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  4. Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial

Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial

  • 中文名称：
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 货号：
    CSB-YP744417HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 货号：
    CSB-EP744417HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 货号：
    CSB-EP744417HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 货号：
    CSB-BP744417HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial
  • 货号：
    CSB-MP744417HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF18
  • Uniprot No.：
    Q6ZSZ5
  • 别名：
    114 kDa Rho specific guanine nucleotide exchange factor; 114 kDa Rho-specific guanine nucleotide exchange factor; ARHGEF 18; Arhgef18; ARHGI_HUMAN; KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide exchange factor 18; SA RhoGEF; SA-RhoGEF; Septin associated RhoGEF; Septin-associated RhoGEF
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

ARHGEF18 antibodies

靶点详情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.
  • 基因功能参考文献：
    1. mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy PMID: 28132693
    2. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels. PMID: 26217016
    3. LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly. PMID: 23648482
    4. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. PMID: 23185572
    5. In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions. PMID: 22006950
    6. Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis. PMID: 21258369
    7. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. PMID: 20810787
    8. data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions PMID: 14512443

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  • 相关疾病：
    Retinitis pigmentosa 78 (RP78)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane.
  • 组织特异性：
    Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Is
  • 数据库链接：

    HGNC: 17090

    OMIM: 616432

    KEGG: hsa:23370

    STRING: 9606.ENSP00000352995

    UniGene: Hs.465761

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