在异常表达，其介导的RET信号过度激活与肿瘤侵袭转移密切相关。针对这一通路开发的凡德他尼、卡博替尼等RET抑制剂已获批用于甲状腺髓样癌治疗，而基于GDNF-GFRα1系统的基因疗法在帕金森病动物模型中展现出神经保护潜力。目前重组GDNF蛋白的鞘内给药方案正在进行Ⅱ期临床试验，旨在为肌萎缩侧索硬化等神经退行性疾病提供新治疗策略。
热销产品
GFRA1 Antibody (CSB-PA009379LA01HU)
验证数据
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Mouse kidney tissue
All lanes: GFRA1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 51 kDa
Observed band size: 52 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009379LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA009379LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GFRA1 Antibodies
GFRA1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008804 | GFRA1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA449746 | GFRA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009379LA01HU | GFRA1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA009379LB01HU | GFRA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009379LC01HU | GFRA1 Antibody, FITC conjugated | Human | |
| CSB-PA009379LD01HU | GFRA1 Antibody, Biotin conjugated | Human | ELISA |
GFRA1 Proteins
GFRA1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009379HU CSB-EP009379HU CSB-BP009379HU CSB-MP009379HU CSB-EP009379HU-B |
Recombinant Human GDNF family receptor alpha-1 (GFRA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
