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  4. Recombinant Human SRC kinase signaling inhibitor 1 (SRCIN1), partial

Recombinant Human SRC kinase signaling inhibitor 1 (SRCIN1), partial

  • 中文名称：
    人SRCIN1重组蛋白
  • 货号：
    CSB-YP863179HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SRCIN1重组蛋白
  • 货号：
    CSB-EP863179HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SRCIN1重组蛋白
  • 货号：
    CSB-EP863179HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SRCIN1重组蛋白
  • 货号：
    CSB-BP863179HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SRCIN1重组蛋白
  • 货号：
    CSB-MP863179HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SRCIN1
  • Uniprot No.：
    Q9C0H9
  • 别名：
    p130Cas associated protein; p130Cas-associated protein; P140; p140Cap; SNAP-25-interacting protein; SNIP; SRC kinase signaling inhibitor 1; SRCIN1; SRCN1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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SRCIN1 antibodies

靶点详情

  • 功能：
    Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • 基因功能参考文献：
    1. SRCIN1 functions to inhibit the proliferation and EMT of human liver cancer HepG2 cells. PMID: 28550679
    2. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. PMID: 28300085
    3. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
    4. SRCIN1 underexpression is associated with Osteosarcoma. PMID: 27513473
    5. Together, these results demonstrate that Srcin1 contributes to CRC carcinogenesis, invasion and metastasis. These findings provide a rationale for a mechanistic approach to CRC treatment based on the development of Srcin1-targeted therapies PMID: 28393242
    6. miR-211 may function as an oncogenic miRNA in non-small cell lung cancer, partly by regulating SRCIN1 PMID: 26277787
    7. miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer PMID: 27913185
    8. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    9. these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 PMID: 25554419
    10. Findings indicate the role of miR-150 as an oncogene in lung cancer through the inhibition of SRC kinase signalling inhibitor 1 (SRCIN1) translation. PMID: 24456795
    11. p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
    12. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. PMID: 20453886
    13. provides the first evidence that p140Cap is a novel negative regulator of tumour growth PMID: 17525734
    14. Expression correlated significantly with unfavourable overall survival, suggesting that SNIP/p140Cap may be a useful diagnostic and prognostic marker, aas well as therapeutic target, in breast cancer. PMID: 18475297

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    SRCIN1 family
  • 组织特异性：
    Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • 数据库链接：

    HGNC: 29506

    OMIM: 610786

    KEGG: hsa:80725

    STRING: 9606.ENSP00000264659

    UniGene: Hs.448872

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