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  4. RAP2A Antibody

RAP2A Antibody

说明书
  • 中文名称：
    RAP2A兔多克隆抗体
  • 货号：
    CSB-PA019326GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P10114
  • 基因名：
    RAP2A
  • 别名：
    RAP2A antibody; Ras-related protein Rap-2a antibody; RbBP-30 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RAP2A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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RAP2A Proteins

靶点详情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
  • 基因功能参考文献：
    1. The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation. PMID: 27493245
    2. Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells. PMID: 28405688
    3. present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis PMID: 25980814
    4. Single nucleotide polymorphism in RAP2A gene is associated with Peripheral Arterial Disease. PMID: 26488411
    5. the role of Rap2a in carcinogenesis PMID: 25248704
    6. The ectopic expression of Rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase MMP2 and MMP9. PMID: 25728512
    7. downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT PMID: 24293123
    8. Rap2A and TNIK control brush border formation by apical recruitment of MST4 and the subsequent phosphorylation of Ezrin PMID: 22797597
    9. Rap2 enhanced MAP4K4-induced activation of JNK PMID: 14966141
    10. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639
    11. RGS14 activity towards heterotrimeric G-proteins, as either a GAP or a guanine nucleotide dissociation inhibitor, was unaffected by Rap binding. PMID: 16246175
    12. Rap2 is involved in androgen-mediated transcriptional and growth responses of human prostate cancer cells. PMID: 17918750
    13. Study presents evidence of fewer spines and reduced signaling in Rap2 transgenic mice, consistent with an inhibitory role for Rap2 at synapses. PMID: 18701680
    14. analyzed residues that allow RasGEF1 proteins to discriminate between Rap1 and Rap2, and identified Phe39 in the switch I region of Rap2 as a specificity residue. PMID: 19645719

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  • 亚细胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    HGNC: 9861

    OMIM: 179540

    KEGG: hsa:5911

    STRING: 9606.ENSP00000245304

    UniGene: Hs.508480

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