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  4. Recombinant Mouse Killer cell lectin-like receptor 8 (Klra8), partial

Recombinant Mouse Killer cell lectin-like receptor 8 (Klra8), partial

  • 中文名称：
    小鼠Klra8重组蛋白
  • 货号：
    CSB-YP720161MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klra8重组蛋白
  • 货号：
    CSB-EP720161MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klra8重组蛋白
  • 货号：
    CSB-EP720161MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klra8重组蛋白
  • 货号：
    CSB-BP720161MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klra8重组蛋白
  • 货号：
    CSB-MP720161MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klra8
  • Uniprot No.：
    Q60682
  • 别名：
    Klra8; Ly-49h; Ly49-h; Ly49H; Killer cell lectin-like receptor 8; Lymphocyte antigen 49h; Ly-49h; T-cell surface glycoprotein Ly-49H
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for class I MHC.
  • 基因功能参考文献：
    1. Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven. PMID: 27831490
    2. Ly49H has a role in antiviral activity. PMID: 23666294
    3. Signaling through the Ly49H receptor is necessary to induce transient Ly49H-mediated natural killer (NK) cell tolerance during chronic viral infection. PMID: 21263069
    4. m157 gene(G1F)-Ly49C interactions cause no apparent attenuating effect on clearance of murine cytomegalovirus from natural killer (NK) cells. PMID: 21187440
    5. In mouse cytomegalovirus(MCMV)-resistant mice, the viral m157 protein engages a related activating receptor (Ly49H) and confers host protection PMID: 11950999
    6. Genetic control of innate immune responses against cytomegalovirus can be attributed to a single genetic locus termed Cmv1. PMID: 12140743
    7. Natural killer cells in New Zealand White mice apparently use a Cmv1-independent mechanism controlled through multiple genes to limit murine cytomegalovirus infection. PMID: 15528370
    8. m157 mutations are predicted to alter the conformation of a putative m157 interface with Ly49H, one that relies on the position of a critical alpha0 helix of m157 PMID: 18566392
    9. transgenic mice were more susceptible to MCMV infection and were unable to reject m157-Tg bone marrow, suggesting defects in Ly49H(+) NK cells PMID: 18606857
    10. Ly49h is necessary for genetic resistance to murine cytomegalovirus. PMID: 18668236
    11. Ly49H-positive natural killer (NK) cells contain a systemic production of cytokines that may contribute to murine cytomegalovirus-induced pathology and play a central role in maintaining normal spleen cell microarchitecture. PMID: 18941230
    12. Optimal natural killer cell-mediated immunity to cytomegalovirus depends on Ly49H signaling through DAP10 and DAP12. PMID: 19332875
    13. Ly49H-regulated NK-cell control of murine CMV infection is dependent on pfp-mediated cytolysis. PMID: 19564888
    14. NK cell expansion is increased through an Ly49H-dependent pathway to promote alternative beneficial effects. PMID: 19720840

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 数据库链接：

    KEGG: mmu:16639

    STRING: 10090.ENSMUSP00000014476

    UniGene: Mm.439698

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