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  4. Recombinant Mouse MHC class II transactivator (Ciita), partial

Recombinant Mouse MHC class II transactivator (Ciita), partial

  • 中文名称：
    Recombinant Mouse MHC class II transactivator(Ciita) ,partial
  • 货号：
    CSB-YP005435MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse MHC class II transactivator(Ciita) ,partial
  • 货号：
    CSB-EP005435MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse MHC class II transactivator(Ciita) ,partial
  • 货号：
    CSB-EP005435MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse MHC class II transactivator(Ciita) ,partial
  • 货号：
    CSB-BP005435MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse MHC class II transactivator(Ciita) ,partial
  • 货号：
    CSB-MP005435MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ciita
  • Uniprot No.：
    P79621
  • 别名：
    Ciita; C2ta; Mhc2taMHC class II transactivator; CIITA; EC 2.3.1.-; EC 2.7.11.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones.
  • 基因功能参考文献：
    1. This study provided evidence that CIITA is required for alpha-syn-induced MHCII expression and subsequent infiltration of peripheral immune cells in to the midbrain. PMID: 30165873
    2. study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC subsets, but not over other proposed targets PMID: 28608405
    3. Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC implantation on myocardial repair. PMID: 27221978
    4. M. tuberculosis EsxL inhibits antigen presentation by enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO and p38 MAPK activation PMID: 28209712
    5. this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases PMID: 27861821
    6. CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription PMID: 26972221
    7. NLRC5 and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes. PMID: 25811463
    8. Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice. PMID: 25101797
    9. Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice. PMID: 24987872
    10. IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells. PMID: 24489792
    11. tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression PMID: 11978778
    12. study provides compelling genetic evidence that CIITA, the molecular switch of antigen presentation, plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells PMID: 24038328
    13. Data indicate that during Mycobacterium bovis BCG infection, iNOS/NO responsive KLF4 induces EZH2 and miR-150 functions to regulate CIITA expression. PMID: 23733190
    14. CIITA isoform I is dispensable for proper T-cell development. PMID: 22218223
    15. Mutated major histocompatibility complex class II transactivator up-regulates interleukin-33-dependent differentiation of Th2 subset through Nod2 binding for NLR (NOD-like receptor) signaling initiation. PMID: 22294690
    16. Mice lacking conventional class Ia and class II MHC molecules H2-Kb, H-2Db, and CIITA mediate partial but incomplete virus clearance during acute lymphocytic choriomeningitis virus infection. Clearance is incomplete and chronic infection follows. PMID: 22084437
    17. Data reveal how IFN-gamma modulates myogenesis and demonstrates a key role for CIITA in this process. PMID: 21576360
    18. CIITA mutations alter the immune response without affecting fibrosis PMID: 20705943
    19. Findings indicate that activation of CIITA pIII plays an important role in MHC class II expression in mast cells. PMID: 21321116
    20. The results showed that PR8 selectively affects IFN-gamma induced MHC-II and iNOS expression in both the murine macrophage-like cell line, Raw264.7, and in primary alveolar macrophages. PMID: 21481937
    21. describe the function of a novel splice-isoform of CIITA, dendritic cell-expressed caspase inhibitory isoform of CIITA (or DC-CASPIC) PMID: 21203976
    22. Multiple elements are required to control class II major histocompatibility complex transcriptional coactivator (CIITA) promoter III expression in B cells and provide these cells with the ability to present antigens. PMID: 20363966
    23. When CIITA is induced, the proteins in the proximal and distal conserved sequences make an enhanceosome, allowing chromatin to open and initiate transcription. PMID: 19897249
    24. CIITA gene expression is repressed in class II-negative L1210 cells by methylation of the CIITA upstream regulatory region. PMID: 12218125
    25. Although CIITA is required for MHC class II expression and presentation of peptide antigen by astrocytes, it does not direct expression of other elements in the endocytic pathway that are required for processing and presentation of native CNS autoantigen. PMID: 12471103
    26. Major histocompatibility complex class II (MHCII) expression is regulated by the transcriptional coactivator CIITA. Positive selection of CD4(+) T cells is abrogated in mice lacking one of the promoters (pIV) of the Mhc2ta gene. PMID: 12506036
    27. Il-4 induces a marked up-regulation of CIITA, suggesting a mechanism underlying the IL-4-mediated FasL down-regulation that rescues B cells in Trypanosoma cruzi-infected mice PMID: 12525570
    28. Ectopic expression of a CIITA transgene in multiple mouse cell types does not interfere with normal development of CD4+ T cells; upon TCR activation the CIITA transgenic CD4+ T cells preferentially differentiate into IL-4-secreting Th2-type cells. PMID: 12538670
    29. Silencing of CIITA transcription is recessive in trophoblasts and involves an epigenetic mechanism other than promoter methylation. Trophoblasts may be missing a factor that regulates chromatin structure at the CIITA promoter. PMID: 12748124
    30. ovariectomy-induced bone loss depends on estrogen deficiency-induced increases in class II transactivator in antigen-presenting cells and T cells through augmented interferon-gamma PMID: 12923292
    31. CIITA-deficient murine B cells express increased cathepsin E compared to wild-type B cells. PMID: 15100295
    32. MHC2TA is the single most important transcription factor for the regulation of genes required for MHCII-restricted antigen presentation. PMID: 15162420
    33. A role is defined for CIITA in repressing T helper type 2 (Th2) cytokine expression as naive CD4 T cells differentiate toward the Th1 lineage. PMID: 15494498
    34. ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression PMID: 15964851
    35. Chromatin remodeling at MHC2TA is a novel target of inhibition by Mycobacterium tuberculosis PMID: 16547269
    36. Results show that MHC-II-restricted Ag presentation, and its indirect influences on T cells, remains the only pathway under direct control by CIITA in vivo. PMID: 16703565
    37. Myelosuppressive effects of iron-binding proteins and chemokines on mouse bone marrow HPC require expression of MHC class II antigens, and CIITA is involved in this responsiveness through its regulation of expression of MHC class II antigens. PMID: 16863914
    38. demonstrate the dual defensive role of CIITA against pathogens: it increases the antigen-presenting function for viral determinants and suppresses human T cell leukemia virus type 2 replication in infected cells PMID: 16908858
    39. PKCdelta is an essential signaling molecule to achieve the maximal expression of CIITA PMID: 17346795
    40. LpqH induced expression of C/EBPbeta and C/EBPdelta, and their binding to CIITA pI and pIV, in correlation with inhibition of IFN-gamma-induced expression of CIITA in macrophages, suggesting a role for C/EBP as a novel regulator of CIITA expression. PMID: 17982082
    41. ERK1/2-mediated phosphorylation of CIITA down-regulates CIITA activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation. PMID: 18245089
    42. establish possible cross-talk between the adenosine signaling through cAMP and IFN-gamma during regulation of CIITA expression PMID: 18359773
    43. TSA treatment enhances the association of CIITA with the transcription factor RFX5, which ameliorates the down-regulation of CIITA recruitment to target promoters by HDAC2. PMID: 19041327
    44. Inhibition of type I CIITA is due to blocking of the STAT5-associated epigenetic modifications of the CIITA pI locus during the entire period of Dendritic cells differentiation, as opposed to a simple inhibition of MHC class II expression at the DC stage. PMID: 19224634
    45. genetic polymorphisms in the type I promoter of C2ta regulates differential expression of MHC class II, but not MHC class I, Cd3 and other markers of glial activation. PMID: 19481818

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  • 亚细胞定位：
    Nucleus. Nucleus, PML body.
  • 组织特异性：
    Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and a
  • 数据库链接：

    KEGG: mmu:12265

    STRING: 10090.ENSMUSP00000023147

    UniGene: Mm.249560

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