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  4. Recombinant Mouse Wolframin (Wfs1), partial

Recombinant Mouse Wolframin (Wfs1), partial

  • 中文名称：
    小鼠Wfs1重组蛋白
  • 货号：
    CSB-YP026100MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Wfs1重组蛋白
  • 货号：
    CSB-EP026100MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Wfs1重组蛋白
  • 货号：
    CSB-EP026100MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Wfs1重组蛋白
  • 货号：
    CSB-BP026100MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Wfs1重组蛋白
  • 货号：
    CSB-MP026100MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Wfs1
  • Uniprot No.：
    P56695
  • 别名：
    Wfs1Wolframin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism.
  • 基因功能参考文献：
    1. the functional link between Wfs1 and D1-like dopamine receptors is evolutionarily conserved and plays an important role in adjusting behavioral reactions to environmental stimuli. PMID: 28267787
    2. Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis. PMID: 27264872
    3. WFS1-knockout mice develop a metabolic phenotype characterized with several physiological dysfunctions. PMID: 26733243
    4. RNA-sequencing of pancreatic islets from WFS1-deficient mice showed that Trpm5 is downregulated and the pathways related to tissue morphology, and endocrine system development/function/molecular transport network are influenced. PMID: 27053292
    5. Study demonstrates that Wfs1 deficiency in mice induces alterations in specific behavioural effects of ethanol like the increased anxiolytic-like and hypnotic action, but the decreased sedation PMID: 25725334
    6. Na-pump alpha1 -subunit mRNA was significantly decreased in the dorsal striatum and midbrain of Wfs1-deficient homozygous animals compared with wild-type littermates. PMID: 25385034
    7. Results reveal a role for WFS1 in the negative regulation of SERCA and provide further insights into the function of WFS1 in calcium homeostasis. PMID: 25274773
    8. Energy metabolism and thyroid function of mice with deleted wolframin (Wfs1) gene. PMID: 24710642
    9. We show that the expression of Wfs1 starts during late embryonic development in the dorsal striatum and amygdala, then expands broadly at birth, possessing several transitory regions during maturation. PMID: 24694561
    10. Present results indicate that the effects of Wfs1-deficiency on behavioral rhythmicity are subtle suggesting that Wfs1 is not a major player in the neural networks responsible for circadian rhythmicity of behavior. PMID: 22800759
    11. Gene expression profiling was performed in Wfs1-deficient mice. PMID: 22028430
    12. Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene. PMID: 21031341
    13. ER stress induces Smurf1 degradation and WFS1 up-regulation PMID: 21454619
    14. homozygous Wfs1 mutant mice (AUC = 0.212 nM/mul h) show significantly decreased striatal dopamine output in response to high-concentration [K+] challenge as compared with wild-type PMID: 20972658
    15. Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. PMID: 21199859
    16. a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes. PMID: 20160352
    17. Data show that the impaired fertility of Wfs1KO male mice is most likely due to changes in sperm morphology and reduced number of spermatogenic cells. PMID: 19664290
    18. may play a role in inner ear ion homeostasis as maintained by the canalicular reticulum PMID: 12649740
    19. The role of WFS1 in the etiology of Wolfram syndrome is examined in WFS1 mutant mice. PMID: 15056606
    20. Data indicate that endoplasmic reticulum (ER)-stress and N-glycosylation play important roles in WFS1 expression and stability, and also suggest regulatory roles for this protein in ER-stress induced cell death. PMID: 15522226
    21. Wfs1 expression, which is localized to beta- and delta-cells in pancreatic islets, increases in response to endoplasmic reticulum stress, suggesting a functional link between Wfs1 and ER stress PMID: 15994758
    22. WFS1-deficiency activates the ER stress response specifically in beta-cells, causing beta-cell loss through impaired cell cycle progression and increased apoptosis. PMID: 16571599
    23. After cat odor exposure the expression of Wfs1 gene was significantly lower in the mesolimbic area and temporal lobe of Bl6 mice compared to 129Sv strain. PMID: 17884289
    24. Wfs1 knockout mice did not show abnormalities in circadian rhythm and periodic fluctuation of wheel-running activity but had retardation in emotionally triggered behavior, decreased social interaction, and altered behavioral despair PMID: 18343518
    25. Lack of Wfs1 protein function can be related to several neurological and psychiatric symptoms found in Wolfram syndrome. PMID: 18551525
    26. Wfs1 mRNA and protein were widely distributed in normal mouse visual system. This evidence may provide clues as to physiological role of Wfs1 protein in biology of vision and help to explain selective vulnerability of optic nerve to WFS1 loss-of-function. PMID: 18613120
    27. Data show that Wfs1-deficient mice display impaired behavioural adaptation in stressful environment. PMID: 19041897
    28. Wfs1-deficient beta cells are susceptible to endoplasmic reticulum stress; increased insulin causes prompts apoptosis in such cells in vivo. PMID: 19190890
    29. Results suggest that further studies are needed to describe biochemical and molecular changes of the growth hormone axis as well as in other hormones to clarify their role in growth retardation in the Wfs1 mutant. PMID: 19293327
    30. Wfs1 mRNA was widely distributed in the normal mouse brain during postnatal development. PMID: 19428703
    31. The present study demonstrated that increased anxiety of Wfs1-deficient mice is probably linked to reduced expression of Gabra1 and Gabra2 genes in the frontal cortex and temporal lobe. PMID: 19477223

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle.
  • 组织特异性：
    Highly expressed in the developing lens.
  • 数据库链接：

    KEGG: mmu:22393

    STRING: 10090.ENSMUSP00000048053

    UniGene: Mm.20916

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