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  4. Recombinant Mouse Low-density lipoprotein receptor-related protein 4 (Lrp4), partial

Recombinant Mouse Low-density lipoprotein receptor-related protein 4 (Lrp4), partial

  • 中文名称：
    小鼠Lrp4重组蛋白
  • 货号：
    CSB-YP851859MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrp4重组蛋白
  • 货号：
    CSB-EP851859MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrp4重组蛋白
  • 货号：
    CSB-EP851859MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrp4重组蛋白
  • 货号：
    CSB-BP851859MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrp4重组蛋白
  • 货号：
    CSB-MP851859MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrp4
  • Uniprot No.：
    Q8VI56
  • 别名：
    Lrp4; Kiaa0816Low-density lipoprotein receptor-related protein 4; LRP-4; LDLR dan
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation.
  • 基因功能参考文献：
    1. the serum sclerostin levels were strongly increased and the level of sclerostin in the tibia was decreased in Lrp4R1170Q/R1170Q mice, confirming the role of LRP4 as an anchor for sclerostin in bone. PMID: 28477420
    2. The astrocytic Lrp4 plays an important role in ischemic brain injury response. Lrp4 deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling. PMID: 29212737
    3. LRP4 is expressed by embryonic cortical and hippocampal neurons, and downregulation of LRP4 in these neurons causes a reduction in density of synapses and number of primary dendrites. Collectively, the results demonstrate an essential and novel role of neuronal LRP4 in dendritic development and synaptogenesis in the central nervous system. PMID: 29061639
    4. data suggest a model whereby Lrp4 modulates Wnt/beta-catenin signaling via interaction with Wnt ligands and antagonists in a context-dependent manner. PMID: 28694256
    5. a critical role for Lrp4, in response to agrin, in modulating astrocytic ATP release and synaptic transmission PMID: 27294513
    6. We show that prepatterning in mice requires Lrp4 but not the MuSK Fz-like domain PMID: 27151977
    7. The loss of low density lipoprotein receptor-related protein 4 compromised foetal swallowing and breathing-like movements and downregulated the expression of aquaporin-9 in the foetal membrane and aquaporin-1 in the placenta, which possibly affected the amniotic fluid clearance. PMID: 26847765
    8. Reveal novel roles for APP in regulating neuromuscular synapse formation through hetero-oligomeric interaction with LRP4 and agrin and thereby provide new insights into the molecular mechanisms that govern NMJ formation and maintenance. PMID: 23986861
    9. Results suggest that mdig may contribute to silica-induced lung fibrosis by altering the balance between Th17 and Treg cells. PMID: 25669985
    10. These studies demonstrate a role for Lrp4 in hippocampal function. PMID: 25407677
    11. Lrp4 is a critical player in bone-mass homeostasis. PMID: 25733894
    12. found by laser capture microdissection that LRP4 expression was induced during chondrocyte differentiation in the growth plate PMID: 25091481
    13. pathogenic IgG4 antibodies to MuSK bind to a structural epitope in the first Ig-like domain of MuSK, prevent binding between MuSK and Lrp4, and inhibit Agrin-stimulated MuSK phosphorylation. PMID: 24297891
    14. Mice immunized with the extracellular domain of LRP4 generated anti-LRP4 antibodies & exhibited myasthenia-gravis-associated symptoms & neuromuscular junction abnormality. LRP4 contributes to neuromuscular junction maintenance in adulthood. PMID: 24200689
    15. Lrp4 is essential for patterning of the mammary placodes. PMID: 23293290
    16. Lrp4 acts bidirectionally and coordinates synapse formation by binding agrin, activating MuSK and stimulating postsynaptic differentiation, and functioning in turn as a muscle-derived retrograde signal that is necessary and sufficient for presynaptic differentiation PMID: 22854782
    17. Lrp4, lacking the Lrp4 intracellular region, is sufficient for presynaptic and postsynaptic differentiation. PMID: 22038977
    18. Lrp4 is a critical regulator of ureteric bud branching and lack of Lrp4 results in congenital kidney malformations PMID: 20454682
    19. Modulator of cellular signaling pathways involving Wnt proteins, bone morphogenetic proteins, fibroblast growth factors and sonic hedgehog homolog. PMID: 16207730
    20. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells. PMID: 16434236
    21. The gene encoding MEGF7/LRP4, a member of the low-density lipoprotein receptor family, plays an essential role in the process of digit differentiation. PMID: 16517118
    22. Data show that Lrp4 is required during the earliest events in postsynaptic neuromuscular junction (NMJ) formation and suggest that it acts in the early, nerve-independent steps of NMJ assembly. PMID: 17119023
    23. These experiments indicate that Lrp4 is the long-sought and elusive receptor for Agrin and has a critical role in activating MuSK and stimulating neuromuscular synapse formation. PMID: 18848351
    24. These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies. PMID: 18957220
    25. Lrp4 modulates and integrates Bmp and canonical Wnt signalling during tooth morphogenesis by binding the secreted Bmp antagonist protein Wise PMID: 19116665

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  • 相关疾病：
    Defects in Lrp4 are the cause of digitation anormale (dan) phenotype, this mutation is the consequence of a retroviral insertion. Dan mice shown growth retardation in 10-day-old mice dan/dan and polysyndactyly (PubMed:16517118). Defects in Lrp4 are the cause of malformed digits (mdig) phenotype. It is a spontaneous, autosomal recessive mutation resulting in polysyndactyly (PubMed:16517118).
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LDLR family
  • 数据库链接：

    KEGG: mmu:228357

    STRING: 10090.ENSMUSP00000028689

    UniGene: Mm.275149

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