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  4. Recombinant Mouse Enhancer of filamentation 1 (Nedd9), partial

Recombinant Mouse Enhancer of filamentation 1 (Nedd9), partial

  • 中文名称：
    小鼠Nedd9重组蛋白
  • 货号：
    CSB-YP015685MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nedd9重组蛋白
  • 货号：
    CSB-EP015685MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nedd9重组蛋白
  • 货号：
    CSB-EP015685MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nedd9重组蛋白
  • 货号：
    CSB-BP015685MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nedd9重组蛋白
  • 货号：
    CSB-MP015685MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nedd9
  • Uniprot No.：
    O35177
  • 别名：
    Nedd9; CaslEnhancer of filamentation 1; mEF1; CRK-associated substrate-related protein; CAS-L; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; p105
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells.
  • 基因功能参考文献：
    1. a new role for Cas-L in T-cell activation, is reported. PMID: 27359298
    2. NEDD9 is required for the maintenance of dendritic spines in the hippocampus. PMID: 26683084
    3. NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review) PMID: 26324022
    4. Thus the RARE upstream of the Nedd9 2B promoter is necessary for much of the endogenous gene expression during early development as well as ectopic expression in response to atRA. PMID: 25120220
    5. suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA, and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA PMID: 25847598
    6. Data indicate that Src kinase modulates the transit time of NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesion sites. PMID: 25059660
    7. These results indicated an important modifier action of Nedd9 on autosomal dominant polycystic kidney disease pathogenesis involving failure to activate Aurora-A. PMID: 25139996
    8. these results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells PMID: 23318423
    9. Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics. PMID: 23874939
    10. Collectively our data suggest that NEDD9 may promote 3D cell migration by slowing focal adhesion disassembly, promoting integrin receptor activation and increasing adhesion force PMID: 22509381
    11. Cas-L seems to regulate the progression of CML in a negative way, presumably by attenuating extramedullary hyperplasia PMID: 21848808
    12. Cas proteins do not affect E-cadherin transcription, but rather, BCAR1 and NEDD9 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation. PMID: 21765937
    13. Mammary tumor cells lacking NEDD9 is associated with enhanced genetic instability and dasatinib sensitivity. PMID: 20940402
    14. SHEP1 and CasL are constitutively associated in B cells. PMID: 20956287
    15. Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion PMID: 16148091
    16. Nedd9 has a role in the differentiation of neurons after ischemia PMID: 16210561
    17. Cellular localization of NEDD9 expression during embryonic development. PMID: 18282814
    18. Nedd9 promotes the migration of NCCs in a graded manner and suggest a role for RA in the control of Nedd9 expression levels. PMID: 19464348

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  • 亚细胞定位：
    Cytoplasm, cell cortex. Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    CAS family
  • 组织特异性：
    Expressed in splenic lymphocytes (at protein level).
  • 数据库链接：

    KEGG: mmu:18003

    STRING: 10090.ENSMUSP00000021794

    UniGene: Mm.288980

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