Recombinant Mouse LIM and SH3 domain protein 1 (Lasp1)

^{In Stock}

中文名称：

小鼠Lasp1重组蛋白
货号：

CSB-EP723427MO
规格：

￥1536
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 90% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Lasp1
Uniprot No.：

Q61792
别名：

LASP-1;Metastatic lymph node gene 50 protein;MLN 50
种属：

Mus musculus (Mouse)
蛋白长度：

Full Length
来源：

E.coli
分子量：

36.9 kDa
表达区域：

1-263aa
氨基酸序列

MNPNCARCGKIVYPTEKVNCLDKYWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGVEPERREAQDSSSYRRPTEQQQPQPHHIPTSAPVYQQPQQQQMTSSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

C-terminal 6xHis-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
Datasheet & COA：

Please contact us to get it.

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功能：

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
基因功能参考文献：
1. Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC. PMID: 25385028
2. Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro. PMID: 19531578
3. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
4. Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins. PMID: 15138294
5. Data suggest that there are no functional differences between human and mouse LASP-1. PMID: 15465019
6. The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene. PMID: 18483181
7. role of Lasp1 in chondrocyte differentiation during cartilage to bone transition PMID: 19378260
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亚细胞定位：

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
数据库链接：

KEGG: mmu:16796

STRING: 10090.ENSMUSP00000042123

UniGene: Mm.271967

Recombinant Mouse LIM and SH3 domain protein 1 (Lasp1)

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