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  4. Recombinant Mouse Progesterone receptor (Pgr), partial

Recombinant Mouse Progesterone receptor (Pgr), partial

  • 中文名称：
    小鼠Pgr重组蛋白
  • 货号：
    CSB-YP017875MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pgr重组蛋白
  • 货号：
    CSB-EP017875MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pgr重组蛋白
  • 货号：
    CSB-EP017875MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pgr重组蛋白
  • 货号：
    CSB-BP017875MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pgr重组蛋白
  • 货号：
    CSB-MP017875MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pgr
  • Uniprot No.：
    Q00175
  • 别名：
    Pgr; Nr3c3; Pr; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
  • 基因功能参考文献：
    1. Downregulation of the PGRA isoform at the window of receptivity is necessary to produce a receptive environment for the attaching embryo. PMID: 28203817
    2. PR inactivation in early osteoprogenitor cells but not in mature osteoblasts influenced trabecular bone accrual in a sex-dependent manner. PR deletion in osteoblast lineage cells did not affect cortical bone mass. PMID: 28569405
    3. Our results identified PIK3IP1 as a novel target of ARID1A and PGR in the murine uterus. PMID: 29289536
    4. Glandular epithelial androgen receptor (AR) inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor expression in the uterus. PMID: 26984887
    5. Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes. PMID: 27910070
    6. loss of PGR impairs kisspeptin secretory machinery and therefore that PGR plays a critical role in regulating kisspeptin secretion. PMID: 27441639
    7. PR isoforms are differentially regulated by estradiol and that the induction of PR-B expression is associated to specific transcription factors interactions and epigenetic changes in its promoter in embryonic hypothalamic cells. PMID: 26676302
    8. The results show that mPges-1 may be a direct downstream target gene of the progesterone receptor. PMID: 27174800
    9. Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation. PMID: 27080304
    10. Calvarial cells had more potential to differentiate into osteoblasts and displayed more osteogeic markers after the PR expression was ablated from the Mx1+ cells. This indicates that PRs may play a role in the later stages of osteoblast differentiation. PMID: 26431032
    11. The effects of dexamethasone on uterine epithelial proliferation occur partially through non-progesterone mechanisms, but also through progesterone receptors. PMID: 25882702
    12. progesterone receptor is a key contributor to the hypoxic ventilatory response in newborn mice PMID: 25172890
    13. Progesterone/estrogen receptors are expressed in different epithelial populations, and target non-overlapping pathways in the normal human breast. In breast cancer, PR becomes highly correlated with ER. PMID: 25261374
    14. Progesterone receptor rapid and nonclassical transcriptional effects govern breast cancer growth. PMID: 24345432
    15. PgR expression may play an important role in the maturation of cortical connectivity and sensorimotor PMID: 23983142
    16. RANKL is a direct progesterone receptor (PR) target gene and Stat5a has a novel role as a cofactor in PR-mediated transcriptional signaling in the mammary gland. PMID: 24014651
    17. Study shows that PR is able to selectively target the endometrial vasculature in a coordinated and sustained permeability response. PMID: 24485460
    18. The molecular mediators of proesterone receptor-dependent ductal side-branching overlap with those implicated in breast cancer. PMID: 23979845
    19. Progesterone receptor function may be involved in the development of diabetes mellitus. PMID: 23827354
    20. Progesterone receptor A stability is mediated by glycogen synthase kinase-3beta in the Brca1-deficient mammary gland. PMID: 23880761
    21. This study demonstrates PR-mediated dynamic expression of Npl in the periimplantation uterus and dispensable role of Npl in uterine function and embryo development. PMID: 23741500
    22. Data from transgenic mice suggest that balance between isoforms of Pgr is critical for mammary tissue homeostasis; PgrA overexpression leads to increased side branching/multilayered ducts; PgrB overexpression leads to limited ductal growth. [REVIEW] PMID: 23810007
    23. Overexpression of progesterone receptor expression is associated with mammary carcinoma. PMID: 23867473
    24. Data indicate that STAT3 physically interacted with progesterone receptor (PR)-A, which is known to be important for uterine development and function, but not with PR-B. PMID: 23531596
    25. A mechanism by which steroid hormones can produce the expansion of steroid hormone receptor-negative mammary epithelial cells. PMID: 23462470
    26. The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. PMID: 23307939
    27. study demonstrates that, unlike the effects on Esr1, folate deficiency in mice does not influence the methylation and expression of Pgr and Cdh1 PMID: 22706342
    28. Sox17 represents a potentially novel mediator of progesterone receptor action in the murine uterus. PMID: 22638070
    29. Data suggest an important role of miR-200a in the decline in progesterone receptor (PR) function leading to labor. PMID: 22529366
    30. Activation of ESR1 resulted in: pituitary Pgr expression (35.9+/-2.0% of pituitary cells). PMID: 22367588
    31. Data show that female Wnt7a-Cre(+)PR(f/-) mice are infertile due to defects in embryo attachment, stromal cell decidualization, and the inability to cease estrogen-induced epithelial cell proliferation. PMID: 22155565
    32. does not contribute to the growth or degradation of the extracellular matrix or proinflammatory processes associated with recruitment of macrophages in the cervix leading up to birth PMID: 21613631
    33. upregulation of Brca1 may be required for prepubertal dietary genistein exposure to reduce later mammary tumorigenesis; in the absence of this upregulation, mice do not exhibit genistein-induced downregulation of ER-alpha, PgR, and Rankl PMID: 21680703
    34. Decreased progesterone receptor activity contributes to depression-like behavior in mice. PMID: 21163582
    35. Progesterone receptor directly inhibits beta-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications PMID: 21527503
    36. in constitutive antiprogestin-resistant tumors, Progesteron Receptor A expression was silenced by DNA methylation PMID: 20440553
    37. Developmental exposure of either parent to TCDD is associated with preterm birth in a subsequent adult pregnancy due to altered PR expression and placental inflammation. PMID: 21093581
    38. FGFR-2, STAT5, and progesterone receptors have roles in breast cancer PMID: 21464042
    39. An active role of continued PR expression in the luminal epithelium for the initial implantation process. PMID: 21371703
    40. a novel role of PRs as crucial mediators in the development of epileptogenesis. PMID: 21228174
    41. E3-ligase activity rather than the coactivation function of E6-AP plays an important role in the mammary gland development, and the ubiquitin-dependent PR-B degradation is not required for its transactivation functions. PMID: 20829392
    42. RANKL represents a critical mediator of mammary progesterone receptor action and that restricted expression of this effector to the ER(+)/PR(+) mammary cell-type is necessary for a spatially ordered morphogenetic response to progesterone PMID: 20605949
    43. identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear translocation and the assembly of a transcriptional complex in which ErbB-2 acts as a coactivator of Stat3 PMID: 20876300
    44. Findings suggest a crucial role for progesterone signaling in bone acquisition and inhibition of the nuclear progesterone receptor as a novel approach to augment bone mass, which may have the potential to reduce the burden of osteoporosis. PMID: 20625385
    45. described the localization of ERa, ERb, and PR in the mouse hippocampus and identified a novel fluctuation of hippocampal extranuclear ER and PR expression across the estrous cycle that may participate in cyclic changes in hippocampal function. PMID: 20506473
    46. The HER4 intracellular domain is a physiologically important ERalpha coactivator and cooperates with ERalpha to potentiate PgR expression in the normal and malignant breast. PMID: 20550710
    47. Cyclin D1's participation in a feed-forward loop could contribute to increased breast cancer risks associated with estrogen and progesterone combinations. PMID: 20404095
    48. Data show that D-homoandrostadiene derivatives 2-4 are antagonists of the progesterone receptors. PMID: 19913568
    49. effect of GnRH-I on gsu alpha expression mediated by ligand-independent activation of progesterone receptor PMID: 20051488
    50. Findings show the presence and hormonal regulation of two distinct mPRs associated with the cilia of the fallopian tubes in both mice and women. PMID: 19715581

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 组织特异性：
    Expression of isoform A and isoform B in mammary epithelial cells is temporally and spatially separated during normal mammary gland development. Isoform A and isoform B are expressed in the pituitary. Isoform A and isoform B are differentially expressed i
  • 数据库链接：

    KEGG: mmu:18667

    STRING: 10090.ENSMUSP00000063562

    UniGene: Mm.12798

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