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  4. Recombinant Mouse Folylpolyglutamate synthase, mitochondrial (Fpgs)

Recombinant Mouse Folylpolyglutamate synthase, mitochondrial (Fpgs)

  • 中文名称：
    小鼠Fpgs重组蛋白
  • 货号：
    CSB-YP008851MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fpgs重组蛋白
  • 货号：
    CSB-EP008851MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fpgs重组蛋白
  • 货号：
    CSB-EP008851MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fpgs重组蛋白
  • 货号：
    CSB-BP008851MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fpgs重组蛋白
  • 货号：
    CSB-MP008851MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fpgs
  • Uniprot No.：
    P48760
  • 别名：
    FpgsFolylpolyglutamate synthase; mitochondrial; EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    43-587
  • 氨基酸序列
    MEYQDAVR TLNTLQTNAS YLEQVKRQRS DPQAQLEAME MYLARSGLQV EDLNRLNIIH VTGTKGKGST CAFTERILRN YGLKTGFFSS PHMVQVRERI RINGKPISPE LFTKHFWCLY NQLEEFKDDS HVSMPSYFRF LTLMAFHVFL QEKVDLAVVE VGIGGAFDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA WQKGGIFKPG VPAFTVVQPE GPLAVLRDRA QQIGCPLYLC PPLEALEEVG LPLSLGLEGA HQRSNAALAL QLAHCWLERQ DHQDIQELKV SRPSIRWQLP LAPVFRPTPH MRRGLRDTVW PGRTQILQRG PLTWYLDGAH TTSSVQACVH WYRQSLERSK RTDGGSEVHI LLFNSTGDRD SAALLKLLQP CQFDYAVFCP NVTEVSSIGN ADQQNFTVTL DQVLLRCLQH QQHWNGLAEK QASSNLWSSC GPDPAGPGSL LLAPHPPQPT RTSSLVFSCI SHALLWISQG RDPIFQPQSL PRNLLNHPTA NSGASILREA AAIHVLVTGS LHLVGGVLKL LDPSMSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates.
  • 基因功能参考文献：
    1. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. PMID: 12663051
    2. These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU. PMID: 18035049
  • 亚细胞定位：
    [Isoform 1]: Mitochondrion inner membrane. Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Folylpolyglutamate synthase family
  • 组织特异性：
    With non-specific probe, highest content in kidney and liver and lowest in spleen, lung and small intestine, and readily detectable in all of the tumors except hepatoma. Isoform 1 and isoform 2 expressed in leukemic cells and isoform 4 and isoform 5 in li
  • 数据库链接：

    KEGG: mmu:14287

    STRING: 10090.ENSMUSP00000028148

    UniGene: Mm.3830

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