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  4. Recombinant Mouse Urea transporter 2 (Slc14a2), partial

Recombinant Mouse Urea transporter 2 (Slc14a2), partial

  • 中文名称：
    小鼠Slc14a2重组蛋白
  • 货号：
    CSB-YP837151MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc14a2重组蛋白
  • 货号：
    CSB-EP837151MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc14a2重组蛋白
  • 货号：
    CSB-EP837151MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc14a2重组蛋白
  • 货号：
    CSB-BP837151MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc14a2重组蛋白
  • 货号：
    CSB-MP837151MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc14a2
  • Uniprot No.：
    Q8R4T9
  • 别名：
    Slc14a2; Ut2; Urea transporter 2; Solute carrier family 14 member 2; Urea transporter; kidney
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Vasopressin regulates urea transport by increasing isoform A1 accumulation in the plasma membrane and/or phosphorylation of isoform A1.
  • 基因功能参考文献：
    1. Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs. PMID: 27914708
    2. results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration PMID: 27161213
    3. Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine. PMID: 25298343
    4. It is concluded that NaCl and urea synergistically induce the expression of UTA2 rather than AQP2 in mIMCD3 cells, and hyperosmolality probably mediates the expression of AQP2 and UTA2 through different mechanisms. PMID: 22282246
    5. These results suggest that in wild-type mice UT-A2 facilitates urea absorption by urea efflux from the thin descending limb of short loops of Henle. PMID: 21849488
    6. Levels of UTA mRNA were increased in thirsted mice compared with control animals PMID: 11880324
    7. potassium depletion is associated with reduced expression of UT-A1, UT-A3, and UT-B but increased expression of UT-A2. PMID: 12952854
    8. mUT-A3 is a basolateral membrane transporter expressed in inner medullary collecting duct cells. PMID: 15075194
    9. lack of UT-B does not result in a change in expression of urea transporters involved in urea reabsorption from the inner medullary collecting duct (UT-A1 and UT-A3). PMID: 15100356
    10. UT-A2 is important for maintaining a high concentration of urea in the inner medulla when urea supply to the kidney is limited PMID: 16055743
    11. These results demonstrate that 4.2 kb of the UT-Aalpha promoter is sufficient to drive expression of a heterologous reporter gene in a tissue-specific and cell-specific fashion in transgenic mice. PMID: 16091580
    12. Urea transporter UT-A2 is acutely sensitive to AVP, cAMP, or increased intracellular calcium. PMID: 16449356
    13. data suggest that the Gamble phenomenon is largely a manifestation of facilitated urea transport in the inner medulla collecting dut by UT-A1 and UT-A3 PMID: 16478978
    14. UT-A1 is a target gene of KLF12. PMID: 16615998
    15. results indicate that UT-A3 is acutely regulated by arginine vasopressin, via a protein kinase A-dependent pathway in MDCK type I cells PMID: 17148784
    16. Biophysical characterization of mouse UT-A2 and UT-A3 undertaken by expression in Xenopus laevis oocytes and preparation of plasma membrane vesicles for use in stopped-flow fluorometry. PMID: 18256317
    17. ubiquitination regulates the plasma membrane expression of all three major UT-A urea transporters, but that this is not the mechanism primarily used by vasopressin to produce its physiological effects. PMID: 18448630
    18. Three distinct variations in the appearance of the renal pelvis were found in UT-A1/3(-/-) mice PMID: 18854850
    19. study investigated the vasopressin regulation of the basolateral urea transporter UT-A3 using an MDCK-mUT-A3 cell line; vasopressin significantly increases UT-A3 localization at the basolateral membrane PMID: 19052101

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Urea transporter family
  • 组织特异性：
    Highly expressed in kidney medulla. Also detected at the protein level in testes, heart, brain and liver. In the kidney, present in thin descending limbs of the loop of Henle and in the middle and terminal inner medullary collecting ducts. Isoform A5 is e
  • 数据库链接：

    KEGG: mmu:27411

    STRING: 10090.ENSMUSP00000025434

    UniGene: Mm.44158

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