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  4. Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A (Cc2d1a), partial

Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A (Cc2d1a), partial

  • 中文名称：
    Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A(Cc2d1a) ,partial
  • 货号：
    CSB-YP809079MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A(Cc2d1a) ,partial
  • 货号：
    CSB-EP809079MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A(Cc2d1a) ,partial
  • 货号：
    CSB-EP809079MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A(Cc2d1a) ,partial
  • 货号：
    CSB-BP809079MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil and C2 domain-containing protein 1A(Cc2d1a) ,partial
  • 货号：
    CSB-MP809079MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cc2d1a
  • Uniprot No.：
    Q8K1A6
  • 别名：
    Cc2d1a; Coiled-coil and C2 domain-containing protein 1A; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses.
  • 基因功能参考文献：
    1. Cc2d1a conditional knockout mice therefore recapitulate features of both cognitive and social impairment caused by human CC2D1A mutation PMID: 26826102
    2. Freud-1 is crucial for 5-HT1A autoreceptor expression and links up-regulation of 5-HT1A autoreceptors to anxiety/depression-like behavior. PMID: 29101244
    3. CC2D1A and CC2D1B role and function in the endocytic pathway and Notch signalling. PMID: 26720614
    4. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity PMID: 22833682
    5. Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses. PMID: 21273312
    6. Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation. PMID: 21090244
    7. Freud-1 has a key role in regulating DRD2 expression PMID: 17535813
    8. Paper describes a function of Cc2d1a/Cc2d1b and its Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. PMID: 17084358
    9. Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression. PMID: 12917378

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CC2D1 family
  • 组织特异性：
    Highly expressed in brain, expression is enriched in the gray matter and strongest in the olfactory bulb.
  • 数据库链接：

    KEGG: mmu:212139

    STRING: 10090.ENSMUSP00000046449

    UniGene: Mm.41424

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