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  4. Recombinant Mouse Contactin-6 (Cntn6), partial

Recombinant Mouse Contactin-6 (Cntn6), partial

  • 中文名称：
    Recombinant Mouse Contactin-6(Cntn6) ,partial
  • 货号：
    CSB-YP872893MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-6(Cntn6) ,partial
  • 货号：
    CSB-EP872893MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-6(Cntn6) ,partial
  • 货号：
    CSB-EP872893MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-6(Cntn6) ,partial
  • 货号：
    CSB-BP872893MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Contactin-6(Cntn6) ,partial
  • 货号：
    CSB-MP872893MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cntn6
  • Uniprot No.：
    Q9JMB8
  • 别名：
    Cntn6Contactin-6; Neural recognition molecule NB-3; mNB-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
  • 基因功能参考文献：
    1. The common phenotypic features of 40 patients with microdeletions and microduplications of CNTN6 appeared to be the autism spectrum disorders, developmental delay, intellectual disability, seizures, cognitive impairment, cardiological defects, and behavioral problems. PMID: 29369566
    2. Cntn6 engages in both trans- and cis-interactions and may be involved in larger protein interaction networks. PMID: 26939565
    3. These findings demonstrate that NB-3 trans-homophilic interactions mediate the cross-talk between post-traumatic axons and scar-forming cells and impair the intrinsic growth ability of injured axons. PMID: 27192985
    4. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system PMID: 27539848
    5. our data suggest that adropin is a membrane-bound protein that interacts with the brain-specific Notch1 ligand NB3 PMID: 25074942
    6. NB-3 is involved in the normal projection and terminal branching of developing corticospinal tract axons. PMID: 21935948
    7. the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development PMID: 21622556
    8. NB-3 has key roles in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. PMID: 20176085
    9. Mice deficient for NB-3 are slow to learn to stay on the rotating rod in the rotorod test during repeated trials and display dysfunction of equilibrium and vestibular senses in the wire hang and horizontal rod-walking tests. PMID: 12884264
    10. NB-3/Notch1 pathway promotes neural progenitor cell differentiation into oligodendrocytes via Deltex1. PMID: 15082708
    11. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity in the developing caudal cortex. PMID: 18046458
    12. Collectively, our results indicate that NB-3 deficiency affects synapse formation during postnatal cerebellar development. PMID: 19672956

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 组织特异性：
    Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Pu
  • 数据库链接：

    KEGG: mmu:53870

    STRING: 10090.ENSMUSP00000086623

    UniGene: Mm.321671

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