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  4. Recombinant Human Ras-related protein Rap-2a (RAP2A)

Recombinant Human Ras-related protein Rap-2a (RAP2A)

  • 中文名称：
    人RAP2A重组蛋白
  • 货号：
    CSB-YP019326HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAP2A重组蛋白
  • 货号：
    CSB-EP019326HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAP2A重组蛋白
  • 货号：
    CSB-EP019326HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAP2A重组蛋白
  • 货号：
    CSB-BP019326HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAP2A重组蛋白
  • 货号：
    CSB-MP019326HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RAP2A
  • Uniprot No.：
    P10114
  • 别名：
    RAP2A; Ras-related protein Rap-2a; RbBP-30
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-180
  • 氨基酸序列
    MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYEKVP VILVGNKVDL ESEREVSSSE GRALAEEWGC PFMETSAKSK TMVDELFAEI VRQMNYAAQP DKDDPCCSAC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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RAP2A antibodies

靶点详情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
  • 基因功能参考文献：
    1. The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation. PMID: 27493245
    2. Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells. PMID: 28405688
    3. present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis PMID: 25980814
    4. Single nucleotide polymorphism in RAP2A gene is associated with Peripheral Arterial Disease. PMID: 26488411
    5. the role of Rap2a in carcinogenesis PMID: 25248704
    6. The ectopic expression of Rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase MMP2 and MMP9. PMID: 25728512
    7. downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT PMID: 24293123
    8. Rap2A and TNIK control brush border formation by apical recruitment of MST4 and the subsequent phosphorylation of Ezrin PMID: 22797597
    9. Rap2 enhanced MAP4K4-induced activation of JNK PMID: 14966141
    10. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639
    11. RGS14 activity towards heterotrimeric G-proteins, as either a GAP or a guanine nucleotide dissociation inhibitor, was unaffected by Rap binding. PMID: 16246175
    12. Rap2 is involved in androgen-mediated transcriptional and growth responses of human prostate cancer cells. PMID: 17918750
    13. Study presents evidence of fewer spines and reduced signaling in Rap2 transgenic mice, consistent with an inhibitory role for Rap2 at synapses. PMID: 18701680
    14. analyzed residues that allow RasGEF1 proteins to discriminate between Rap1 and Rap2, and identified Phe39 in the switch I region of Rap2 as a specificity residue. PMID: 19645719

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  • 亚细胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    HGNC: 9861

    OMIM: 179540

    KEGG: hsa:5911

    STRING: 9606.ENSP00000245304

    UniGene: Hs.508480

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