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  4. Recombinant Mouse Plectin (Plec), partial

Recombinant Mouse Plectin (Plec), partial

  • 中文名称：
    小鼠Plec重组蛋白
  • 货号：
    CSB-YP868769MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Plec重组蛋白
  • 货号：
    CSB-EP868769MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Plec重组蛋白
  • 货号：
    CSB-EP868769MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Plec重组蛋白
  • 货号：
    CSB-BP868769MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Plec重组蛋白
  • 货号：
    CSB-MP868769MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plec
  • Uniprot No.：
    Q9QXS1
  • 别名：
    Plec; Plec1; Plectin; PCN; PLTN; Plectin-1; Plectin-6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
  • 基因功能参考文献：
    1. data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation. PMID: 26527396
    2. Data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice. PMID: 25971800
    3. results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways. PMID: 26019234
    4. Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin beta 4 disrupts the complex, resulting in disassembly of hemidesmosomes. PMID: 25703379
    5. Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner. PMID: 25318670
    6. the lack of plectin has divergent implications on biomechanical properties depending on the respective cell type. PMID: 25447312
    7. Ablation of plectin in myelinating Schwann cells is found not to affect myelin sheath formation. PMID: 23836526
    8. Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells. PMID: 23761073
    9. findings suggest a mechanism for microtubule(MT)destabilization in which isoform-specific binding of P1c to MTs antagonizes the MT-stabilizing and assembly-promoting function of MT-associated proteins through an inhibitory function exerted by plectin's SH3 domain PMID: 23363598
    10. plectin 1a, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that degradation of hemidesmosome-anchored plectin is spatially controlled. PMID: 22144912
    11. two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages PMID: 21665277
    12. Mature focal adhesions and their derivative fibronectin fibril-aligned fibrillar adhesions (FbAs) serve as docking sites for vimentin intermediate filaments (IFs) in a plectin isoform 1f (P1f)-dependent manner. PMID: 20702585
    13. BPAG1-b was detectable in vitro and in vivo as a high molecular mass protein in striated and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin. PMID: 19932097
    14. plectin binds to Fer kinase PMID: 12200133
    15. Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes PMID: 12542521
    16. dermal fibroblasts isolated from plectin 1-deficient mice exhibited abnormalities in their actin cytoskeleton PMID: 16344482
    17. Here we present data on the expression of plectin rodless isoforms in mouse brain and in rat glioma C6 cells on RNA and protein levels. PMID: 16392042
    18. Data show that, in differentiated mouse myotubes, plectin binds to the regulatory gamma1 subunit of AMP-activated protein kinase (AMPK), the key regulatory enzyme of energy homeostasis. PMID: 16608880
    19. These data establish a link between cytolinker-controlled cytoarchitecture/scaffolding functions of keratin IFs and specific MAP kinase cascades mediating distinct cellular responses. PMID: 16908671
    20. endogenous plectin is nitrosylated in vivo, NO donor-induced intermediate filament collapse proceeds faster in plectin-deficient compared with wild-type cells; its affinity for vimentin, however, is higher in a reduced, more relaxed conformation PMID: 17224453
    21. We propose a model in which plectin acts as a universal mediator of desmin intermediate filament anchorage at the sarcolemma and Z-disks. PMID: 17389230
    22. These findings establish plectin as the major organizer of desmin IFs in myofibers and provide new insights into plectin- and desmin-related muscular dystrophies. PMID: 18490514
    23. Plectin 1b both forms a mitochondrial signaling platform and affects organelle shape and network formation by tethering mitochondria to intermediate filaments. PMID: 18541706
    24. plectin prevents vimentin networks from complete disassembly during mitosis, facilitating the rebuilding of the intermediate filament network in daughter cells. PMID: 18848541
    25. Plectin contributes to mechanical properties of living cells. PMID: 19244477
    26. Studies demonstrate an important role of plectin in a major nerve function. PMID: 19625254

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.
  • 蛋白家族：
    Plakin or cytolinker family
  • 组织特异性：
    Detected in eye lens fiber cells (at protein level). Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland.
  • 数据库链接：

    KEGG: mmu:18810

    STRING: 10090.ENSMUSP00000073124

    UniGene: Mm.234912

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