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  4. Recombinant Mouse Fatty acid-binding protein, adipocyte (Fabp4)

Recombinant Mouse Fatty acid-binding protein, adipocyte (Fabp4)

In Stock
  • 中文名称：
    Recombinant Mouse Fatty acid-binding protein, adipocyte (Fabp4)
  • 货号：
    CSB-YP007945MO
  • 规格：
    ￥1500
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Fabp4
  • Uniprot No.：
    P04117
  • 别名：
    3T3-L1 lipid-binding protein;Adipocyte lipid-binding protein;ALBP;Adipocyte-type fatty acid-binding protein;A-FABP;AFABP;Fatty acid-binding protein 4;Myelin P2 protein homolog;P15;P2 adipocyte protein;Protein 422
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    16.0 kDa
  • 表达区域：
    2-132aa
  • 氨基酸序列
    CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Fabp4 Proteins

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靶点详情

  • 功能：
    Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
  • 基因功能参考文献：
    1. The findings chart the pathway of FABP4 secretion and provide a potential therapeutic means to control metabolic disorders associated with its dysregulated secretion. PMID: 29212659
    2. Study in A-FABP knockout mice revealed that A-FABP acts as a physiological stimulator of brown adipose tissue-mediated adaptive thermogenesis. PMID: 28128199
    3. Fabp4/5 confers protection against metabolic diseases but does not extend lifespan. PMID: 29020626
    4. Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury. PMID: 28903937
    5. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages PMID: 28546450
    6. Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction. PMID: 29158087
    7. Collectively, these results demonstrate that C. pneumoniae exploits host FABP4 to facilitate fat mobilization and intracellular replication in adipocytes. This work uncovers a novel strategy used by intracellular pathogens for acquiring energy via hijacking of the host lipid metabolism pathway. PMID: 29108997
    8. High Fabp4 expression is associated with Acute myeloid leukemia. PMID: 27885273
    9. These data suggest that the function of SIRT6 in the Fabp4-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis. PMID: 28385723
    10. This study demonstrating a FABP4-UCP2 axis with the potential to modulate the microglial inflammatory response. PMID: 28214555
    11. our data establish A-FABP as a new molecular sensor in triggering macrophage-associated sterile inflammation in obesity. PMID: 27920274
    12. these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression. PMID: 27795298
    13. FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis. PMID: 27013610
    14. endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes PMID: 27297106
    15. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 and SirT3. PMID: 26789108
    16. FABP4 could reverse the activation of the leptin-induced mitochondrial fatty acid oxidation. PMID: 26310911
    17. FABP4 is a hypoxia inducible gene that sensitizes mice to liver I/R injury. PMID: 26070408
    18. Data suggest Fabp4 is up-regulated and DNA methylation is down-regulated in aorta in hyperhomocysteinemia induced by high-methionine diet; up-regulation of DNA methyltransferase 1 (Dnmt1) promotes DNA methylation and decreases Fabp4 expression. PMID: 26606905
    19. Data show that the weight gain was blunted in male, but not female, fatty acid binding protein 4-Cre-driven promoter (FaChOX) mice when placed on either a normal chow diet or an obesogenic Western diet. PMID: 26248218
    20. Data show that overexpression of cattle adipocyte fatty acid-binding protein (A-FABP)gene promoted fat deposition in the skeletal muscle of transgenic mice. PMID: 25867423
    21. Data suggest that expression of Fabp4 (fatty acid binding protein 4) in preadipocytes is up-regulated by arachidonic acid during adipogenesis; this up-regulation appears mediated by prostaglandin F2alpha/FP (prostaglandin F2alpha receptor) signaling. PMID: 25325755
    22. results show that chemical inhibition of lipase activity, genetic deficiency of adipose triglyceride lipase and, to a lesser extent, hormone-sensitive lipase blocked aP2 secretion from adipocytes. PMID: 25535287
    23. FABP4-/- mice demonstrated a significant decrease in neovessel formation and significant improvement in physiological revascularization. PMID: 24802082
    24. A-FABP deficiency protects mice against MI/R-induced and/or diabetes-induced cardiac injury at least partially through activation of the eNOS/NO pathway and reduction in superoxide anion production PMID: 26186740
    25. -). As Cre-loxP-mediated genetic lineage tracing is irreversible and heritable, the genetic labelling (RFP) would inevitably label all descendants of these early FABP4+ embryonic VECs, regardless of whether they express CreER at P7 or not. PMID: 25265869
    26. FABP4 is expressed in the mouse placental labyrinth, with highest expression at E16.5. FABP4 is dispensable for feto-placental growth and placental lipid accumulation. PMID: 25096952
    27. The present results demonstrate that deletion of IL-6 driven by a fatty acid binding protein (aP2) promoter-Cre inducible system regulates body weight, body fat and metabolism in a sex-specific fashion. PMID: 24934978
    28. miR-24 plays an important role in regulating adipocyte differentiation and FABP4 expression. The mechanism involved may be the upregulation of AP-1. PMID: 24301787
    29. FABP4/5 play an indispensable role in thermogenesis in brown adipose tissue and skeletal muscle. PMID: 24603714
    30. peripheral uptake of FA via capillary endothelial FABP4/5 is crucial for systemic metabolism and may establish FABP4/5 as potentially novel targets for the modulation of energy homeostasis. PMID: 24244493
    31. In aP2-Cre/ERalpha(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus. PMID: 24416430
    32. found that the FABP4 level was higher and PPARgamma level was lower in human visceral fat and mouse epididymal fat compared with their subcutaneous fat PMID: 24319114
    33. Neutralization of secreted aP2 reduces glucose production. PMID: 23663740
    34. lower dermis adipose layer development is signalled by expression of FABP4 PMID: 23555789
    35. Capillary endothelial FABP4/5 are required for (fatty acid)FA transport into FA-consuming tissues that include the heart. PMID: 23968980
    36. High Fabp4 expression is associated with atherosclerotic lesion. PMID: 23387955
    37. FABP4 promotes VEGF-induced airway angiogenesis. PMID: 23391391
    38. FABP4 expression in adipose and hepatic tissues in the settings of obesity and insulin resistance, was analyzed. PMID: 23139800
    39. fatty acid binding protein 4 (FABP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for differentiated adipocytes. However, whether aP2 is expressed in adipogenic progenitors is controversial PMID: 23047894
    40. These findings indicate that FABP4 may have a crucial role in modulating IL-6 and vascular endothelial growth factor as angiogenesis inducers stimulated by the cellular action of thrombin on adipocytes via PAR1. PMID: 23008513
    41. fatty acid-binding protein (FABP4), an intracellular fatty acid chaperone, in the mouse thymus, and examined its role in the control of cytokine production PMID: 22585040
    42. In the aP2-Cre mice, the recombinase activity is expressed in the central nervous system of the embryos. PMID: 22150821
    43. Report statins/dexamethasone synergistically induce FABP4 expression in macrophages. PMID: 22503826
    44. Unsaturated fatty acids inhibited the basal as well as lipopolysaccharides induced Adipocyte fatty acid binding protein expression. PMID: 21046125
    45. Fabp4 is highly expressed in mouse decidua. In vitro decidualization is significantly stimulated by Fabp4 overexpression and inhibited by Fabp4 siRNA and FABP4 inhibitor. PMID: 21704217
    46. Results define a new class of in vivo ligands for aP2 and other fatty acid binding proteins and extend their physiological substrates to include bioactive aldehydes. PMID: 20509169
    47. The lack of aP2 in donor marrow cells led to the development of smaller (5.5-fold) atherosclerotic lesions in the recipient mice. PMID: 11606480
    48. data provide support for the portal region hypothesis and suggest dynamic fluctuations in this region regulate cavity access, but not ligand affinity or selectivity PMID: 11827549
    49. Ap2-deficient mice with advanced atherosclerosis and severe hypercholesterolemia fed a Western diet for 14 weeks have significant reductions in mean atherosclerotic lesion size in the proximal aorta, en face aorta, and innominate/right carotid artery. PMID: 12377750
    50. A-FABP and E-FABP bind to hormone-sensitive lipase with high affinity PMID: 13129924

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    KEGG: mmu:11770

    STRING: 10090.ENSMUSP00000029041

    UniGene: Mm.582

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