Recombinant Mouse B-cell lymphoma/leukemia 11B (Bcl11b), partial

1. Mice lacking Bcl11b in mature T-cells have a diminished capacity to mount Th2 responses during helminth infection and allergic asthma, showing reduced Th2 cytokines and Gata3, and elevated Runx3. PMID: 29700302
2. Thus, this study identifies BCL11B as a novel regulator of adipogenesis, which works, at least in part, by stimulating C/EBPbeta activity and suppressing the Wnt/beta-catenin signaling pathway. PMID: 27586877
3. Bcl11b is associated with cell fate in the T-cell gene regulatory network. PMID: 28584128
4. Bcl11b, known as a T-lineage commitment factor, is essential for proper expression of ThPOK and Runx3, central regulators for the CD4-helper/CD8-cytotoxic lineage choice. PMID: 28951542
5. Authors provide insight into the mechanism that underpins the repositioning of regulatory elements; identify a non-coding RNA, named ThymoD, which acts to reposition the Bcl11 enhancer away from the lamina to the nuclear interior and sequester the Bcl11b promoter and enhancer region into a single-loop domain. PMID: 28938112
6. key regulator of Invariant natural killer T-cell effector subsets, their function, identity, and survival PMID: 27330109
7. these results suggest that Bcl11b acts as a central intrinsic regulator of mammary epithelial stem cell quiescence. PMID: 28041896
8. BCL11B is expressed in both osteogenic and sutural mesenchyme of the developing craniofacial complex. Bcl11b(-/-) mice exhibit increased proliferation of osteoprogenitors, premature osteoblast differentiation, and enhanced skull mineralization leading to synostoses of facial and calvarial sutures. PMID: 26453795
9. the expression and function of Bcl11b in the oral epithelium and demonstration that Bcl11b is an essential regulator for keratinocyte differentiation and the morphogenesis of papillary structure of the lingual epithelium. PMID: 27287879
10. BCL11B as a regulator of energy metabolism PMID: 28067590
11. Data uncover for the first time a specific role of Bcl11b in adult hippocampal neurogenesis and function. PMID: 26915960
12. BCL11B is extensively expressed in neocortical GABAergic interneurons of all three major subgroups and thus its expression is not restricted to subcerebral projections cells. PMID: 26698402
13. Bcl11b regulates development of different thymocyte subsets at multiple stages and prevents an excess of innate CD8 single-positive thymocytes. PMID: 25422283
14. sustains mature Type 2 innate lymphoid cells genetic and functional programs and lineage fidelity PMID: 26231117
15. Data indicate kinetic changes in relative phosphorylation on 18 of 23 serine and threonine residues and sumoylation on one of two lysine resides in B-cell lymphoma-leukemia 11B protein BCL11B. PMID: 25423098
16. BCL11B is expressed to potentially regulate the transition of mesenchymal differentiation and suture formation within craniofacial intramembranous bone. PMID: 25511173
17. Bcl11b is essential for group 2 innate lymphoid cell development PMID: 25964370
18. Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development PMID: 25964371
19. Deletion junctions in Bcl11b exhibit greater germline nucleotide loss. PMID: 24530429
20. mice deficient in Bcl11b in T cells, although having reduced numbers of T cells in the peripheral lymphoid organs, developed significantly less tumors compared with wild-type mice. PMID: 24446520
21. The incisor maintenance by Bcl11b is intrinsic to ameloblast progenitors and possibly stem cells. PMID: 23727454
22. Half (9/18) of the thymuses in the Bcl11b(flox/+) ;Lck-Cre group showed limited rearrangement sites at the T-cell receptor-beta (TCRbeta) locus. PMID: 23663453
23. CTIP2 controls P-TEFb function in physiological and pathological conditions. PMID: 23852730
24. the downstream enhancer for murine Bcl11b controls its T-cell specific expression PMID: 23741008
25. Findings demonstrate a novel mechanism(s) of Ctip2-mediated, coordinated control of epidermal proliferation and terminal differentiation, and identify a pathway of negative feedback regulation of Ctip2 during epidermal development. PMID: 23015591
26. the role of Ctip2 in adult skin homeostasis PMID: 23284675
27. Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. PMID: 23096701
28. the CB(1) receptor contributes to the generation of deep-layer cortical neurons by coupling endocannabinoid signals from the neurogenic niche to the intrinsic proneurogenic Ctip2/Satb2 axis PMID: 23175820
29. BCL11B is a key factor controlling epithelial proliferation and overall developmental asymmetry of the mouse incisor. PMID: 22629441
30. Data show that Bcl11b is indispensable for T(reg) suppressor function and for maintenance of optimal Foxp3 and IL-10 gene expression, as well as for the induction of Foxp3 expression in CD4(+) T cells in response to Tgf-beta and generation of iT(reg) cells. PMID: 21875956
31. Bcl11b phospho-deSUMO switch was identified, the basis of which was phosphorylation-dependent recruitment of the SUMO hydrolase SENP1 to phospho-Bcl11b, coupled to hydrolysis of SUMO-Bcl11b PMID: 22700985
32. The data defined an important novel regulatory pathway in hippocampal development, by linking transcriptional functions of Bcl11b to Desmoplakin. PMID: 22588081
33. Those phenotypes provided by loss of a Bcl11b allele favor that Bcl11b mutation belongs to type B abnormalities. PMID: 22640496
34. keratinocytic Ctip2 has a role in modulating cell migration, proliferation and/or differentiation, and to maintain HF stem cells during cutaneous wounding PMID: 22383956
35. Satb2 is a partner of Ski. Both are required for transcriptional repression of Ctip2 in callosal neurons. Satb2 recruits Ski to the Ctip2 locus. PMID: 22334647
36. Bcl11b as a novel regulator of the BDNF signaling pathway PMID: 21912641
37. These results suggest that the age-related hearing loss observed in Bcl11b (+/-) mice is the result of impairment of the outer hair cells and that BCL11B activity is required for the maintenance of outer hair cells and normal hearing. PMID: 21791875
38. These results indicate that Bcl11b/Ctip2 is an essential regulator of the differentiation and dichotomy of vomeronasal sensory neurons PMID: 21752992
39. These studies demonstrate a unique and previously undescribed role of Bcl11b in double-positive thymocytes, in addition to the critical function in positive selection of conventional CD4 and CD8 single-positive thymocytes. PMID: 21444811
40. represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes PMID: 20544728
41. The transcription factor Bcl11b/Ctip2 controls hallmark features of CD8(+) T cell immunity, specifically antigen-dependent clonal expansion and cytolytic activity. PMID: 20660613
42. the Bcl11b(KO/+) genotype contributes to clonal expansion and differentiation arrest in part through an increase in the level of beta-catenin. PMID: 20384631
43. study found that Bcl11b is necessary for T lineage commitment and is specifically required both to repress natural killer cell-associated genes and to down-regulate a battery of stem cell or progenitor cell genes at the pivotal stage of commitment PMID: 20595614
44. study identifies the earliest checkpoint during T cell development and shows that it is Bcl11b-dependent PMID: 20595615
45. findings show that Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development; when deleted, T cells from all developmental stages acquired NK cell properties and lost or decreased T cell-associated gene expression PMID: 20538915
46. These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development. PMID: 12565905
47. Bcl11b is a key regulator of both differentiation and survival during thymocyte development. PMID: 12717433
48. CTIP1 and CTIP2 have roles in the development and function of both the central nervous and immune systems PMID: 15465497
49. BCL11B, originally described as a transcriptional repressor, activates transcription of a target gene in the context of T-cell activation. PMID: 16809611
50. Bcl11b has a role in response to DNA replication stress and damages PMID: 17369851

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KEGG: mmu:58208

STRING: 10090.ENSMUSP00000068258

UniGene: Mm.392694