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  4. Recombinant Mouse UDP-glucose:glycoprotein glucosyltransferase 1 (Uggt1), partial

Recombinant Mouse UDP-glucose:glycoprotein glucosyltransferase 1 (Uggt1), partial

  • 中文名称：
    小鼠Uggt1重组蛋白
  • 货号：
    CSB-YP747409MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Uggt1重组蛋白
  • 货号：
    CSB-EP747409MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Uggt1重组蛋白
  • 货号：
    CSB-EP747409MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Uggt1重组蛋白
  • 货号：
    CSB-BP747409MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Uggt1重组蛋白
  • 货号：
    CSB-MP747409MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Uggt1
  • Uniprot No.：
    Q6P5E4
  • 别名：
    Uggt1; Gt; Ugcgl1; Uggt; Ugt1; UgtrUDP-glucose:glycoprotein glucosyltransferase 1; UGT1; EC 2.4.1.-; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
  • 基因功能参考文献：
    1. Loss of UGT1 expression is associated with neonatal hyperbilirubinemia. PMID: 28025333
    2. Increased UGGT1 levels elevated viral growth rates, while viral pathogenicity was observed to be lower in heterozygous knockout mice (Uggt1 +/- mice). These findings provide important insight on the role of UPR and host UGGT1 in regulating RNA virus replication and pathogenicity. PMID: 28545059
    3. study demonstrates that UGGT1 enzymatic activity, in conjunction with lectin-like chaperones, helps to limit aggregation and polymer formation of misfolded glycoprotein substrates, decreasing their BiP association and ER stress PMID: 23864712
    4. the expression of two UGGT isoforms, UGGT1 and UGGT2 was demonstrated and both isoforms are active mouse hybridoma cells. PMID: 24140206
    5. UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin. PMID: 20498017

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  • 亚细胞定位：
    Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    Glycosyltransferase 8 family
  • 数据库链接：

    KEGG: mmu:320011

    STRING: 10090.ENSMUSP00000037930

    UniGene: Mm.261022

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