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  4. Recombinant Mouse Dachshund homolog 1 (Dach1)

Recombinant Mouse Dachshund homolog 1 (Dach1)

  • 中文名称：
    Recombinant Mouse Dachshund homolog 1(Dach1)
  • 货号：
    CSB-YP870766MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 1(Dach1)
  • 货号：
    CSB-EP870766MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 1(Dach1)
  • 货号：
    CSB-EP870766MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 1(Dach1)
  • 货号：
    CSB-BP870766MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 1(Dach1)
  • 货号：
    CSB-MP870766MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dach1
  • Uniprot No.：
    Q9QYB2
  • 别名：
    Dach1; DachDachshund homolog 1; Dach1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-751
  • 氨基酸序列
    MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI ASSASSSAAA TVTSPGGGGG GSGGGGGSGG NGGGGGSNCN PSLAAGSSGG GVSAGGGGAS STPITASTGS SSSSSSSSSS SSSSSSSSSS SSSSSSCGPL PGKPVYSTPS PVENTPQNNE CKMVDLRGAK VASFTVEGCE LICLPQAFDL FLKHLVGGLH TVYTKLKRLE ITPVVCNVEQ VRILRGLGAI QPGVNRCKLI SRKDFETLYN DCTNASSRPG RPPKRTQSVT SPENSHIMPH SVPGLMSPGI IPPTGLTAAA AAAAAATNAA IAEAMKVKKI KLEAMSNYHA SNNQHGADSE NGDMNSSVGS SGGSWDKETL HSPPSQGSQA PVAHARMPAA FSLPVSHPLN HLQHSHLPPN GLELPFMMMP HPLIPVSLPP ASVTMAMSQM NHLSTIANMA AAAQVQSPPS RVETSVIKER VPDSPSPAPS LEEGRRPGSH PSSHRSSSVS SSPARTESSS DRIPVHQNGL SMNQMLMGLS PNVLPGPKEG DLAGHDMGHE SKRIHIEKDE TPLSTPTARD SIDKLSLTGH GQPLPPGFPS PFLFPDGLSS IETLLTNIQG LLKVAIDNAR AQEKQVQLEK TELKMDFLRE RELRETLEKQ LAMEQKNRAI VQKRLKKEKK AKRKLQEALE FETKRREQAE QTLKQAASAD SLRVLNDSLT PEIEADRSGG RADAERTIQD GRLYLKTTVM Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
  • 基因功能参考文献：
    1. DACH1 stimulates coronary artery growth by activating Cxcl12 expression and endothelial cell migration against blood flow into developing arteries PMID: 28779009
    2. HDAC4-mediated SUMOylation of the corepressor DACH1 is decreased, which protects DACH1 from proteasomal degradation PMID: 27239042
    3. The results of this study suggested the involvement of the mouse Dach1 gene in adult neurogenesis; cells expressing this gene exhibit the properties of adult NSCs or neuroblasts and respond to MCAo by enhanced neurogenesis. PMID: 23458709
    4. find that in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity PMID: 21558809
    5. The mouse dachshund gene is related to the Ski proto-oncogene and is expressed in eye and limb. PMID: 9651501
    6. In the mouse, Dach1 expression in the developing ear also overlaps with the expression of Eya1 (an eya homologue) PMID: 11804780
    7. D6 enhancer exerts highly tissue-specific activity in neurons of the neocortex and hippocampus and in neural stem cells. PMID: 12088753
    8. Dach1 is a target gene of FGF signaling during limb skeletal development, and Dach1 may function as an intermediary in the FGF signaling pathway regulating cell proliferation or differentiation PMID: 12203718
    9. Dach1 is critical for postnatal survival of mice PMID: 12508235
    10. The phosphatase function of Eya switches the function of Six1-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators PMID: 14628042
    11. The Pax-Eya-Six-Dach network is at best only partly conserved during lens and nasal placode development. PMID: 16024294
    12. These studies demonstrate a novel mechanism by which DACH1 blocks c-Jun-mediated contact-independent growth through repressing the c-Jun delta domain. PMID: 17182846
    13. With Dach2, may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct. PMID: 18395837
    14. These data identify a pathway by which an endogenous cell-fate determination factor blocks oncogene-dependent tumor metastasis via a key heterotypic mediator. PMID: 18467491

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DACH/dachshund family
  • 组织特异性：
    Expressed at higher levels in adult kidney and lung, and at lower levels in brain and testis. Expressed in embryonal kidneys, eyes, cochleae and limb buds.
  • 数据库链接：

    KEGG: mmu:13134

    STRING: 10090.ENSMUSP00000071464

    UniGene: Mm.320593

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