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  4. Recombinant Mouse Fructosamine-3-kinase (Fn3k)

Recombinant Mouse Fructosamine-3-kinase (Fn3k)

  • 中文名称：
    小鼠Fn3k重组蛋白
  • 货号：
    CSB-YP866825MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fn3k重组蛋白
  • 货号：
    CSB-EP866825MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fn3k重组蛋白
  • 货号：
    CSB-EP866825MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fn3k重组蛋白
  • 货号：
    CSB-BP866825MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fn3k重组蛋白
  • 货号：
    CSB-MP866825MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fn3k
  • Uniprot No.：
    Q9ER35
  • 别名：
    Fn3kFructosamine-3-kinase; EC 2.7.1.171; Protein-psicosamine 3-kinase FN3K; Protein-ribulosamine 3-kinase FN3K; EC 2.7.1.172
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-309
  • 氨基酸序列
    MEQLLRAQLH TTTLRAFGSS GGGCISEGYA YYTDSGPVFV KVNRRTQARQ MFEGEMASLE ALRNTGLVRV PKPMKVIDLP GGGAVFVMEH LKMKSLSSQA SKLGEQMADL HLYNQKLREK SKTRQNTVGC GAEGAEPQGV TKFGFHTVTC CGFIPQVNEW QEDWPTFFTR HRLQAQLDLI EKDYADRETQ ELWSRLQVKI PDLFAGIEIV PALLHGDLWS GNVAEDDQGP VIYDPASFYG HSEFELAIAS MFGGFPRSFF TAYHRKIPKA PGFDKRLLLY QLFNYLNHWN HFGREYRSPS LGVMRKLLR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes and pancreatic islets. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
  • 基因功能参考文献：
    1. Data conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention. PMID: 29066600
    2. We conclude that, despite its ability to reduce the glycation of intracellular islet proteins, FN3K is neither required for the maintenance of beta-cell survival and function under control conditions. PMID: 20009024
    3. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate PMID: 15331600
    4. These data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine. PMID: 16819943
  • 蛋白家族：
    Fructosamine kinase family
  • 组织特异性：
    Expressed in red blood cells, brain, heart, kidney and muscle. Lower expression is observed in liver. Not expressed in lung, spleen, testis and thymus.
  • 数据库链接：

    KEGG: mmu:63828

    STRING: 10090.ENSMUSP00000026175

    UniGene: Mm.266448

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