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  4. Recombinant Mouse Transcription factor SOX-1(Sox1)

Recombinant Mouse Transcription factor SOX-1(Sox1)

In Stock
  • 中文名称：
    小鼠Sox1重组蛋白
  • 货号：
    CSB-EP022417MO
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Sox1
  • Uniprot No.：
    P53783
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    46.6 kDa
  • 表达区域：
    1-391aa
  • 氨基酸序列
    MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGTKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGIPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Sox1 Proteins

靶点详情

  • 功能：
    Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
  • 基因功能参考文献：
    1. Optimal SOXB1 levels are critical for each pluripotent state and for cell fate decisions during exit from naive pluripotency. PMID: 29256862
    2. These results demonstrate a novel role for SOX2 in glial process outgrowth and adhesion, and provide new insights into the essential role Muller glia play in the development of retinal cytoarchitecture. PMID: 27031842
    3. Sox10 overexpression causes mammary cells to undergo a mesenchymal transition. PMID: 26365194
    4. Sox1 lineage labels activated neural stem/progenitor cells in the adult mouse hippocampus. PMID: 22992951
    5. Data show that a neural crest cells (NCCs) population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin. PMID: 23347447
    6. genes induced in a SoxB1-dependent manner appear to constitute repressive gene regulatory networks that are directly interlinked. PMID: 23589857
    7. Sox1, a member of the SoxB1 family of transcription factors, is expressed in a subset of radial astrocytes PMID: 22992951
    8. Sox1 regulates the size of the cortical neural progenitor pool via suppression of neurogenic cell divisions. PMID: 21280160
    9. Genetic fate mapping and loss-of-function analysis show that transcription factor Sox1 is expressed in, and required for, a third type of p2-derived interneuron, which has been named V2c. PMID: 20844123
    10. Our results show that the Bergmann glia population expresses Sox1 during cerebellar development, and that these cells can be isolated and show stem cell characteristics in vitro, suggesting that they could hold a broader potential than previously thought. PMID: 19823196
    11. These data integrate functional roles of neural patterning factors, Notch signalling and SOX1 during gliogenesis. PMID: 19723505
    12. SOX1 is essential for ventral telencephalic development PMID: 12770556
    13. newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens, although they are separated by the entire HSPB2 gene PMID: 15113840
    14. Ventral striatum precursors and their early neuronal differentiation are unaffected in the absence of SOX1, but the prospective neurons fail to migrate to their appropriate position. PMID: 15882093
    15. Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment PMID: 17719572
    16. expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells PMID: 18522499
    17. Sox1 enhances neuroectodermal commitment and maintenance but blocks further differentiation. In contrast, Pax6 is involved in the progression of neuroectoderm toward radial glia. PMID: 18832594

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly in the developing central nervous system. Expressed in developing urogenital ridge.
  • 数据库链接：

    KEGG: mmu:20664

    STRING: 10090.ENSMUSP00000137203

    UniGene: Mm.39088

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