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  4. Recombinant Human Protein L-Myc (MYCL)

Recombinant Human Protein L-Myc (MYCL)

  • 中文名称：
    人MYCL重组蛋白
  • 货号：
    CSB-YP015274HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MYCL重组蛋白
  • 货号：
    CSB-EP015274HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MYCL重组蛋白
  • 货号：
    CSB-EP015274HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MYCL重组蛋白
  • 货号：
    CSB-BP015274HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MYCL重组蛋白
  • 货号：
    CSB-MP015274HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MYCL
  • Uniprot No.：
    P12524
  • 别名：
    bHLHe38; Class E basic helix-loop-helix protein 38; l myc 1 proto oncogene; L myc 1 proto-oncogene protein; l myc protein; LMYC; Myc related gene from lung cancer; MYCL 1; MYCL; MYCL1; MYCL1_HUMAN; oncogene lmyc; Protein L-Myc-1; v myc avian myelocytomatosis viral oncogene homolog 1 lung carcinoma derived
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-364
  • 氨基酸序列
    MDYDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGLGPG AGDPAPGIGP PEPWPGGCTG DEAESRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAPGAPRG NPPKASAAPD CTPSLEAGNP APAAPCPLGE PKTQACSGSE SPSDSENEEI DVVTVEKRQS LGIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEEASE RGPQEEVLER DAAGEKEDEE DEEIVSPPPV ESEAAQSCHP KPVSSDTEDV TKRKNHNFLE RKRRNDLRSR FLALRDQVPT LASCSKAPKV VILSKALEYL QALVGAEKRM ATEKRQLRCR QQQLQKRIAY LTGY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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MYCL Proteins

靶点详情

  • 基因功能参考文献：
    1. These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer. PMID: 25528583
    2. Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population. PMID: 23349019
    3. The polymorphism of H-ras and L-myc genes is not related to colorectal cancer risk, but there is a synergy between H-ras and L-myc polymorphisms in the development of rectal cancer. PMID: 22490849
    4. MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827. PMID: 21676885
    5. The results demonstrate that MYCL1 rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer. PMID: 20874233
    6. L-myc polymorphism may affect the induction of lung cancer by smoking PMID: 11802801
    7. L-myc proto oncogene RFLP is associated with lung adenocarcinoma PMID: 11836605
    8. Allelic deletions of L-myc in urine from bladder cancer patients PMID: 11956626
    9. MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmoary fibrosis PMID: 12169206
    10. Colorectal tumor patients whose tumors exhibited loss of heterozygosity at MYCL1 at chromosome 1p34 were likely to have a poor prognosis. PMID: 15014029
    11. polymorphisms in the MYCL1 LD region affect lung cancer survival but that the functional element(s) may show population-specific patterns PMID: 17145094
    12. L-myc gene polymorphism may have a role in risk of thyroid cancer PMID: 18566574
    13. The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC. PMID: 18645122
    14. L-Myc may have a role in Merkel cell carcinoma pathogenesis PMID: 19020549

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7555

    OMIM: 164850

    KEGG: hsa:4610

    STRING: 9606.ENSP00000380494

    UniGene: Hs.437922

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